Fe on W(001) from continuous films to nanoparticles: Growth and magnetic domain structure

The evolution of the structural and magnetic properties of Fe films during growth on the W(001) surface have been studied with low energy electron diffraction, real-time low energy electron microscopy, and quasi-real-time, spin-polarized low energy electron microscopy in the absence of a magnetic field (virgin state). Depending on the growth temperature, different growth modes are observed: growth of atomically rough and highly strained (10.4% tensile) pseudomorphic films at room temperature, kinetically limited layer-by-layer growth (quasi–Frank-van der Merwe growth mode) of smooth pseudomorphic films up to 4 monolayers at around 500 K and growth of fully relaxed three-dimensional Fe islands on top of a thermodynamically stable 2-monolayer-thick wetting layer (Stranski-Krastanov growth mode) at and above 700 K. Around 500 K, layered growth is terminated by partial (2 monolayers) dewetting of the metastable Fe film and formation of thin, partially relaxed, elongated islands on a thermodynamically stable 2 monolayer film. Ferromagnetic order is first detected during growth at room temperature at 2.35 monolayer Fe film thickness. The magnetization is in-plane with a thickness-dependent direction, rotating from the substrate ⟨110⟩ directions at 3 monolayers toward the ⟨100⟩ directions at 4 monolayers and back again toward the ⟨110⟩ directions at about 8 monolayers. The in-plane spin reorientation that occurs at room temperature is accompanied by significant changes of the magnetic domain structure. In the Frank-van der Merwe growth regime, large magnetic domains are observed in metastable 3 and 4 monolayer films. The isolated three-dimensional Fe islands that form in the Stranski-Krastanov regime have vortex, quasi-single domain (C state), or single magnetic domain structures, depending on their size and shape. The detailed results that are obtained with high thickness, lateral and azimuthal angular resolution with spin-polarized low energy electron microscopy are compared with earlier laterally averaging and laterally resolving magnetic studies, and discrepancies are explained

An Assessment of Risk of Iodine Deficiency Among Pregnant Women in Sarawak, Malaysia

Previous findings from a state-wide Iodine Deficiency Disorders (IDD) study among pregnant women (PW) in Sarawak indicated that PW are at risk of IDD and further assessment is needed. This paper describes the methodology used in conducting this study for an assessment of risk of iodine deficiency among pregnant women in Sarawak, Malaysia. A total of 30 maternal child health care clinics (MCHCs) were selected using probability proportional to population size (PPS) sampling technique. The PW sample size was calculated based on 95% confidence interval (CI), relative precision of 5%, design effect of 2, anticipated IDD prevalence of 65.0% and non-response rate of 20%. Thus, the total sample size required was 750 (25 respondents per selected MCHC). The WHO Expanded Programme on Immunization (EPI) surveys approach was used to randomly select the first respondent and subsequent respondents were chosen until the required number of PW was met. The required data were obtained through: face-to-face interviews (socio-demographic and food frequency questionnaire), clinical assessments (thyroid size, and hyper/hypothyroidism) and biochemical analysis (urine and blood serum). A total of 677 PW responded in the study with a response rate of 90.2%. Majority of the PW were at second gravida, aged 25-29 years old and of Malay ethnicity. The methodology used in this study was based on International guidelines which may provide state's estimates. All the necessary steps were taken into consideration to ensure valid and reliable findings on current iodine status among PW

SUMOylation inhibits FOXM1 activity and delays mitotic transition

The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but not by SUMO2/3 at multiple sites. We show that FOXM1 SUMOylation is enhanced in MCF-7 breast cancer cells in response to treatment with epirubicin and mitotic inhibitors. Mutation of five consensus conjugation motifs yielded a SUMOylation-deficient mutant FOXM1. Conversely, fusion of the E2 ligase Ubc9 to FOXM1 generated an auto-SUMOylating mutant (FOXM1-Ubc9). Analysis of wild-type FOXM1 and mutants revealed that SUMOylation inhibits FOXM1 activity, promotes translocation to the cytoplasm and enhances APC/Cdh1-mediated ubiquitination and degradation. Further, expression of the SUMOylation-deficient mutant enhanced cell proliferation compared with wild-type FOXM1, whereas the FOXM1-Ubc9 fusion protein resulted in persistent cyclin B1 expression and slowed the time from mitotic entry to exit. In summary, our findings suggest that SUMOylation attenuates FOXM1 activity and causes mitotic delay in cytotoxic drug response

