Maternal and embryonic p110β kinase activity regulate preimplantation embryogenesis.

<p><b>A</b>) Females of the indicated genotype were crossed with WT males (n = 5 females crossed with 2 different males). The percentage of ovulations which became implanted embryos (left panel) was calculated as follows: [numbers of implanted E13.5 embryos + number of resorptions]/corpus luteum numbers in the ovaries (indicative of the number of ovulated oocytes)] x 100 (right panel). Mann-Whitney: *, p<0.05. <b>B</b>) Females of the indicated genotype were superovulated and mated with a p110β^{<b>D931A/WT</b>} male. Two-cell embryos were recovered from the oviducts and cultured <i>in vitro</i> for 4 days, at which time embryos were scored for development to the morula/blastocyst stage or any earlier developmental stage, and genotyped. Mann-Whitney: *, p<0.05.</p

p110β kinase activity positively regulates female and male fertility.

<p><b>A</b>) Weight of organs in 12-week-old mice (n = 4). <b>B</b>) Mice with the indicated genotype were bred for a 6-month period (cages of 2 females with 1 male; > 3 couples) and the average number of litters per month was assessed. Mann-Whitney: **, p<0.01. <b>C</b>) Average size of litters obtained from breeding pairs (2 females with one male for ≥4 months). Unpaired t-test: *, p<0.05; **, p<0.01.</p