A detailed study of the diastereoselective catalytic hydrogenation of 6-hydroxytetrahydroisoquinoline-(3R)-carboxylic ester intermediates

A key step towards a highly-selective antagonist of ionotropic glutamate receptors entails the diastereoselective arene hydrogenation of an enantiopure tetrahydroisoquinoline. An extensive screen using parallel reactors was conducted and led to the discovery of several Pd/C catalysts giving high yield and improved diastereoselectivity from 75 : 25 to 95 : 5. A detailed kinetic study of the best system was performed and supports the reduction occuring in two-steps.

The Acceptability Among Health Researchers and Clinicians of Social Media to Translate Research Evidence to Clinical Practice: Mixed-Methods Survey and Interview Study

Background: Establishing and promoting connections between health researchers and health professional clinicians may help translate research evidence to clinical practice. Social media may have the capacity to enhance these connections. Objective: The aim of this study was to explore health researchers’ and clinicians’ current use of social media and their beliefs and attitudes towards the use of social media for communicating research evidence. Methods: This study used a mixed-methods approach to obtain qualitative and quantitative data. Participation was open to health researchers and clinicians. Data regarding demographic details, current use of social media, and beliefs and attitudes towards the use of social media for professional purposes were obtained through an anonymous Web-based survey. The survey was distributed via email to research centers, educational and clinical institutions, and health professional associations in Australia, India, and Malaysia. Consenting participants were stratified by country and role and selected at random for semistructured telephone interviews to explore themes arising from the survey. Results: A total of 856 participants completed the questionnaire with 125 participants declining to participate, resulting in a response rate of 87.3%. 69 interviews were conducted with participants from Australia, India, and Malaysia. Social media was used for recreation by 89.2% (749/840) of participants and for professional purposes by 80.0% (682/852) of participants. Significant associations were found between frequency of professional social media use and age, gender, country of residence, and graduate status. Over a quarter (26.9%, 229/852) of participants used social media for obtaining research evidence, and 15.0% (128/852) of participants used social media for disseminating research evidence. Most participants (95.9%, 810/845) felt there was a role for social media in disseminating or obtaining research evidence. Over half of the participants (449/842, 53.3%) felt they had a need for training in the use of social media for professional development. A key barrier to the professional use of social media was concerns regarding trustworthiness of information. Conclusions: A large majority of health researchers and clinicians use social media in recreational and professional contexts. Social media is less frequently used for communication of research evidence. Training in the use of social media for professional development and methods to improve the trustworthiness of information obtained via social media may enhance the utility of social media for communicating research evidence. Future studies should investigate the efficacy of social media in translating research evidence to clinical practice

How to Stop (Worrying and Love) the Bubble: Boundary Changing Solutions

We discover that a class of bubbles of nothing are embedded as time dependent scaling limits of previous spacelike-brane solutions. With the right initial conditions, a near-bubble solution can relax its expansion and open the compact circle. Thermodynamics of the new class of solutions is discussed and the relationships between brane/flux transitions, tachyon condensation and imaginary D-branes are outlined. Finally, a related class of simultaneous connected S-branes are also examined.Comment: 47 pages; v2 introduction to Weyl cards added, comments added, references added, typos corrected, matches JHEP versio

Strings from Tachyons

We propose a new interpretation of the c=1 matrix model as the world-line theory of N unstable D-particles, in which the hermitian matrix is provided by the non- abelian open string tachyon. For D-particles in 1+1-d string theory, we find a direct quantitative match between the closed string emission due to a rolling tachyon and that due to a rolling eigenvalue in the matrix model. We explain the origin of the double-scaling limit, and interpret it as an extreme representative of a large equivalence class of dual theories. Finally, we define a concrete decoupling limit of unstable D-particles in IIB string theory that reduces to the c=1 matrix model, suggesting that 1+1-d string theory represents the near-horizon limit of an ultra-dense gas of IIB D-particles.Comment: 30 pages, 4 figures; v2: added references, improved discussion of Liouville boundary states, v3: small correction

Seasonal and diurnal surveillance of treated and untreated wastewater for human enteric viruses

