Melanin and Nicotine: A Review of the Literature

The role of melanin in nicotine uptake and metabolism has received little attention. Because nicotine has been shown to accumulate in tissues containing melanin, exploring links between melanin and nicotine may provide additional clues to understanding smoking behavior and disease effects. To examine the scientific literature on the relationship between melanin and nicotine, we conducted a PubMed search. We also searched online archives of internal tobacco industry documents. We retrieved and reviewed 82 published research papers related to melanin and nicotine or melanin and metabolism of other drugs, and 150 relevant internal tobacco industry documents. The published literature suggests that nicotine may accumulate in human tissues containing melanin and this retention may increase melanin synthesis. Existing research on the relationship between melanin and nicotine lacks an adequate consideration of this relationship’s potential impact, if any, on nicotine metabolism, level of nicotine dependence, and ability to quit smoking. Differential accumulation of nicotine in melanin-containing tissues could have implications for individuals with high levels of melanin

Conveying misinformation: Top-ranked Japanese books on tobacco

<p>Abstract</p> <p>Background</p> <p>Tobacco control efforts in Japan have lagged other high income countries, possibly because the Japanese government partially owns Japan Tobacco, Inc. In Japan, tobacco use is still often regarded as an issue of manners rather than an issue of health. Information about tobacco is available, but may not always be accurate. We explored what information Japanese consumers might access by reading popular Japanese books about tobacco.</p> <p>Methods</p> <p>We searched Amazon.com Japan using the term "Tobacco", identifying the top 12 books by "relevance" and "bestselling." We eliminated duplicates and books not concerned with tobacco use and classified the remaining books as pro-smoking, anti-smoking, or neutral. We reviewed the pro-smoking books, published 2004-2009, and analyzed examples of misinformation by theme.</p> <p>Results</p> <p>Pro-smoking popular books conveyed five types of misinformation: doubt about science; suggestions that smoking increased health, longevity, virility, etc.; trivializing tobacco's effects; attacking public health advocates/authorities; and linking tobacco use with authenticity, history, or civil rights. At least one book was authored by a former Japan Tobacco employee; another used a popular Japan Tobacco advertising phrase.</p> <p>Conclusions</p> <p>Creating doubt and confusion about tobacco serves tobacco industry interests and re-creates a strategy developed by US tobacco interests more than 40 years ago. Japanese readers may be misled by texts such as those reviewed. Tobacco control and public health advocates in Japan and globally should expose and counter such misinformation. "Naming and shaming" may be effective.</p

Tobacco industry issues management organizations: Creating a global corporate network to undermine public health

<p>Abstract</p> <p>Background</p> <p>The global tobacco epidemic claims 5 million lives each year, facilitated by the ability of transnational tobacco companies to delay or thwart meaningful tobacco control worldwide. A series of cross-company tobacco industry "issues management organizations" has played an important role in coordinating and implementing common strategies to defeat tobacco control efforts at international, national, and regional levels. This study examines the development and enumerates the activities of these organizations and explores the implications of continuing industry cooperation for global public health.</p> <p>Methods</p> <p>Using a snowball sampling strategy, we collected documentary data from tobacco industry documents archives and assembled them into a chronologically organized case study.</p> <p>Results</p> <p>The International Committee on Smoking Issues (ICOSI) was formed in 1977 by seven tobacco company chief executives to create common anti-tobacco control strategies and build a global network of regional and national manufacturing associations. The organization's name subsequently changed to INFOTAB. The multinational companies built the organization rapidly: by 1984, it had 69 members operating in 57 countries. INFOTAB material, including position papers and "action kits" helped members challenge local tobacco control measures and maintain tobacco-friendly environments. In 1992 INFOTAB was replaced by two smaller organizations. The Tobacco Documentation Centre, which continues to operate, distributes smoking-related information and industry argumentation to members, some produced by cross-company committees. Agro-Tobacco Services, and now Hallmark Marketing Services, assists the INFOTAB-backed and industry supported International Tobacco Growers Association in advancing claims regarding the economic importance of tobacco in developing nations.</p> <p>Conclusion</p> <p>The massive scale and scope of this industry effort illustrate how corporate interests, when threatened by the globalization of public health, sidestep competitive concerns to coordinate their activities. The global network of national and regional manufacturing associations created and nurtured by INFOTAB remains active, particularly in relation to the recently negotiated global health treaty, the Framework Convention on Tobacco Control. Policymakers should be aware that although these associations claim to represent only national or regional interests, they are allied to and coordinated with a confederation of transnational tobacco companies seeking to protect profits by undermining public health.</p

Discussion forum rubrics: Using rubrics to enhance and increase project management students' participation in online discussions

This paper examines the impact of using a discussion forum grading rubric to encourage and enhance discussions (posts) in an online introduction to project management course.&nbsp;The study consists of 53 Master of Business Administration (MBA) students enrolled in three sections of the course from October 2010 to May 2011. A control group of 20 students was compared to two experimental groups of 16 and 17 students respectively. The two experimental groups were given the specific grading rubric and instructions designed to encourage online conversation; the control group was not.&nbsp;The results indicate that there was a statistical difference in average postings per student between the two experimental groups and the control group but no statistical difference between the two experimental groups. The results suggest that the use of a rubric specifically designed to engage the student and expand the student's learning experience can increase online classroom participation and, as a consequence, enhance the educational experience for the online project management student and strengthen the university's MBA program

