Analyses of EORTC QLQ-C30 Global and functioning scales.

<p>Analyses of EORTC QLQ-C30 Global and functioning scales.</p

Effects of <i>Anma</i> therapy (Japanese massage) on health-related quality of life in gynecologic cancer survivors: A randomized controlled trial

<div><p>Objectives</p><p><i>Anma</i> therapy (Japanese massage therapy, AMT) significantly reduces the severity of physical complaints in survivors of gynecologic cancer. However, whether this reduction of severity is accompanied by improvement in health-related quality of life is unknown.</p><p>Methods</p><p>Forty survivors of gynecologic cancer were randomly allocated to either an AMT group that received one 40-min AMT session per week for 8 weeks or a no-AMT group. We prospectively measured quality of life by using the Japanese version of the European Organization for Research and Treatment of Cancer QLQ-C30 version 3.0 (EORTC QLQ-C30) at baseline and at 8-week follow-up. The QLQ-C30 response rate was 100%. Hospital Anxiety Depression Scale (HADS), Profile of Mood States (POMS), and Measure of Adjustment to Cancer were also prespecified and prospectively evaluated.</p><p>Results</p><p>The QLQ-C30 Global Health Status and Quality of Life showed significant improvement at 8 weeks (<i>P</i> = 0.042) in the AMT group compared with the no-AMT group, and the estimated mean difference reached a minimal clinically important difference of 10 points (10.4 points, 95% CI = 1.2 to 19.6). Scores on fatigue and insomnia showed significant improvement in the AMT group compared with the no-AMT group (<i>P</i> = 0.047 and 0.003, respectively). There were no significant between-group improvements in HADS anxiety and depression scales; however, POMS-assessed anger-hostility showed significant improvement in the AMT group compared with the no-AMT group (<i>p</i> = 0.028).</p><p>Conclusions</p><p>AMT improved health-related quality of life in gynecologic cancer survivors. AMT can be of potential benefit for applications in oncology.</p></div

Analyses of EORTC QLQ-C30 symptom scales.

<p>Analyses of EORTC QLQ-C30 symptom scales.</p

CONSORT flowchart of participant recruitment [11].

<p>AMT: <i>Anma</i> massage therapy.</p

Demographics and baseline characteristics of cancer survivors.

<p>Demographics and baseline characteristics of cancer survivors.</p

Changes in Global Health scores measured by using the EORTC QLQ-C30.

<p>AMT = <i>Anma</i> massage therapy.</p

Analyses of Hospital Anxiety Depression Scale (HADS) scale.

<p>Analyses of Hospital Anxiety Depression Scale (HADS) scale.</p

Additional file 1 of Whole-genome analysis of human papillomavirus 67 isolated from Japanese women with cervical lesions

Additional file 1. Multiple sequence alignment of available HPV67 whole genomes

Additional file 1: of Whole-genome analysis of human papillomavirus genotypes 52 and 58 isolated from Japanese women with cervical intraepithelial neoplasia and invasive cervical cancer

Lineage/sublineage-specific SNPs of HPV52/58. (DOCX 53 kb

Comparison between DNA and RNA of HPV E6/E7 and human β2-microglobulin (B2M) genes.

<p>The size of E6/E7 DNA is 652bp for HeLa and 622bp for CaSki, same as E6 mRNA. The size of B2M DNA is 775bp and B2M RNA is 148bp.</p