Understanding the abundance and fate of human viral pathogens in wastewater is essential when assessing the public health risks associated with wastewater discharge to the environment. Typically, however, the microbiological monitoring of wastewater is undertaken on an infrequent basis and peak discharge events may be missed leading to the misrepresentation of risk levels. To evaluate diurnal patterns in wastewater viral loading, we undertook 3-day sampling campaigns with bi-hourly sample collection over three seasons at three wastewater treatment plants. Untreated influent was collected at Ganol and secondary-treated effluent was sampled at Llanrwst and Betws-y-Coed (North Wales, UK). Our results confirmed the presence of human adenovirus (AdV), norovirus genotypes I and II (NoVGI and NoVGII) in both influent and effluent samples while sapovirus GI (SaVGI) was only detected in influent water. The AdV titre was high and relatively constant in all samples, whereas the NoVGI, NoVGII and SaVGI showed high concentrations during autumn and winter and low counts during the summer. Diurnal patterns were detected in pH and turbidity for some sampling periods; however, no such changes in viral titres were observed apart from slight fluctuations in the influent samples. Our findings suggest that viral particle number in wastewater is not affected by daily chemical fluctuations. Hence, a grab sample taken at any point during the day may be sufficient to enumerate the viral load of wastewater effluent within an order of magnitude while four samples a day are recommended for testing wastewater influent samples

The LMC eclipsing binary HV 2274: fundamental properties and comparison with evolutionary models

We are carrying out an international, multi-wavelength program to determine the fundamental properties and independent distance estimates of selected eclipsing binaries in the LMC and SMC. Eclipsing binaries with well-defined double-line radial velocity curves and light curves provide valuable information on orbital and physical properties of their component stars. The study of stars in the LMC and SMC where the metal abundances are significantly lower than solar provides an important opportunity to test stellar atmosphere, interior and evolution models, and opacities. For the first time, we can also measure direct M-L relations for stars outside our Galaxy. In this paper we concentrate on the determination of the orbital and physical properties of HV 2274 from analyses of light curves and new radial velocity curves formed from HST/GHRS observations. From UV/optical spectrophotometry of HV 2274 obtained with HST/FOS, the temperatures and the metallicity of the stars were found, as well as the interstellar extinction of the system. The values of mass, absolute radius, and effective temperature, for the primary and secondary stars are: 12.2(7) Mo, 9.9(2) Ro, 23000(180) K, and 11.4(7) Mo, 9.0(2) Ro, 23110(180) K, respectively. The age of the system (17(2) Myr), helium abundance (Y=0.26(3)) and a lower limit of the convective core overshooting parameter of 0.2 were obtained from fitting the stellar data with evolution models. The apsidal motion analysis corroborates that some amount of convective overshooting (0.2-0.5) is needed.Comment: 39 pages, 9 figures, accepted for publication in Ap

Two-dimensional superstrings and the supersymmetric matrix model

We present evidence that the supersymmetric matrix model of Marinari and Parisi represents the world-line theory of N unstable D-particles in type II superstring theory in two dimensions. This identification suggests that the matrix model gives a holographic description of superstrings in a two-dimensional black hole geometry.Comment: 22 pages, 2 figures; v2: corrected eqn 4.6; v3: corrected appendices and discussion of vacua, added ref

Quality of Life and Clinical Outcomes in Elderly Patients Treated with Ventricular Pacing as Compared with Dual-Chamber Pacing

ABSTRACT Background Standard clinical practice permits the use of either single-chamber ventricular pacemakers or dual-chamber pacemakers for most patients who require cardiac pacing. Ventricular pacemakers are less expensive, but dual-chamber pacemakers are believed to be more physiologic. However, it is not known whether either type of pacemaker results in superior clinical outcomes. Methods The Pacemaker Selection in the Elderly study was a 30-month, single-blind, randomized, controlled comparison of ventricular pacing and dualchamber pacing in 407 patients 65 years of age or older in 29 centers. Patients received a dual-chamber pacemaker that had been randomly programmed to either ventricular pacing or dual-chamber pacing. The primary end point was health-related quality of life as measured by the 36-item Medical Outcomes Study Short-Form General Health Survey. Results The average age of the patients was 76 years (range, 65 to 96), and 60 percent were men. Quality of life improved significantly after pacemaker implantation (P0.001), but there were no differences between the two pacing modes in either the quality of life or prespecified clinical outcomes (including cardiovascular events or death). However, 53 patients assigned to ventricular pacing (26 percent) were crossed over to dual-chamber pacing because of symptoms related to the pacemaker syndrome. Patients with sinus-node dysfunction, but not those with atrioventricular block, had moderately better quality of life and cardiovascular functional status with dual-chamber pacing than with ventricular pacing. Trends of borderline statistical significance in clinical end points favoring dual-chamber pacing were observed in patients with sinus-node dysfunction, but not in those with atrioventricular block. Conclusions The implantation of a permanent pacemaker improves health-related quality of life. The quality-of-life benefits associated with dualchamber pacing as compared with ventricular pacing are observed principally in the subgroup of patients with sinus-node dysfunction. (N Engl J Med 1998;338:1097-104.