The dependence of the propositional representation on the specificity of the situation (the case of the mental sphere)

Object: study of the ways of reflection the situations of the mental sphere on the level of propositions by native German speakers Methods: descriptive, comparative, the method of linguistic observation, modeling and interpretation of the substantive structure of a sentence. Results: Established the dependence of the propositional representations character on the specificity of the ontology of situations, the specificity of the sphere of life where the event takes place: the ontological characteristics of the object that is considered in terms of semantics. Practical implications: The results may be used for university courses of the German theoretical grammar and stylistics, the general linguistics, theory and practice of translation, the cognitive linguistics and grammar

ЦИФРОВЫЕ ТЕХНОЛОГИИ КАК АНТИЦИПАТИВНЫЙ КОМПОНЕНТ АНТИКРИЗИСНОГО МЕНЕДЖМЕНТА В УПРАВЛЕНИИ НЕДВИЖИМОСТЬЮ

This article is devoted to specific problems in the field of crisis management of organizations on digitalization-the introduction of digital technologies in the management of real estate as the main production resource.The maintenance of real estate objects requires certain fixed and variable costs (at the same time, regardless of the intensity of use, fixed costs are present in an unchanged form). In this regard, their profitability should be sufficient to ensure positive financial results of economic activities of the organization. Otherwise, a loss is generated from the use of such objects.Objective: Find the best ways to solve the problems associated with the organization’s recovery from the crisis in the field of real estate management based on the introduction of modern digital technologies in economic activities. Justification of the need to re-evaluate the traditional financial and economic paradigm-the model of real estate management in the hotel business.Method or methodology of the work: Analytical and statistical methods of analysis were used in the process of studying the problem.Results: In the global environment, the traditional architecture of crisis management in the hotel business requires a natural transformation. In this regard, the proposed methods (methods) to optimize the management of the property of the organization through the introduction of digital technology, as a modern-conceptual framework of exit from the state of loss of its economic activity to the state of loss of its business.Practical implications: The obtained research results can be used and expediently applied by economic entities engaged in business activities in the field of providing (rendering) services in the field of hotel business to economic entities conducting economic activities based on the introduction of digital technologies. Practice shows that the digital technologies available today can radically change the characteristics of the operation of real estate objects. The introduction of advanced technologies in the financial and economic activities of organizations, in terms of the management of real estate, will allow you to overcome the crisis in a timely and successful manner – to increase the efficiency of their use.Представленная статья посвящена отдельным проблемам в сфере антикризисного управления организации по вопросам цифровизации – внедрения цифровых технологий в управление объектами недвижимости как основного производственного ресурса.Содержание объектов недвижимости требует определенных постоянных и переменных затрат (при этом, вне зависимости от интенсивности использования, постоянные затраты присутствуют в неизменном виде). В этой связи их доходность должна быть достаточной для обеспечения положительных финансовых результатов хозяйственно-экономической деятельности организации. В противном случае формируется убыток от использования таких объектов.Цель работы: найти оптимальные пути решения задач, связанных с выходом организации из кризисного состояния в сфере управления объектами ее недвижимости на основе внедрения в хозяйственно-экономическую деятельность современных цифровых технологий. Обоснование необходимости переоценки традиционной финансово-экономической парадигмы - модели управления объектами недвижимости в сфере гостиничного бизнеса.Метод исследования. В процессе исследования проблемы использовались аналитические и статистические методы анализа.Результаты. В условиях глобальной конъюнктуры традиционная архитектоника антикризисного менеджмента в сфере гостиничного бизнеса требует закономерной трансформации. В этой связи предложены методы (способы) оптимизации управления объектом недвижимости организации на основе внедрения цифровых технологий, как современно-концептуальной основы выхода из состояния убыточности его хозяйственной деятельности для выхода из состояния убыточности его хозяйственной деятельности.Область применения результатов. Полученные результаты исследования могут быть использованы и целесообразно применены экономическими субъектами, осуществляющими предпринимательскую деятельность в области предоставления (оказания) услуг в сфере гостиничного бизнеса экономическим субъектам, ведущих хозяйственную деятельность на основе внедрения цифровых технологий.Практика показывает, что имеющиеся сегодня цифровые технологии способны радикально изменить характеристики эксплуатации объектов недвижимости. Внедрение прогрессивных технологий в финансово-экономическую деятельность организаций, в части касающейся управления объектами недвижимости, позволит своевременно и успешно преодолеть кризисные состояния – повысить эффективность их использования.Метод или методология проведения работы: в статье использованы аналитические и статистические методы анализа

