Population of Maputo by gender and age groups in the censuses of 1997 and 2007.

<p>Population of Maputo by gender and age groups in the censuses of 1997 and 2007.</p

Age-standardized incidence rates (per 100,000) during three time periods and the average annual percentage change in age-standardized rates in the period from 1991–2008.

<p>Age-standardized incidence rates (per 100,000) during three time periods and the average annual percentage change in age-standardized rates in the period from 1991–2008.</p

Age-specific incidence rates of male (A) and female (B) cancers in the periods 1991–1996, 1996–2001 and 2003–2008; and trends in age-standardized incidence rates of the four most frequent cancers in males (C) and females (D) from 1991–2008.

<p>Age-specific incidence rates of male (A) and female (B) cancers in the periods 1991–1996, 1996–2001 and 2003–2008; and trends in age-standardized incidence rates of the four most frequent cancers in males (C) and females (D) from 1991–2008.</p

Representative image of the samples obtained from the central nervous system (A), liver (B), bone marrow (C) and lungs/heart and kidney (D) in the minimally invasive autopsy procedure.

<p>Representative image of the samples obtained from the central nervous system (A), liver (B), bone marrow (C) and lungs/heart and kidney (D) in the minimally invasive autopsy procedure.</p

Representative examples of putative causes of death identified with minimally invasive autopsy sampling.

<p>A) Meningoencephalitis (hematoxylin and eosin, 200x); B) <i>Pneumocysttis jiroveci</i> pneumonia (hematoxylin and eosin, 200x); C) <i>Cryptococcus neoformans</i> infecting the lung (PAS metenamine silver stain, 200x); D) Kaposi’s sarcoma involving the lung (hematoxylin and eosin, 100x).</p

Age, sex, HIV status and pathological and microbiological diagnoses obtained in the 30 minimally invasive autopsies (MIA) performed in the pilot study.

<p>M: male; F: female</p><p>* necrosis and hemorrhage in the cerebral parenchyma with negative stains for microorganisms</p><p>^# etiological agent detected in the pathology sample by immunohistochemistry or special stains</p><p>HBV: hepatitis B virus</p><p>HHV-8: human herpes virus 8</p><p>** minimal perivascular inflammatory infiltrate in CNS parenchyma after immunohistochemical analysis against CD45.</p><p>Age, sex, HIV status and pathological and microbiological diagnoses obtained in the 30 minimally invasive autopsies (MIA) performed in the pilot study.</p

Type and main characteristics of the different needles used in the minimally invasive autopsy procedure for each particular biopsy, puncture sites and number of samples to be obtained.

<p>^# Becton Dickinson, FranklinLakes, NJ, USA</p><p>^##KAI Europe GMBH, Solingen, Germany</p><p>* BARD Biopsy Systems, Tempe, AZ; USA</p><p>**Mana-Tech Ltd, Staffordshire, UK</p><p>*** HS Hospital Service S.P.A, Rome, Italy</p><p>The organ tissues are presented in the order in which the samples were collected.</p

Procedures for the collection of cerebrospinal fluid (A), peripheral blood (B), liver (C), lung (D), spleen (E), and the central nervous system biopsy (F) (designed by Xabier Sagasta).

<p>Procedures for the collection of cerebrospinal fluid (A), peripheral blood (B), liver (C), lung (D), spleen (E), and the central nervous system biopsy (F) (designed by Xabier Sagasta).</p

Median area of tissue for histological evaluation obtained from each organ in mm².

<p>Median area of tissue for histological evaluation obtained from each organ in mm².</p

Sensitivity, specificity, and positive and negative predictive values and percentage of false-positive and false-negative diagnoses and cases correctly classified by the minimally invasive autopsy.

<p>Sensitivity, specificity, and positive and negative predictive values and percentage of false-positive and false-negative diagnoses and cases correctly classified by the minimally invasive autopsy.</p