A dual approach to the linear analysis of elastic structure

Imperial Users onl

A critical appraisal of the design, construction and influence of the Unité d'Habitation, Marseilles, France

The Unité d'Habitation is a seventeen-storey apartment block built between 1947 and 1952 in Marseilles, France. Today the construction of such a building, in almost any part of the world, would hardly be newsworthy; however the construction of the Unité d'Habitation not only attracted global interest at the time, but it can also be seen as one of the most influential buildings of the twentieth century. This was for a number of reasons. The architect was Charles-Edouard Jeanneret-Gris who, better known as Le Corbusier for most of his adult life, was probably the most influential architect of the twentieth century. The building, in many ways, initiated the hegemony of Modern Movement architecture throughout the world. But, perhaps most importantly, it was seen by much of the architectural profession as a prototype for how people should be housed in the future – with consequential major social, environmental and urban impacts. This paper examines the background of the design and describes the construction in detail. It also comments critically on the building's suitability as a model for mass housing, revealing the extent of its various functional failings that have not, as far as the author is aware, previously been exposed

A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease.

Funder: Allergan Incorporated (now AbbVie)INTRODUCTION: This study examined the safety and pharmacodynamic effects of selective muscarinic M1 receptor orthosteric agonist HTL0018318 in 60 patients with mild-to-moderate Alzheimer's disease (AD) on background donepezil 10 mg/day. METHODS: A randomized, double-blind, placebo-controlled 4-week safety study of HTL0018318 with up-titration and maintenance phases, observing exploratory effects on electrophysiological biomarkers and cognition. RESULTS: Treatment-emergent adverse events (TEAEs) were mild and less frequently reported during maintenance versus titration. Headache was most commonly reported (7-21%); 0 to 13% reported cholinergic TEAEs (abdominal pain, diarrhea, fatigue, nausea) and two patients discontinued due to TEAEs. At 1 to 2 hours post-dose, HTL0018318-related mean maximum elevations in systolic and diastolic blood pressure of 5 to 10 mmHg above placebo were observed during up-titration but not maintenance. Postive effects of HTL0018318 were found on specific attention and memory endpoints. DISCUSSION: HTL0018318 was well tolerated in mild-to-moderate AD patients and showed positive effects on attention and episodic memory on top of therapeutic doses of donepezil

Building structures : understanding the basics / third edition

x, 567 p.: ill. ; 25 c