Massive portal vein tumor thrombus from colorectal cancer without any metastatic nodules in the liver parenchyma

Metastatic lesions in the liver derived from colorectal cancer rarely invade the portal vein macroscopically. Portal vein tumor thrombus is commonly associated with hepatocellular carcinoma. Colorectal liver metastases are usually accompanied by microscopic tumor invasion into the intrahepatic portal vein, and the incidence of macroscopic tumor thrombus in the trunk of the portal vein is rare. Here, we provide unique appearance of metastatic colorectal cancer. To the best of our knowledge, macroscopically, the right portal vein filled with the tumor thrombus without any tumor in liver parenchyma has been quite rare

Plasma Free Amino Acid Profiling of Five Types of Cancer Patients and Its Application for Early Detection

BACKGROUND: Recently, rapid advances have been made in metabolomics-based, easy-to-use early cancer detection methods using blood samples. Among metabolites, profiling of plasma free amino acids (PFAAs) is a promising approach because PFAAs link all organ systems and have important roles in metabolism. Furthermore, PFAA profiles are known to be influenced by specific diseases, including cancers. Therefore, the purpose of the present study was to determine the characteristics of the PFAA profiles in cancer patients and the possibility of using this information for early detection. METHODS AND FINDINGS: Plasma samples were collected from approximately 200 patients from multiple institutes, each diagnosed with one of the following five types of cancer: lung, gastric, colorectal, breast, or prostate cancer. Patients were compared to gender- and age- matched controls also used in this study. The PFAA levels were measured using high-performance liquid chromatography (HPLC)-electrospray ionization (ESI)-mass spectrometry (MS). Univariate analysis revealed significant differences in the PFAA profiles between the controls and the patients with any of the five types of cancer listed above, even those with asymptomatic early-stage disease. Furthermore, multivariate analysis clearly discriminated the cancer patients from the controls in terms of the area under the receiver-operator characteristics curve (AUC of ROC >0.75 for each cancer), regardless of cancer stage. Because this study was designed as case-control study, further investigations, including model construction and validation using cohorts with larger sample sizes, are necessary to determine the usefulness of PFAA profiling. CONCLUSIONS: These findings suggest that PFAA profiling has great potential for improving cancer screening and diagnosis and understanding disease pathogenesis. PFAA profiles can also be used to determine various disease diagnoses from a single blood sample, which involves a relatively simple plasma assay and imposes a lower physical burden on subjects when compared to existing screening methods

トクシマシ イシカイ ノ トウニョウビョウ タイサク

Tokushima City Medical Association has founded the committee for the means to prevent diabetesmellitus, because the mortality rate by diabetes mellitus in Tokushima Prefecture remainedranked first for 14 years from 1993 to 2006. It has enlightened a large number of people, such asdiabetic patients and candidates for diabetes, and also healthy citizens in Tokushima for preventingdiabetes mellitus. For this aim, Tokushima City Medical Association has made the home pagenamed Tokushima City Diabetic Network to show clearly the means to prevent diabetes mellitusfor the citizens. By this Web site, the citizens can get a correct knowledge about diabetes mellitus,a useful information about the treatments including exercises, diets and medications, and an informationabout medical institutions by utilizing the search page to receive a proper diabetic treatment.Tokushima City Medical Association held several events, such as Tokushima citizens’extension courses and diabetes forums for the citizens to understand diabetes mellitus clearly.Fortunately, in 2007, Tokushima got out of the first rank of diabetic mortality rate. TokushimaCity Medical Association will continue efforts to prevent diabetes mellitus by approaching the citizensof all ages from various aspects

大腸癌に対する腹腔鏡補助下切除と開腹手術におけるリンパ節郭清の比較検討

目的:大腸癌に対する腹腔鏡補助下大腸切除手術(LAC)と開腹手術(OPEN)のリンパ節郭清が同等の質であるかをリンパ節の採取個数で比較検討した.対象と方法:右半結腸切除,S状結腸切除,直腸高位前方切除が施行された大腸癌手術症例77例.リンパ節採取個数を各リンパ節領域ごとに比較検討した.結果:右半結腸切除21例(LAC:OPEN;12例:9例),S状結腸切除41例(26例:15例),前方切除15例(8例:7例)であった.腫瘍径による補正後の摘出リンパ節個数は(以下LAC:OPEN),右半結腸切除;1群(15.4±1.3:17.5±3.6),主幹2群(8.7±1.0:8.2±0.7),壁在2群(10.8±1.6:15.3±2.9),主幹3群(7.5±1.0:7.6±0.8),S状結腸切除;1群(12.3±1.3:13.1±1.5),主幹2群(8.2±1.2:8.1±1.2),壁在2群(7.0±1.4:5.7±0.9),主幹3群(6.8±1.0:6.4±1.3),前方切除;1群(12.5±2.3:12.4±2.7),主幹2群(9.3±1.4:9.7±2.3),壁在2群(6.8±2.4:5.6±1.3),主幹3群(5.0±0.9:5.3±1.3)であった.考察:LACとOPENで以上の3種類の術式においてリンパ節郭清はほぼ同等であることが示唆された.Aim: This study was conducted to evaluate. The number of dissected lymph nodes between laparoscopyassisted colectomy (LAC) and open colectomy (OPEN). Methods: Seventy-seven patients who underwent hemi-colectomy (LAC: OPEN; 12cases: 9cases), sigmoidectomy (LAC: OPEN; 26cases: 15cases) and high anterior resection (LAC: OPEN; 8cases: 7cases) at Kanagawa Cancer Center were entered in this study. The number of dissected lymph nodes at each N1, paracolic N2, central N2, and central N3 area was compared. Results: In Hemi-colectomy, N1 area was LAC: OPEN =15.4±1.3 : 17.5±3.6 (p = 0.548), Central N2 was 8.8±1.0 : 8.2±0.7 (p = 0.684) , Paracolic N2 was 10.8±1.6 : 15.3±2.9 (p = 0.176), and Central N3 was 7.5±1.0 : 7.6 ± 0.8 (p = 0.966) . In sigmoidectomy, Nl was 12.3±1.3 : 13.1±1.5 (p = 0.675) , Central N2 was 8.2±1.2 : 8.1±1.2 (p = 0.945) , Paracolic N2 was 7.0±1.4 : 5.7±0.9 (p = 0.522) , Central N3 was 6.8±1.0 : 6.4±1.3 (p = 0.808) . In Anterior resection, N1 was 12.5±2.3 : 12.4±2.7 (p = 0.969) , Central N2 was 9.3±1.4 : 9.7±2.3 (p = 0.863) , Paracolic N2 was 6.8±2.4 : 5.6±1.3 (p = 0.689) , and Central N3 was 5.0±0.9 : 5.3±1.3 (p=0.879). Conclusion: The results suggested that quality of lymph node dissection in LAC was equal to that of OPEN