Genome-Guided Transcriptomics, DNA-Protein Interactions, and Variant Calling

Nowadays, molecular biology has definitely become an interdisciplinary science. Toward the study of the functions and the interactions of the biological molecules, such as nucleic acids and proteins, computer science and engineering, along with chemistry and statistics, are routinely engaged. In molecular biology, techniques and methods are constantly developed, and new techniques emerge. Next-generation sequencing and bioinformatics have become the cornerstones of molecular biology. The developing technologies have led to a decrease of the cost per molecular unit analyzed, but at the cost of computer integration and intensification. Many research methods require a reference nucleic acid sequence. Considering the necessary integration of sequencing data and methodology, combining the “omics” approaches can help to elucidate more complex null hypotheses. Here, data processing basics, with an emphasis to commonly used techniques, are summarized. The knowledge gaps are discussed as well as further prospective for integrating next-generation sequencing data

Diamond electro-optomechanical resonators integrated in nanophotonic circuits

Diamond integrated photonic devices are promising candidates for emerging applications in nanophotonics and quantum optics. Here we demonstrate active modulation of diamond nanophotonic circuits by exploiting mechanical degrees of freedom in free-standing diamond electro-optomechanical resonators. We obtain high quality factors up to 9600, allowing us to read out the driven nanomechanical response with integrated optical interferometers with high sensitivity. We are able to excite higher order mechanical modes up to 115 MHz and observe the nanomechanical response also under ambient conditions.Comment: 15 pages, 4 figure

Design and development of a novel spherical UAV

This paper presents the design and system integration of a novel coaxial, flap actuated, spherical UAV for operations in complex environments, such as buildings, caves or tunnels. The spherical design protects the inner components of the vehicle and allows the UAV to roll along the floor if the environment permits. Furthermore, the UAV can land and takeoff from any orientation and come into contact with objects without putting the propellers at risk. Flaps at the base of the sphere will generate roll and pitch moments as opposed to conventional swash plate designs while the coaxial setup will provide the necessary yaw moments and increase in thrust to volume ratio of the system. The flaps, placed below the propellers allow for decoupled roll and pitch control in a thrust vectoring manner. The final result of this design is a well-protected, compact, easily controlled, flexible and agile UAV for operations in complex environments. The spherical UAV was successfully flight tested on a number of occasions with various PD and µ-synthesis robust control systems and was observed to be easily stabilised and resistant to external disturbances to certain extent

Development of a fuel cell hybrid-powered unmanned aerial vehicle

This paper describes the design and development of a hybrid fuel cell/battery propulsion system for a long endurance small UAV. The high level system architecture is presented, followed by the hardware-in-the-loop testing and performance analysis. A high fidelity 6-DoF simulation model of the complete system was developed and used to test the system under different battery state-of-charge. The simulation model included the power manager for the hybrid propulsion system configuration, which is based on rule-based control. The simulation results are compared with the experimental results obtained from the Hardware-in-the-Loop testing