Frequency Of Raised Mean Platelet Volume In Patients With Acute Coronary Syndrome In HIT Hospital Taxila

To determine the frequency of raised Mean Platelet Volume (MPV) in patients with acute coronary syndrome (ACS) in HIT Hospital Taxila. Materials and Methods: A case-control study was at HIT Hospital Taxila. All the patients presented with chest pain who fulfilled the inclusion criteria were recruited into the study. Patients with acute coronary syndrome were included in the case group (ACS group). The patients included in the control group (non-ACS group) had chest pain without having ischemic heart disease or risk of ischemic heart disease. Data were analyzed using SPSS version 28. To find out the correlation between the type of chest pain and mean platelet volume chi-square test was applied. Results: Total 93 patients were included in this study. 51 patients were included in the ACS group while 42 were in non- ACS group. To find out the correlation between the type of chest pain and mean platelet volume chi-square test was applied. The results show a significant association between raised MPV and acute coronary syndrome. Conclusion: Patients with raised MPV are at higher risk of acute coronary disease and complications related to it. It could be used as a predictor of ischemic heart disease and its complications

Dietary habits and physical activity patterns in relation to nutritional status among school-aged children in Pakistan: A cross-sectional study

Background: Childhood malnutrition remains a significant public health problem impacting the physical and mental growth if school aged children, particularly in limited-resource countries. Objective: The study objective was to assess levels of physical activity, patterns of screen time (S.T.), the relationship between physical activity and screen time patterns, and how these factors affect growth status (adjusting for socioeconomic status). Methodology: A cross-sectional study included 3,834 children between 6–14 years attending pre-selected schools. Teachers, students, and parents were invited to fill out a standardized questionnaire, and Body Mass Index (BMI) was calculated using Center for disease control (CDC) centile charts. A Chi-square was performed to see the possible association between any height and weight abnormalities and all possible risk factors. Multivariate logistic regression was applied to see the effect of variables significantly associated with univariate analysis. Results: Approximately 2,447 (63.8%) children were between 11–14 years old and 1,387 (36.2%) were between 4–10 years old. The mean height was 143.71 ± 16.51 centimetres, the mean weight was 36.5 ± 12.9 kilogram, and the mean BMI was 17.16 ± 3.52. Multivariate logistic regression status and junk food combined affected stunting socioeconomic status was significantly associated with being underweight p = 0.001. Conclusion: Childhood obesity and stunting remain significant problems in Pakistani school-going children. These are significantly associated with poverty, a lack of physical activity opportunities, and available food quality

Frequency and impact of slow flow / no flow in primary percutaneous coronary intervention

Objectives: To determine the frequency of slow/no flow in primary percutaneous coronary intervention, to know the clinical and angiographical predictors of the phenomenon, and to investigate the immediate impact of slow/no flow on hemodynamics. Method: The cross-sectional study was conducted at the National Institute of Cardiovascular Diseases, Karachi, from June 2018 to July 2019, and comprised patients presenting with ST elevation myocardial infarction who underwent primary percutaneous coronary intervention. Demographic and clinical details of the patients were recorded. The antegrade flow was assessed and determined using the thrombolysis in myocardial infarction criterion. Patients were assessed for the occurrence, predictors and impact of slow/no flow. Data was analysed using SPSS 21. Results: Of the 559 patients, 441(78.9%) were males. The overall mean age of the sample was 55.86±11.07 years. Angiographical slow/no flow during the procedure occurred in 53 (9.5%) patients, while normal flow was achieved in 506(90.5%). The thrombolysis in myocardial infarction grade in the affected patients was 0 in 10(1.8%), 1 in 15(2.7%), and 2 in 28(5%) patients. Smoking status, Continuous..

Effectiveness of topical application of 15℅ salicyclic acid and 0.1℅ diphencyprone combined in an ointment form for treatment of plantar warts

Objective: To determine the Effectiveness of topical application of 15℅ salicyclic acid and 0.1℅ Diphencyprone combined in an ointment form for treatment of plantar warts. Place and Duration: This Descriptive, case series was held in Dermatology outpatient department, Abbasi Shaheed Hospital Karachi. Method: A sample size of 80 patients with plantar warts were included as calculated by exact 95% confidence interval. Results: Total 80 patients of plantar warts were enrolled. 40 (50%) were females and 40 (50%) were males, with mean age of 31 yrs. 65 patients (81.25%) showed positive response to treatment with combined DPCP and salicyclic acid, while remaining 15 (18.75%) had some mild adverse reactions. Conclusion: As Plantar wart is a common problem in all populations therefore more randomized trials should be done on combined chemical treatments for better outcomes

Anti-Ulcerogenic Evaluation of Torilis Leptophylla Plant Extract on Indomethacin Induced Mice Gastric Ulcer