Assessment of the Provision and Use of Emergency Assistance, Family Homeless Prevention and Assistance Program, and Shelter in Hennepin County

Capstone paper for the fulfillment of the Master of Public Policy degree.Over 1,400 families experience homelessness every night in Hennepin County, and thousands more are at serious risk of entering shelter (Hennepin County Office to End Homelessness, 2017). In order to more effectively target services, county officials would like to understand the demographic characteristics and service use patterns of families at risk of entering shelter. This project aims to provide Hennepin County with more information about who is accessing its services and when they are accessing them; specifically addressing these questions: ● How do families who receive Emergency Assistance (EA), Family Homeless Prevention and Assistance Program (FHPAP), or enter shelter compare across demographics and service use? ● Of those who received EA, FHPAP, or shelter services, how many also received services (i.e., EA, FHPAP) before and when? ● To what extent do families that come to the county for homelessness prevention or homelessness assistance follow Hennepin County’s expected pathway of services: emergency assistance, community prevention (FHPAP), and shelter? ● Of those who received prevention (i.e., EA, FHPAP), how many also entered shelter within one year? Does Hennepin County target its services (i.e., EA, FHPAP) to those most at risk of entering shelter? Our research team conducted quantitative analysis on household heads who received homelessness prevention and assistance services from the County. Data on household heads included demographics and use of other county-administered government services. Samples were constructed to look backwards and forwards from families’ interactions with homelessness prevention and assistance services to understand the use and effectiveness of these services. Our research found the majority of families accessing preventive services had a female head of household between the ages of 25 to 34 with one to two children. Relative to their populations in Hennepin County, African American families were disproportionately represented in use of preventative services and shelter. American Indian families were disproportionately represented in shelter and underserved by EA and FHPAP

Linking the Pinware, Baraboo, and Picuris Orogens: Recognition of a Trans-Laurentian ca. 1520–1340 Ma Orogenic Belt

It is proposed that the Pinware orogen of eastern Canada, the Baraboo orogen of the midcontinent, and the Picuris orogen of the southwestern United States delineate a previously unrecognized, ~5000-km-long, ca. 1520–1340 Ma trans-Laurentian orogenic belt. All three orogenic provinces are characterized by Mesoproterozoic sedimentation, magmatism, metamorphism, and deformation—the hallmarks of a tectonically active plate margin. Tectonism was diachronous, with the earliest stages beginning ca. 1520 Ma in eastern Canada and ca. 1500 Ma in the southwest United States. Magmatic zircon age distributions are dominated by Mesoproterozoic, unimodal to multimodal age peaks between ca. 1500 and 1340 Ma. The onset of magmatism in the Pinware and Baraboo orogens was ca. 1520 Ma, and onset for the Picuris orogen was ca. 1485 Ma. Detrital zircon age distributions within each orogenic province yield maximum depositional ages between ca. 1570 and 1450 Ma. Minimum depositional ages generally fall between ca. 1500 and 1435 Ma, as constrained by crosscutting intrusions, metatuff layers, or the age of subsequent metamorphism. Metamorphic mineral growth ages from zircon, garnet, and monazite yield peak ages between ca. 1500 and 1350 Ma and tend to be older in the Pinware and Baraboo orogens than in the Picuris orogen. The 40Ar/39Ar cooling ages for hornblende, muscovite, and biotite yield significant peak ages between ca. 1500 and 1350 Ma in the Baraboo and Picuris orogens. We propose that the Pinware-Baraboo-Picuris orogen formed in a complex, diachronous, convergent margin setting along the southern edge of Laurentia from ca. 1520 to 1340 Ma

Accelerated degradation testing impacts the degradation processes in 3D printed amorphous PLLA

Additive manufacturing and electrospinning are widely used to create degradable biomedical components. This work presents important new data showing that the temperature used in accelerated tests has a significant impact on the degradation process in amorphous 3D printed poly-l-lactic acid (PLLA) fibres. Samples (c. 100 μm diameter) were degraded in a fluid environment at 37°C, 50°C and 80 °C over a period of 6 months. Our findings suggest that across all three fluid temperatures, the fibres underwent bulk homogeneous degradation. A three-stage degradation process was identified by measuring changes in fluid pH, PLLA fibre mass, molecular weight and polydispersity index. At 37 °C, the fibres remained amorphous but, at elevated temperatures, the PLLA crystallised. A short-term hydration study revealed a reduction in glass transition (Tg), allowing the fibres to crystallise, even at temperatures below the dry Tg. The findings suggest that degradation testing of amorphous PLLA fibres at elevated temperatures changes the degradation pathway which, in turn, affects the sample crystallinity and microstructure. The implication is that, although higher temperatures might be suitable for testing bulk material, predictive testing of the degradation of amorphous PLLA fibres (such as those produced via 3D printing or electrospinning) should be conducted at 37 °C