Innovative structural elements of bone plates for fracture osteosynthesis

According to WHO, injuries related to fractures rank 4th in the world. Domestic statistics indicate that every year in Ukraine, about 97,500 Ukrainians are injured due to falls. The bones of the skull, spine and limbs are most injured. High-energy injuries associated with the effect on the human body of high speeds, temperatures, currents, for example, a traffic accident, a fall from a height, a blow, a gunshot wound, constant bone overload, which affects one in three athletes, Crohn's disease, celiac disease, and Cushing's syndrome are factors that lead to fractures. It is clear that it is impossible to insure yourself against a fracture

Modern Approaches to Teaching and Assessment of Higher Education Seekers: A Conceptual Vision

The purpose of the academic paper lies in analysing the viewpoints of various scientists regarding the selection and features of the application of modern approaches to the organization of the educational process, teaching and assessment of the effectiveness of the educational activities of higher education seekers, as well as in practical investigating the main aspects of assessment and educational practice in higher education. In the process of conducting the research, an analytical and bibliographic method has been used in order to study the scientific literature on learning, teaching and assessment issues, as well as a questionnaire survey for the practical clarification of certain aspects of the evaluation and educational process in higher education. Based on the results of the research, the existing works of scholars on the use of modern approaches to the organization of educational activities in higher education and the latest trends in the assessment of the educational process have been analysed

Comparative evaluation of enzyme and biocidal activity of <i>Candida auris</i> and <i>Candida albicans</i>

Introduction. Secreted metabolites with enzymatic or toxic properties are important for effecting of Candida spp pathogenicity. The most clinically significant species is C. albicans. However, invasive infections associated with C. auris have a great significance. The aim of the investigation is comparison the some of enzymatic properties and biocidal activity of C. auris with those of C. albicans. Materials and methods. C. albicans and C. auris strains were used in the study. Growth of micromycetes was detected on nutrient agar, Sabouraud agar or blood agar (with hemolysis presence). The Candida spp. proteinase activity was determined on Difco agar with 2% casein and by cleavage of IgG molecules. Candida lipase activity was assessed on the agar with Tween-20. The viability of buccal epithelial cells after exposure (1 4 h) with candida metabolites was estimated by trypan blue assay. Statistical analysis was performed using RStudio software. Results. The best growth of C. albicans was observed on Sabouraud agar, and C. auris on blood agar. Only C. auris had hemolytic and lipase activity. Protease activity of some C. auris strains was noted. They were able to cleave casein and damage IgG molecules. The metabolites of some Candida strains decreased the viability of epithelial cells while the reduction was more pronounced in the experiments with C. auris (р 0.05). Conclusion. The most suitable medium for C. auris culturing was blood agar. Proteolytic, antiglobulin, hemolytic and lipase activities were observed only for C. auris. C. auris demonstrated more invasive capacity compared to C. albicans. The observed micromycete biocidal activity against buccal epithelial cells was strain-dependent