Block Copolymer at Nano-Patterned Surfaces

We present numerical calculations of lamellar phases of block copolymers at patterned surfaces. We model symmetric di-block copolymer films forming lamellar phases and the effect of geometrical and chemical surface patterning on the alignment and orientation of lamellar phases. The calculations are done within self-consistent field theory (SCFT), where the semi-implicit relaxation scheme is used to solve the diffusion equation. Two specific set-ups, motivated by recent experiments, are investigated. In the first, the film is placed on top of a surface imprinted with long chemical stripes. The stripes interact more favorably with one of the two blocks and induce a perpendicular orientation in a large range of system parameters. However, the system is found to be sensitive to its initial conditions, and sometimes gets trapped into a metastable mixed state composed of domains in parallel and perpendicular orientations. In a second set-up, we study the film structure and orientation when it is pressed against a hard grooved mold. The mold surface prefers one of the two components and this set-up is found to be superior for inducing a perfect perpendicular lamellar orientation for a wide range of system parameters

Thoracic arachnoiditis, arachnoid cyst and syrinx formation secondary to myelography with Myodil, 30 years previously

Spinal arachnoiditis can rarely occur following irritation from foreign body substances, including certain oil based contrast agents used for myelography. We describe a patient with thoracic arachnoiditis, arachnoid cyst and syringomyelia, 30 years following a myelogram with Myodil. A 62-year-old female presented with chronic thoraco-lumbar back pain, a spastic paraparesis and sphincter disturbance. She had undergone a myelogram with Myodil, 30 years previously for investigation of back pain. A MRI scan revealed evidence of arachnoiditis, thoracic syringomyelia (T6–T8) and an anteriorly placed, extramedullary, arachnoid cyst at T10–T12, compressing the cord. At surgery, T7–T10 thoracic laminectomies were carried out and syringo- and cysto-subarachnoid shunts were inserted. At 12 months follow-up, the sphincter disturbance, lower limb weakness and mobility problems had almost resolved. Although, the use of oil based contrast agents such as Myodil has been discontinued, the present case illustrates some of the rare sequelae of its use, manifesting decades later. Aggressive surgical intervention produced symptomatic benefit

Organization of Block Copolymers using NanoImprint Lithography: Comparison of Theory and Experiments

We present NanoImprint lithography experiments and modeling of thin films of block copolymers (BCP). The NanoImprint lithography is used to align perpendicularly lamellar phases, over distances much larger than the natural lamellar periodicity. The modeling relies on self-consistent field calculations done in two- and three-dimensions. We get a good agreement with the NanoImprint lithography setups. We find that, at thermodynamical equilibrium, the ordered BCP lamellae are much better aligned than when the films are deposited on uniform planar surfaces

On the statistics of superlocalized states in self-affine disordered potentials

We investigate the statistics of eigenstates in a weak self-affine disordered potential in one dimension, whose Gaussian fluctuations grow with distance with a positive Hurst exponent $H$. Typical eigenstates are superlocalized on samples much larger than a well-defined crossover length, which diverges in the weak-disorder regime. We present a parallel analytical investigation of the statistics of these superlocalized states in the discrete and the continuum formalisms. For the discrete tight-binding model, the effective localization length decays logarithmically with the sample size, and the logarithm of the transmission is marginally self-averaging. For the continuum Schr\"odinger equation, the superlocalization phenomenon has more drastic effects. The effective localization length decays as a power of the sample length, and the logarithm of the transmission is fully non-self-averaging.Comment: 21 pages, 6 figure

Improved Eavesdropping Detection Strategy in Quantum Direct Communication Protocol Based on Four-particle GHZ State

In order to improve the eavesdropping detection efficiency in two-step quantum direct communication protocol, an improved eavesdropping detection strategy using four-particle GHZ state is proposed, in which four-particle GHZ state is used to detect eavesdroppers. During the security analysis, the method of the entropy theory is introduced, and two detection strategies are compared quantitatively by using the constraint between the information which eavesdropper can obtain and the interference introduced. If the eavesdroppers intend to obtain all information, the eavesdropping detection rate of the original two-step quantum direct communication protocol by using EPR pair block as detection particles is 50%; while the proposed strategy's detection rate is 88%. In the end, the security of the proposed protocol is discussed. The analysis results show that the eavesdropping detection strategy presented is more secure.Comment: 14 pages, 3 figures. arXiv admin note: substantial text overlap with arXiv:quant-ph/0308173 by different author