CONTRIBUTION OF T.D. ZYRYANOVA TO THE STUDY OF THE PROBLEM OF PELVIC BONES INJURIES AND ASSOCIATED COMPLICATIONS

The article presents the results of scientific fundamental and applies researches of Tatyana Dmitrievna Zyryanova on the problem of study of pelvic bones and coxal cavity fractures complicated and non-complicated with bladder, urethra and rectum injuries. T.D. Zyryanova studied and systematized problems on the statistics of this incapacitating pathology, its clinic and diagnostics. She determined indications for conservative and surgical treatment of certain pelvic bones and pelvic waist injury and an algorithm of rehabilitation measures after the treatment. T.D. Zyryanova and co-authors proposed system of transport immobilization at the injuries of pelvic bones and concomitant injuries of internals of cavity of the lesser pelvis

High-temperature ferromagnetism of spsp electrons in narrow impurity bands: Application to CaB6_6

Ferromagnetism with high Curie temperature $T_c$, well above room temperature, and very small saturation moment has been reported in various carbon and boron systems. It is argued that the magnetization must be very inhomogeneous with only a small fraction of the sample ferromagnetically ordered. It is shown that a possible source of high $T_c$ within the ferromagnetic regions is itinerant electrons occupying a narrow impurity band. Correlation effects do not reduce the effective interaction which enters the Stoner criterion in the same way as in a bulk band. It is also shown how, in the impurity band case, spin wave excitations may not be effective in lowering $T_c$ below its value given by Stoner theory. These ideas are applied to CaB$_6$ and a thorough review of the experimental situation in this material is given. It is suggested that the intrinsic magnetism of the B$_2$ and O$_2$ dimers might be exploited in suitable structures containing these elements.Comment: 26 pages, 2 figure

Understanding Human and Ecosystem Dynamics in the Kola Arctic : A Participatory Integrated Study

The Lake Imandra watershed is located in one of the most developed regions in the Arctic - the Kola Peninsula of Russia. Approximately 300 000 people live on the roughly 27 000 km² watershed, making it one of the most densely populated areas of the Arctic. Most of the people are involved in large-scale mineral extraction and processing and the infrastructure needed to support this industry. This paper reports the results of a pilot project staged for the Lake Imandra watershed that has put human dynamics within the framework of ecosystem change to integrate available information and formulate conceptual models of likely future scenarios. The observation period is one of both rapid economic growth and human expansion, with an overall economic decline in the past decade. We are applying the Participatory Integrated Assessment (PIA) approach to integrate information, identify information gaps, generate likely future scenarios, and link scientific findings to the decision-making process. We found an increasingly vulnerable human population in varying states of awareness about their local environment and fully cognizant of their economic troubles, with many determined to attempt maintenance of relatively high population densities in the near future even as many residents of northern Russia migrate south. A series of workshops have involved the citizens and local decision makers in an attempt to tap their knowledge of the region and to increase their awareness about the linkages between the socioeconomic and ecological components.Le bassin hydrographique du lac Imandra est situé dans l'une des régions les plus développées de l'Arctique, soit la presqu'île de Kola, en Russie. Près de 300 000 personnes vivent dans la zone du bassin qui couvre environ 27 000 km², ce qui en fait l'une des régions les plus peuplées de l'Arctique. La plupart des habitants travaillent dans l'extraction et le traitement miniers à grande échelle ainsi que dans l'infrastructure qui soutient cette industrie. Le présent article rapporte les résultats d'un projet pilote mis sur pied pour le bassin du lac Imandra, projet qui a placé la dynamique humaine dans le cadre du changement des écosystèmes, afin d'intégrer l'information disponible et de formuler des modèles conceptuels de scénarios probables dans l'avenir. La période d'observation en est une à la fois de croissance économique et d'expansion démographique rapides, suivie d'un déclin général au cours de la dernière décennie. On a recours à la méthode d'évaluation participative intégrée (EPI) pour intégrer l'information, y dégager des lacunes, générer des scénarios probables dans l'avenir et établir un lien entre résultats de la recherche et processus décisionnel. On a trouvé qu'il y avait une population humaine de plus en plus vulnérable qui était sensibilisée à divers degrés aux problèmes locaux de l'environnement et pleinement consciente des difficultés économiques, population dont une bonne part était fermement décidée à tenter de maintenir à brève échéance des densités de population relativement élevées, alors même que les résidents du nord de la Russie migrent en grand nombre vers le Sud. On a tenu une série d'ateliers avec citoyens et décideurs locaux pour chercher à capter leurs connaissances de la région et à accroître leur sensibilisation aux liens existant entre les composantes socio-économiques et écologiques

