Reward modulates spatial neglect

Copyright @ 2012 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and 85 reproduction in any medium, provided the original author and source are credited. The article was made available through the Brunel University Open Access Publishing Fund.BACKGROUND: Reward has been shown to affect attention in healthy individuals, but there have been no studies addressing whether reward influences attentional impairments in patients with focal brain damage. METHODS: Using two novel variants of a widely-used clinical cancellation task, we assessed whether reward modulated impaired attention in 10 individuals with left neglect secondary to right hemisphere stroke. RESULTS: Reward exposure significantly reduced neglect, as measured by total targets found, left-sided targets found and centre of cancellation, across the patient group. Lesion analysis showed that lack of response to reward was associated with damage to the ipsilateral striatum. CONCLUSIONS: This is the first experimental evidence that reward can modulate attentional impairments following brain damage. These results have significant implications for the development of behavioural and pharmacological therapies for patients with attentional disorders.PM is supported by a HEFCE Clinical Senior Lectureship Award and this research was funded by grants from the UK Academy of Medical Sciences/Wellcome Trust and the NIHR Biomedical Research Centre at Imperial College London. DS is supported by a grant from the UK Medical Research Council (89631). CR is supported by a Brunel Research Initiative Award (BRIEF) and a scientific bursary from the Bial foundation, Portugal

The Scattered Disk as the source of the Jupiter Family comets

The short period Jupiter family comets (JFCs) are thought to originate in the Kuiper Belt; specifically, a dynamical subclass of the Kuiper Belt known as the `scattered disk' is argued to be the dominant source of JFCs. However, the best estimates from observational surveys indicate that this source may fall short by more than two orders of magnitude the estimates obtained from theoretical models of the dynamical evolution of Kuiper belt objects into JFCs. We re-examine the scattered disk as a source of the JFCs and make a rigorous estimate of the discrepancy. We find that the uncertainties in the dynamical models combined with a change in the size distribution function of the scattered disk at faint magnitudes (small sizes) beyond the current observational limit offer a possible but problematic resolution to the discrepancy. We discuss several other possibilities: that the present population of JFCs is a large fluctuation above their long term average, that larger scattered disk objects tidally break-up into multiple fragments during close planetary encounters as their orbits evolve from the trans-Neptune zone to near Jupiter, or that there are alternative source populations that contribute significantly to the JFCs. Well-characterized observational investigations of the Centaurs, objects that are transitioning between the trans-Neptune Kuiper belt region and the inner solar system, can test the predictions of the non-steady state and the tidal break-up hypotheses. The classical and resonant classes of the Kuiper belt are worth re-consideration as significant additional or alternate sources of the JFCs.Comment: 33 pages, 6 figures. Revised Content. To be published in The Astrophysical Journa

Temporoparietal encoding of space and time during vestibular-guided orientation

When we walk in our environment, we readily determine our travelled distance and location using visual cues. In the dark, estimating travelled distance uses a combination of somatosensory and vestibular (i.e., inertial) cues. The observed inability of patients with complete peripheral vestibular failure to update their angular travelled distance during active or passive turns in the dark implies a privileged role for vestibular cues during human angular orientation. As vestibular signals only provide inertial cues of self-motion (e.g., velocity, °/s), the brain must convert motion information to distance information (a process called 'path integration') to maintain our spatial orientation during self-motion in the dark. It is unknown, however, what brain areas are involved in converting vestibular-motion signals to those that enable such vestibular-spatial orientation. Hence, using voxel-based lesion-symptom mapping techniques, we explored the effect of acute right hemisphere lesions in 18 patients on perceived angular position, velocity and motion duration during whole-body angular rotations in the dark. First, compared to healthy controls' spatial orientation performance, we found that of the 18 acute stroke patients tested, only the four patients with damage to the temporoparietal junction showed impaired spatial orientation performance for leftward (contralesional) compared to rightward (ipsilesional) rotations. Second, only patients with temporoparietal junction damage showed a congruent underestimation in both their travelled distance (perceived as shorter) and motion duration (perceived as briefer) for leftward compared to rightward rotations. All 18 lesion patients tested showed normal self-motion perception. These data suggest that the cerebral cortical regions mediating vestibular-motion ('am I moving?') and vestibular-spatial perception ('where am I?') are distinct. Furthermore, the congruent contralesional deficit in time (motion duration) and position perception, seen only in temporoparietal junction patients, may reflect a common neural substrate in the temporoparietal junction that mediates the encoding of motion duration and travelled distance during vestibular-guided navigation. Alternatively, the deficits in timing and spatial orientation with temporoparietal junction lesions could be functionally linked, implying that the temporoparietal junction may act as a cortical temporal integrator, combining estimates of self-motion velocity over time to derive an estimate of travelled distance. This intriguing possibility predicts that timing abnormalities could lead to spatial disorientation

