City Blueprints: Baseline Assessments of Sustainable Water Management in 11 Cities of the Future

The necessity of Urban Water Cycle Services (UWCS) adapting to future stresses calls for changes that take sustainability into account. Megatrends (e.g. population growth, water scarcity, pollution and climate change) pose urgent water challenges in cities. In a previous paper, a set of indicators, i.e., the City Blueprint has been developed to assess the sustainability ofUWCS (Van Leeuwen et al.,Wat Resour Manage 26:2177¿2197, 2012). In this paper this approach has been applied in 9 cities and regions in Europe (Amsterdam, Algarve, Athens, Bucharest, Hamburg, Reggio Emilia, Rotterdam, Oslo and Cities of Scotland) and in 2 African cities in Angola (Kilamba Kiaxi) and Tanzania (Dar es Salaam). The assessments showed that cities vary considerably with regard to the sustainability of theUWCS. This is also captured in the Blue City Index (BCI), the arithmetic mean of 24 indicators comprising the City Blueprint (Van Leeuwen et al., Wat Resour Manage 26:2177¿2197, 2012). Theoretically, the BCI has a minimum score of 0 and a maximum score of 10. The actual BCIs in the 11 cities studied varied from 3.31 (Kilamba Kiaxi) to 7.72 (Hamburg). The BCI was positively correlated with the Gross Domestic Product (GDP) per person, the ambitions of the local authorities regarding the sustainability of the UWCS, the voluntary participation index (VPI) and all governance indicators according to the World Bank. The study demonstrated that the variability in sustainability among the UWCS of cities offers great opportunities for short-term and long-term improvements, provided that cities share their best practices.Van Leeuwen, CJ. (2013). City Blueprints: Baseline Assessments of Sustainable Water Management in 11 Cities of the Future. Water resources management. https://doi.org/10.1007/s11269-013-0462-5Bai X (2007) Industrial ecology and the global impacts of cities. 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Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference

Decision support system for infrastructure sustainability in operations

There is an increasing awareness of sustainability and climate change and its impact on infrastructure and engineering asset management in design, construction, and operations. Sustainability rating tools have been proposed and/or developed that provide ratings of infrastructure projects in differing phases of their life cycle on sustainability. This paper provides an overview of decision support systems using sustainability rating framework that can be used to prioritize or select tasks and activities within projects to enhance levels of sustainability outcomes. These systems can also be used to prioritize projects within an organization to optimize sustainability outcomes within an allocated budget