Emergence of magnetism in graphene materials and nanostructures

Magnetic materials and nanostructures based on carbon offer unique opportunities for future technological applications such as spintronics. This article reviews graphene-derived systems in which magnetic correlations emerge as a result of reduced dimensions, disorder and other possible scenarios. In particular, zero-dimensional graphene nanofragments, one-dimensional graphene nanoribbons, and defect-induced magnetism in graphene and graphite are covered. Possible physical mechanisms of the emergence of magnetism in these systems are illustrated with the help of computational examples based on simple model Hamiltonians. In addition, this review covers spin transport properties, proposed designs of graphene-based spintronic devices, magnetic ordering at finite temperatures as well as the most recent experimental achievements.Comment: tutorial-style review article -- 18 pages, 19 figure

Features of <i>ESCHERICHIA COLI</i> samples from patients with diarrheal syndrome in the Republic of Guinea

Introduction. Diarrheal diseases are a global public health issue and cause 15% of deaths in children under 5 years old, of which about 80% occur in the regions of Africa and Southeast Asia. According to the Global Enteric Multicentre Study (GEMS) conducted in a number of African countries, one of the leading pathogens of high risk of death in infants and young children is diarrheagenic E. coli (DEC). In recent decades, antimicrobial resistance (AMR) has become globally ubiquitous. The Republic of Guinea urgently needs large-scale studies devoted to assessing DEC distribution and antibiotic resistance. The purpose of the study is to assess the pattern of E. coli infections and to test the susceptibility to antibiotics in strains of diarrheagenic E. coli sampled from individuals residing in the Republic of Guinea. Materials and methods. From 2019 to 2022, we studied 724 samples of faeces of patients with acute diarrhea, among them 72 (9.9%) children aged 1–5 years, 128 (17.7%) children aged 6–17 years, and 524 (72.4%) people aged 18 years and older; a method of polymerase chain reaction (PCR) was applied with the use of the AmpliSense® Escherichioses-FL reagent kit to identify the genetic determinants of DEC: EPEC, EHEC, ETEC, EIEC, and EAgEC (Central Research Institute of Epidemiology of Rospotrebnadzor, Russia). Susceptibility to 15 antimicrobial agents was found by the disc-diffusion method using Mueller–Hinton agar (Russia) and Oxoid discs (UK). Results were interpreted according EUCAST criteria, versions 2019–2022 (https://www.eucast.org/ast_of_bacteria/previous_versions_of_documents). Results. For the period from 2019 to 2022, the percentage of E. coli infections in the etiological pattern of acute intestinal infections amounted to 51.7%. In the age-related manner, DEC was significantly more common in young children aged 0–5 (96.9%, p 0.05) as compared to school age children aged 6–17 (53.9%) and adults (45.6%). In all years of observation, EAgEC strains prevailed, accounting for 38.4%. Other DEC pathotypes, EPEC, ETEC, EIEC and STEC, accounted for 27.2%, 17.5%, 11.8%, and 5.1%, respectively. DEC strains are susceptible to meropenem, amikacin, and nitrofurantoin. The activity of other antibiotics ranged from 11.3% for ampicillin, 28.3% for trimethoprim-sulfamethoxazole, and 34.0% for tetracycline to 73.6% for cephalosporins, 84.0% for aminoglycosides, and 98.1% for fluorinated quinolones. Conclusion. To reduce the burden of diarrheal diseases in the Republic of Guinea, it may be necessary to conduct targeted epidemiological and microbiological studies to identify DEC and monitor the development of antimicrobial resistance of E. coli infection pathogens in the population

Two-dimensional quantum interference contributions to the magnetoresistance of Nd{2-x}Ce{x}CuO{4-d} single crystals

The 2D weak localization effects at low temperatures T = (0.2-4.2)K have been investigated in nonsuperconducting sample Nd{1.88}Ce{0.12}CuO{4-d} and in the normal state of the superconducting sample Nd{1.82}Ce{0.18}CuO{4-d} for B>B_c2. The phase coherence time and the effective thickness $d$ of a conducting CuO_2 layer have been estimated by the fitting of 2D weak localization theory expressions to the magnetoresistivity data for the normal to plane and the in-plane magnetic fields.Comment: 5 pages, 4 postscript figure

What affects the neurovisualisational detection of ischemic stroke?

