Does a loaded warm-up influence jump asymmetry and badminton-specific change of direction performance?

Purpose: Previously, it has been shown that loaded warm-up (LWU) can improve change of direction speed (CODS) in professional badminton players. However, the effect of asymmetry on CODS in badminton players and the influence of LWU on asymmetry has not been examined. Methods: Twenty-one amateur badminton players (age: 29.5 ± 8.4; playing experience: 8.4 ± 4.2 years) completed two trials. In the first, they performed a control warm-up (CWU). In the second, they performed the same warm-up but with three exercises loaded with a weight vest (LWU). Following both warm-ups, players completed single leg jump (SLCMJ) and badminton-specific CODS tests. Results: No significant differences between CWU and LWU were observed for CODS, SLCMJ or SLCMJ asymmetry. However, small effect sizes suggested faster CODS (mean difference: -5%; d = -0.32) and lower asymmetries (mean difference: -3%; d = -0.39) following LWU. Five players (24%) experienced CODS improvements greater than the minimum detectable change whilst two (10%) responded negatively. Asymmetry was not correlated with CODS following CWU (ρ = 0.079; p = 0.733) but was negatively associated with CODS after LWU (ρ = -0.491; p = 0.035). Conclusion: LWU may prove a strategy to trial on an individual basis but generic recommendations should not be applied

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence

Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses. Here, we define the function of the vaccinia virus (VV) protein A46R and show it inhibits intracellular signalling by a range of TLRs. TLR signalling is triggered by homotypic interactions between the Toll-like-interleukin-1 resistance (TIR) domains of the receptors and adaptor molecules. A46R contains a TIR domain and is the only viral TIR domain-containing protein identified to date. We demonstrate that A46R targets the host TIR adaptors myeloid differentiation factor 88 (MyD88), MyD88 adaptor-like, TIR domain-containing adaptor inducing IFN-beta (TRIF), and the TRIF-related adaptor molecule and thereby interferes with downstream activation of mitogen-activated protein kinases and nuclear factor kappaB. TRIF mediates activation of interferon (IFN) regulatory factor 3 (IRF3) and induction of IFN-beta by TLR3 and TLR4 and suppresses VV replication in macrophages. Here, A46R disrupted TRIF-induced IRF3 activation and induction of the TRIF-dependent gene regulated on activation, normal T cell expressed and secreted. Furthermore, we show that A46R is functionally distinct from another described VV TLR inhibitor, A52R. Importantly, VV lacking the A46R gene was attenuated in a murine intranasal model, demonstrating the importance of A46R for VV virulence

A Method for Individual Source Brightness Estimation in Single- and Multi-band Data

We present a method of reliably extracting the flux of individual sources from sky maps in the presence of noise and a source population in which number counts are a steeply falling function of flux. The method is an extension of a standard Bayesian procedure in the millimeter/submillimeter literature. As in the standard method, the prior applied to source flux measurements is derived from an estimate of the source counts as a function of flux, dN/dS. The key feature of the new method is that it enables reliable extraction of properties of individual sources, which previous methods in the literature do not. We first present the method for extracting individual source fluxes from data in a single observing band, then we extend the method to multiple bands, including prior information about the spectral behavior of the source population(s). The multi-band estimation technique is particularly relevant for classifying individual sources into populations according to their spectral behavior. We find that proper treatment of the correlated prior information between observing bands is key to avoiding significant biases in estimations of multi-band fluxes and spectral behavior, biases which lead to significant numbers of misclassified sources. We test the single- and multi-band versions of the method using simulated observations with observing parameters similar to that of the South Pole Telescope data used in Vieira, et al. (2010).Comment: 11 emulateapj pages, 3 figures, revised to match published versio

Radial HI Profiles at the Periphery of Galactic Disks: The Role of Ionizing Background Radiation

Observations of neutral hydrogen in spiral galaxies reveal a sharp cutoff in the radial density profile at some distance from the center. Using 22 galaxies with known HI distributions as an example, we discuss the question of whether this effect can be associated exclusively with external ionizing radiation, as is commonly assumed. We show that before the surface density reaches $\sigma_{\textrm{HI}}\le 0.5 {\cal M}_\odot/{\textrm {pc}}^2$(the same for galaxies of different types), it is hard to expect the gas to be fully ionized by background radiation. For two of 13 galaxies with a sharp drop in the HI profile, the "steepening" can actually be caused by ionization. At the same time, for the remaining galaxies, the observed cutoff in the radial HI profile is closer to the center than if it was a consequence of ionization by background radiation and, therefore, it should be caused by other factors.Comment: 15 pages, 6 figure

