The distribution of HBV integration sites, mutational status of selected tumor suppressor genes and numbers of chromosomal aberrations identified in the 25 patients whose samples were assayed using aCGH assay.

<p> <b>W/O = without mutation; Low aberration number = less than 100 chromosomal aberrations; High aberration number = more than 100 chromosomal aberrations.</b></p

Precise locations of HBV integration events mapped to the FN1 gene.

<p>The chromosome locations were mapped using the UCSC database. The orientation of the cellular gene was compared with that of the integrated HBV genome: same = same direction while opposite = opposite direction.</p

The distribution of break-points in the HBV genome in integrated viral sequences detected using different viral primers.

<p>A and B, HBV genome break-points were obtained using HBV specific primers (S1 and pUTP) lying downstream of the HBx region. C and D, HBV genome break-points were obtained using a primer (HBV1920R) lying downstream of the HBV core region. Solid and Hollow dots represent virus-cell junction sites from tumor derived and non-tumor derived samples respectively. Five of the break-points identified fell outside of the region of the viral genome shown in detail in this figure (at nt 415; nt 2784; nt 1292; nt 546; and nt 3075).</p

Examples of rearrangements of the HBV genome found in integrated viral genomes.

<p>Del = deletion, Ins = insertion.</p