Introduction. The incidence of stroke is 2.5–3 cases per 1 000 population per year, mortality – 1 case per 1 000 population per year. According to various data, up to 20% of computed tomography (CT) scans performed on the first day do not reveal signs of  an ischemic focus.Aim of the study. To assess the detectability of acute ischemia foci using CT, depending on the location of the foci, the timing of  neuroimaging, the severity of stroke, and other indicators.Material and methods. We analyzed 100 cases of acute cerebrovascular accident (ACV) by ischemic type. The timing of the CT scan, glucose level, coagulogram parameters, NIHSS scores at admission, focus localization, the presence of atherosclerosis of the arteries of the head, and atrial fibrillation were taken into account. Patients were divided into two groups depending on the fact of detection of the focus during the primary tomographic examination. Repeated neuroimaging (magnetic resonance imaging) was performed in 54 patients.Results. In the “CT-negative” group, stem strokes predominated (p = 0.01), patients were younger (р = 0.038), and there were significantly more women than men (р = 0.00006). An increase in glucose over 8 mmol/l, on the contrary, was more often detected in the “CT-positive” group (14 cases in “CT-positive” against 5 cases in “CT-negative” group, p = 0.022). NIHSS scores ≥ 5 were found in 24 patients (47%) in the “CT-positive” group and in 13 patients (26.5%) in the “CT-negative” group (p = 0.034).Conclusions. Cases of stroke that are not detected on CT scan upon admission to the hospital are more common among women, with stem localization, are associated with low NIHSS scores. High glucose levels at admission is associated with the detection of ischemic foci during the initial CT examination

SNOntology: Myriads of novel snornas or just a mirage?

<p>Abstract</p> <p>Background</p> <p>Small nucleolar RNAs (snoRNAs) are a large group of non-coding RNAs (ncRNAs) that mainly guide 2'-O-methylation (C/D RNAs) and pseudouridylation (H/ACA RNAs) of ribosomal RNAs. The pattern of rRNA modifications and the set of snoRNAs that guide these modifications are conserved in vertebrates. Nearly all snoRNA genes in vertebrates are localized in introns of other genes and are processed from pre-mRNAs. Thus, the same promoter is used for the transcription of snoRNAs and host genes.</p> <p>Results</p> <p>The series of studies by Dahai Zhu and coworkers on snoRNAs and their genes were critically considered. We present evidence that dozens of species-specific snoRNAs that they described in vertebrates are experimental artifacts resulting from the improper use of Northern hybridization. The snoRNA genes with putative intrinsic promoters that were supposed to be transcribed independently proved to contain numerous substitutions and are, most likely, pseudogenes. In some cases, they are localized within introns of overlooked host genes. Finally, an increased number of snoRNA genes in mammalian genomes described by Zhu and coworkers is also an artifact resulting from two mistakes. First, numerous mammalian snoRNA pseudogenes were considered as genes, whereas most of them are localized outside of host genes and contain substitutions that question their functionality. Second, Zhu and coworkers failed to identify many snoRNA genes in non-mammalian species. As an illustration, we present 1352 C/D snoRNA genes that we have identified and annotated in vertebrates.</p> <p>Conclusions</p> <p>Our results demonstrate that conclusions based only on databases with automatically annotated ncRNAs can be erroneous. Special investigations aimed to distinguish true RNA genes from their pseudogenes should be done. Zhu and coworkers, as well as most other groups studying vertebrate snoRNAs, give new names to newly described homologs of human snoRNAs, which significantly complicates comparison between different species. It seems necessary to develop a uniform nomenclature for homologs of human snoRNAs in other vertebrates, e.g., human gene names prefixed with several-letter code denoting the vertebrate species.</p

Modeling of traffic flows with due regard to ecological criteria

The article deals with issues of ensuring the reliable and safe city transport system operation through the use of the rational management methods. To make evidence-based management decisions are encouraged to use worked out intelligent decision support system. It is shown that a comprehensive solution of the city transport system management contributes to the sustainable development of the region

The study and management of reliability parameters for automotive equipment using simulation modeling

The author considers the issue of formation research activity competence of future cadets in the system of military education. This issue is up-to-date because of the necessity to increase the quality of military specialists' training. The solution, in the author's opinion, is in realization of the model of scientific and research competence of military school cadets