Introduction: Despite conventional anti-ulcer therapies for peptic ulcer diseases, medicinal plants might provide effective new anti-ulcer compounds or, alternatively, as adjuncts to existing therapies. Aims & Objectives: To evaluate the effects of Torilis leptophylla on indomethacin-induced gastric ulcer in mice. Place and duration of study: It was an experimental study carried out in the Department of Pharmacology, University of Health Sciences, Lahore, from March to December 2016. Material & Methods: Thirty six (36) adult healthy male BALB/C mice were divided equally in 6 groups and assigned as group I (control), group II (positive control), group III–V (TLM low, medium and high dose) and group VI (omeprazole). Gastric ulcers were induced by oral ingestion of indomethacin in groups II -VI. Acute oral toxicity of the plant was also tested. Antiulcer effect was assessed by measuring body weight, amount and pH of gastric juice, ulcer count, severity of gastric lesion, ulcer index, percentage (%) inhibition of ulcer and histopathology of gastric tissue. Results were analyzed by SPSS 20.0, P-value<0.05 was considered significant. Results: Gastric ulcer reduced the body weight in indomethacin induced animals (28 ± 2.53, 29.66 ± 3.88, 29.66 ± 2.33, 31 ± 3.52,32 ± 3.099 g in group II, III, IV, V and VI respectively) at day 3. Omeprazole and TLM treated groups reduced the gastric volume and pH as compared to positive control. Ulcer index (18.83, 5.14, 3.42, 1.71, 1.76 of the group II, III, IV, V and VI respectively) depicted significant reduction by treatment groups. Ulcer's percentage inhibition (72.7, 81.8, 90.88, 90.65 of low, median and high dose of TLM and standard drug respectively) was increased. Histopathological observations were remarkably reversed by TLM treated groups. Conclusion: Torilis leptophylla could significantly protect gastric mucosa from damage by indomethacin

Smart neuropathy detection using machine intelligence: Filling the void between clinical practice and early diagnosis

An important aspect of Smart healthcare involves the development of innovative non-intrusive procedures for early detection and diagnosis of specific illnesses. Essentially, diseases for which very complicated and invasive clinical and pathological tests are required could benefit from such innovations. Neuropathy or nerve loss is a characteristic of several commonly occurring long-term or terminal illnesses such as Diabetes, Multiple Sclerosis, Parkinson's disease, and Alzheimer. The detection of a degree of neuropathy is usually done through biopsy-type procedures in which tissue samples are collected from the body for further tests and visualization. In this paper, an innovative approach is presented by using one of the neuronal-representative organ in the body, the eye, to detect nerve loss. Specifically, small nerves are affected in the eye as the disease progresses. While this is currently a clinical practice in neurology and ophthalmology, it is still highly subjective and depends upon the clinician's perspective and experiences. The presented technique in this paper, attempts to make this procedure highly objective through translating human knowledge of neuropathy grading into a data-centric classification system using the corneal images through Confocal microscope. Clinicians use this common, non-invasive procedure for detecting a variety of anomalies in the eye. However, using the nerve-level resolution of the microscope, the corneal nerve canvas can be visualized and accordingly segmented and classified for possible neuropathy grading, which in turn, give the insight into the disease progression. The technique used in this paper is Adaptive Neuro Fuzzy Inference System (ANFIS) that translates the human understanding of the underlying pathology into numerical decisions that can be utilized as a tool into predicting and early diagnosis of the disease. - 2019 IEEE.This paper was made possible by National Priorities Research Program (NPRP) grant No. 7-234-2-109 from the Qatar National Research Fund (a member of Qatar Foundation). The statements made herein are solely the responsibility of the authors.Scopu

Synthesis and Characterization of Ni-P-Ti Nanocomposite Coatings on HSLA Steel

Nickel Phosphorus (Ni-P) coatings possess tailored mechanical, and anticorrosion properties and have found applications in industries like automotive, oil and gas, electronics, and aerospace. Their properties can further be enhanced by incorporating nanoparticles into their (Ni-P) matrix. In the present study, Ni-P-Ti nanocomposite coatings have been developed on high strength low alloy steel (HSLA) through electroless deposition technique. For this purpose, various concentrations of titanium (Ti) nanoparticles are used in the deposition bath containing 0.0g/L, 0.25g/L, 0.5g/L, 0.75g/L, and 1.0g/L nanoparticles. XDR, SEM, microhardness, and nanoindentation have been carried out to elucidate the role of Ti nanoparticle concertation on the microstructure and mechanical properties of the Ni-P-Ti composite coatings. XRD and EDX results confirm the incorporation of nanoparticles into the Ni-P matrix during deposition processing. SEM and AFM results exhibit the formation of a dense, uniform coating without any observable defects. An increase in the mechanical properties of the Ni-P matrix was observed by the addition of Ti nanoparticles. Superior mechanical properties were shown by the samples containing 0.5g/L Ti nanoparticle concentration. Improvement in the structural, as well as mechanical properties of Ni-P matrix by the addition of Ti, confirms the suitability of Ni-P-Ti composite coatings for various engineering applications

Recurrent bladder leiomyoma: a case report

Abstract Background Bladder leiomyomas are rare benign growths in the bladder, comprising less than 0.5% of bladder tumors with only 250 cases reported globally. They are more common in women. This case involves a 70-year-old woman with recurrent leiomyoma, presenting with lower urinary tract symptoms and painless hematuria. A recurrent bladder leiomyoma is rarely reported, making its presence exceptionally rare. Case presentation A 70-year-old Pakistani woman with hypertension and diabetes presented with lower urinary tract symptoms (LUTS) and painless hematuria. She had a history of similar symptoms in 2010, leading to a diagnosis of bladder leiomyoma via cystoscopy and biopsy. Imaging studies revealed a substantial 3.7 × 4 × 4.0 cm isodense mass with calcifications at the bladder base, along with bladder wall thickening and diverticula. Pathological examination during Transurethral Resection of Bladder Tumor (TURBT) confirmed the presence of bladder tissue with smooth muscle, ruling out malignancy. Immunohistochemical studies supported the diagnosis. A successful TURBT was performed, and the patient recovered well. Discussion Recurrent bladder leiomyoma is a rarely-discussed topic in medical literature. This article primarily aims to review existing studies and present a detailed case study, shedding light on this rare phenomenon