VertAlign [posture correction device]

Chronic back pain is a significant problem endemic to today’s society. Without proper attention, improper postures develop when using computers and phones, and, when sustained, can result in permanent damage to the neck and back. VertAlign is a posture correction device which aims to promote healthy posture in individuals such as office workers. The user simply activates the device and wears it around their neck. VertAlign acquires real-time positional data using multiple gyroscope sensors and performs analyses to determine whether the user is sitting in correct or incorrect posture. If incorrect posture is sustained past a user-defined time threshold, a notification is issued to the user in the form of gentle vibration

Blood pressure, executive function, and network connectivity in middle-aged adults at risk of dementia in late life

Midlife blood pressure is associated with structural brain changes, cognitive decline, and dementia in late life. However, the relationship between early adulthood blood pressure exposure, brain structure and function, and cognitive performance in midlife is not known. A better understanding of these relationships in the preclinical stage may advance our mechanistic understanding of vascular contributions to late-life cognitive decline and dementia and may provide early therapeutic targets. To identify resting-state functional connectivity of executive control networks (ECNs), a group independent components analysis was performed of functional MRI scans of 600 individuals from the Coronary Artery Risk Development in Young Adults longitudinal cohort study, with cumulative systolic blood pressure (cSBP) measured at nine visits over the preceding 30 y. Dual regression analysis investigated performance-related connectivity of ECNs in 578 individuals (mean age 55.5 ± 3.6 y, 323 female, 243 Black) with data from the Stroop color-word task of executive function. Greater connectivity of a left ECN to the bilateral anterior gyrus rectus, right posterior orbitofrontal cortex, and nucleus accumbens was associated with better executive control performance on the Stroop. Mediation analyses showed that while the relationship between cSBP and Stroop performance was mediated by white matter hyperintensities (WMH), resting-state connectivity of the ECN mediated the relationship between WMH and executive function. Increased connectivity of the left ECN to regions involved in reward processing appears to compensate for the deleterious effects of WMH on executive function in individuals across the burden of cumulative systolic blood pressure exposure in midlife