Serum markers of cutaneous melanoma

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Myopathy with Concurrent Tadalafil and Simvastatin

A 48-year-old man, using statin, was admitted to hospital with progressive myalgia after consumption of tadalafil and simvastatin. Muscle pain and penile erection disappeared seven days after interruption of therapy. This case demonstrates the interaction of tadalafil with simvastatin resulting in myopathy. Muscle damage could be attributed to the common metabolic way of these two drugs which is cytochrome P450 isoenzyme system

Efficacy and limits of sildenafil citrate in patients with arterial erectile dysfunction: role of peripheral arterial disease and cardiovascular comorbidities

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The Role of Work in Breast Cancer Patients

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L Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial

Background: Centenarians are characterized by weakness, decreasing mental health, impaired mobility, and poor endurance. L-Carnitine is an important contributor to cellular energy metabolism. Objective: This study evaluated the efficacy of L-carnitine on physical and mental fatigue and on cognitive functions of centenarians. Design: This was a placebo-controlled, randomized, double-blind, 2-phase study. Sixty-six centenarians with onset of fatigue after even slight physical activity were recruited to the study. The 2 groups received either 2 g levocarnitine once daily (n =3D 32) or placebo (n =3D 34). Efficacy measures included changes in total fat mass, total muscle mass, serum triacylglycerol, total cholesterol, HDL cholesterol, LDL cholesterol, Mini-Mental State Examination (MMSE), Activities of Daily Living, and a 6-min walking corridor test. Results: At the end of the study period, the levocarnitine-treated centenarians, compared with the placebo group, showed significant improvements in the following markers: total fat mass (\u961.80 compared with 0.6 kg; P < 0.01), total muscle mass (3.80 compared with 0.8 kg; P < 0.01), plasma concentrations of total carnitine (12.60 compared with \u961.70 \ub5mol; P < 0.05), plasma long-chain acylcarnitine (1.50 compared with \u960.1 \ub5mol; P < 0.001), and plasma short-chain acylcarnitine (6.0 compared with \u961.50 \ub5mol; P < 0.001). Significant differences were also found in physical fatigue (\u964.10 compared with \u961.10; P < 0.01), mental fatigue (\u962.70 compared with 0.30; P < 0.001), fatigue severity (\u9623.60 compared with 1.90; P < 0.001), and MMSE (4.1 compared with 0.6; P < 0.001). Conclusions: Our study indicates that oral administration of levocarnitine produces a reduction of total fat mass, increases total muscular mass, and facilitates an increased capacity for physical and cognitive activity by reducing fatigue and improving cognitive functions