Redshifts of the Gravitational Lenses MG0414+0534 and MG0751+2716

We report redshifts in two gravitational lens systems, MG0414+0534 and MG0751+2716. The lens galaxy in MG0414+0534 lies at z_l=0.9584+/-0.0002. The luminosity and extreme red color of the lens are then typical of a passively evolving, early-type, ~2L* galaxy. The galaxy cannot have a significant global mean extinction without being anomalously luminous. The lens galaxy in MG0751+2716 has a redshift of z_l=0.3502+/-0.0003 and it is a member of a small group. The group includes the nearby, bright companion galaxy whose redshift we confirmed to be z=0.3501+/-0.0001 and a nearby emission line galaxy with z=0.3505+/-0.0003. A second emission line galaxy with z=0.5216+/-0.0001 was found nearly superposed on the first emission line galaxy. The source in MG0751+2716 is a z_s=3.200+/-0.001 radio quasar. For flat universes with Omega_0=1.0 (0.3), 96% (87%) of lenses like MG0414+0534 and 7% (3%) of lenses like MG0751+2716 are expected to have lower lens redshifts than observed.Comment: 9 pages, AASTeX Latex, including 5 Postscript figures, submitted to Astronomical Journa

Does Size Matter in the Airline Industry?

Over the last decade, the U.S. airline industry has transformed itself through mergers, restructurings, bankruptcies, and dissolutions. Also during this time, the airline industry focused on a business model that was driven by an emphasis on asset utilization. This was driven by increasing the load factor to increase cost efficiencies through economies of scale so that the return on invested capital could be improved by reducing the operating costs. This study evaluates economies of scale and resultant cost efficiencies in the U.S. passenger airline industry for the period 2013 to 2018. The research finds that the airline industry is experiencing cost efficiencies with every increase in the size of the airline, but cost efficiencies are not evenly distributed. The paper also finds that the main source of cost efficiency appears to be aircraft maintenance expenses

Search for L5 Earth Trojans with DECam

Most of the major planets in the Solar system support populations of co-orbiting bodies, known as Trojans, at their L4 and L5 Lagrange points. In contrast, Earth has only one known co-orbiting companion. This paper presents the results from a search for Earth Trojans (ETs) using the DECam instrument on the Blanco Telescope at CTIO. This search found no additional Trojans in spite of greater coverage compared to previous surveys of the L5 point. Therefore, the main result of this work is to place the most stringent constraints to date on the population of ETs. These constraints depend on assumptions regarding the underlying population properties, especially the slope of the magnitude distribution (which in turn depends on the size and albedo distributions of the objects). For standard assumptions, we calculate upper limits to a 90 per cent confidence limit on the L5 population of N_(ET) < 1 for magnitude H < 15.5, N_(ET) = 60–85 for H < 19.7, and N_(ET) = 97 for H = 20.4. This latter magnitude limit corresponds to Trojans ∼300 m in size for albedo 0.15. At H = 19.7, these upper limits are consistent with previous L4 ET constraints and significantly improve L5 constraints

More Effective Web Search Using Bigrams and Trigrams

This paper investigates the effectiveness of quoted bigrams and trigrams as query terms to target web search. Prior research in this area has largely focused on static corpora each containing only a few million documents, and has reported mixed (usually negative) results. We investigate the bigram/trigram extraction problem and present an extraction algorithm that shows promising results when applied to real-time web search. We also present a prototype augmented search software package that can leverage the results provided by a web search engine to assist the web searcher identify important phrases and related documents quickly. This software has received favourable feedback in a recent user survey