Infrared 3-4 Micron Spectroscopic Investigations of a Large Sample of Nearby Ultraluminous Infrared Galaxies

We present infrared L-band (3-4 micron) nuclear spectra of a large sample of nearby ultraluminous infrared galaxies (ULIRGs).ULIRGs classified optically as non-Seyferts (LINERs, HII-regions, and unclassified) are our main targets. Using the 3.3 micron polycyclic aromatic hydrocarbon (PAH) emission and absorption features at 3.1 micron due to ice-covered dust and at 3.4 micron produced by bare carbonaceous dust, we search for signatures of powerful active galactic nuclei (AGNs) deeply buried along virtually all lines-of-sight. The 3.3 micron PAH emission, the signatures of starbursts, is detected in all but two non-Seyfert ULIRGs, but the estimated starburst magnitudes can account for only a small fraction of the infrared luminosities. Three LINER ULIRGs show spectra typical of almost pure buried AGNs, namely, strong absorption features with very small equivalent-width PAH emission. Besides these three sources, 14 LINER and 3 HII ULIRGs' nuclei show strong absorption features whose absolute optical depths suggest an energy source more centrally concentrated than the surrounding dust, such as a buried AGN. In total, 17 out of 27 (63%) LINER and 3 out of 13 (23%) HII ULIRGs' nuclei show some degree of evidence for powerful buried AGNs, suggesting that powerful buried AGNs may be more common in LINER ULIRGs than in HII ULIRGs. The evidence of AGNs is found in non-Seyfert ULIRGs with both warm and cool far-infrared colors. These spectra are compared with those of 15 ULIRGs' nuclei with optical Seyfert signatures taken for comparison.The overall spectral properties suggest that the total amount of dust around buried AGNs in non-Seyfert ULIRGs is systematically larger than that around AGNs in Seyfert 2 ULIRGs.Comment: 56 pages, 9 figures, accepted for publication in ApJ (20 January 2006, vol 637 issue

Mapping Children's Discussions of Evidence in Science to Assess Collaboration and Argumentation

The research reported in this paper concerns the development of children's skills of interpreting and evaluating evidence in science. Previous studies have shown that school teaching often places limited emphasis on the development of these skills, which are necessary for children to engage in scientific debate and decision-making. The research, undertaken in the UK, involved four collaborative decision-making activities to stimulate group discussion, each was carried out with five groups of four children (10-11 years old). The research shows how the children evaluated evidence for possible choices and judged whether their evidence was sufficient to support a particular conclusion or the rejection of alternative conclusions. A mapping technique was developed to analyse the discussions and identify different "levels" of argumentation. The authors conclude that suitable collaborative activities that focus on the discussion of evidence can be developed to exercise children's ability to argue effectively in making decisions

The Central Charge of the Warped AdS^3 Black Hole

The AdS/CFT conjecture offers the possibility of a quantum description for a black hole in terms of a CFT. This has led to the study of general AdS^3 type black holes with a view to constructing an explicit toy quantum black hole model. Such a CFT description would be characterized by its central charge and the dimensions of its primary fields. Recently the expression for the central charges (C_L, C_R) of the CFT dual to the warped AdS^3 have been determined using asymptotic symmetry arguments. The central charges depend, as expected, on the warping factor. We show that topological arguments, used by Witten to constrain central charges for the BTZ black hole, can be generalized to deal with the warped AdS^3 case. Topology constrains the warped factor to be rational numbers while quasinormal modes are conjectured to give the dimensions of primary fields. We find that in the limit when warping is large or when it takes special rational values the system tends to Witten's conjectured unique CFT's with central charges that are multiples of 24.Comment: 6 pages, Latex fil

Non-Singular Solutions for S-branes

Exact, non-singular, time-dependent solutions of Maxwell-Einstein gravity with and without dilatons are constructed by double Wick rotating a variety of static, axisymmetric solutions. This procedure transforms arrays of charged or neutral black holes into s-brane (spacelike brane) solutions, i.e. extended, short-lived spacelike defects. Along the way, new static solutions corresponding to arrays of alternating-charge Reissner-Nordstrom black holes, as well as their dilatonic generalizations, are found. Their double Wick rotation yields s-brane solutions which are periodic in imaginary time and potential large-N duals for the creation/decay of unstable D-branes in string theory.Comment: 21 pages, 3 figure

Chiral Supergravity

We study the linearized approximation of N=1 topologically massive supergravity around AdS3. Linearized gravitino fields are explicitly constructed. For appropriate boundary conditions, the conserved charges demonstrate chiral behavior, so that chiral gravity can be consistently extended to chiral supergravity.Comment: 30 page