Durvalumab Plus Carboplatin/Paclitaxel Followed by Maintenance Durvalumab With or Without Olaparib as First-Line Treatment for Advanced Endometrial Cancer: The Phase III DUO-E Trial

PURPOSE Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit in mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially in pMMR disease. METHODS This phase III, global, double-blind, placebo-controlled trial randomly assigned eligible patients with newly diagnosed advanced or recurrent endometrial cancer 1:1:1 to: carboplatin/paclitaxel plus durvalumab placebo followed by placebo maintenance (control arm); carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib placebo (durvalumab arm); or carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib (durvalumab + olaparib arm). The primary end points were progression-free survival (PFS) in the durvalumab arm versus control and the durvalumab + olaparib arm versus control. RESULTS Seven hundred eighteen patients were randomly assigned. In the intention-to-treat population, statistically significant PFS benefit was observed in the durvalumab (hazard ratio [HR], 0.71 [95% CI, 0.57 to 0.89]; P = .003) and durvalumab + olaparib arms (HR, 0.55 [95% CI, 0.43 to 0.69]; P < .0001) versus control. Prespecified, exploratory subgroup analyses showed PFS benefit in dMMR (HR [durvalumab v control], 0.42 [95% CI, 0.22 to 0.80]; HR [durvalumab + olaparib v control], 0.41 [95% CI, 0.21 to 0.75]) and pMMR subgroups (HR [durvalumab v control], 0.77 [95% CI, 0.60 to 0.97]; HR [durvalumab + olaparib v control] 0.57; [95% CI, 0.44 to 0.73]); and in PD-L1-positive subgroups (HR [durvalumab v control], 0.63 [95% CI, 0.48 to 0.83]; HR [durvalumab + olaparib v control], 0.42 [95% CI, 0.31 to 0.57]). Interim overall survival results (maturity approximately 28%) were supportive of the primary outcomes (durvalumab v control: HR, 0.77 [95% CI, 0.56 to 1.07]; P = .120; durvalumab + olaparib v control: HR, 0.59 [95% CI, 0.42 to 0.83]; P = .003). The safety profiles of the experimental arms were generally consistent with individual agents. CONCLUSION Carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab with or without olaparib demonstrated a statistically significant and clinically meaningful PFS benefit in patients with advanced or recurrent endometrial cancer

Urban planning approaches to the development of social infrastructure, considering the behavioral preferences of the population (Moscow, Russia)

Sociological studies in urban planning are increasingly being used in planning the placement of facilities across the city, including facilities in the service sector. When conducting a sociological study, the following methods were used: population survey (using online questionnaire), field survey (collection of information about the territory, population, its movements with cultural and domestic purposes, prevailing development, condition of facilities), analysis and generalization of survey results, comparison with data of the official statistics. The results of the study are: the main areas for the development of the social infrastructure of the city and a model of integrated functional and spatial organization of facilities developed taking into account modern behavioral preferences of various socio-demographic groups of the population. On the territory of the city of Moscow (in residential quarters, groups of residential quarters, groups of districts, administrative districts), a new type of facilities is proposed for placement - a multifunctional public complex (MPC) of socio-cultural purpose. The proposed functional composition of MPCs is formed taking into account a survey of the main consumers of services - socio-demographic groups of the population and their behavioral preferences. The main peculiarity of MPCs is the combination of cultural, sports, and additional education facilities that are currently insufficiently present in the urban environment

Bankers without Borders? Implications of Ring-Fencing for European Cross-Border Banks

This paper presents a stylized analysis of the effects of ring-fencing (i.e., different restrictions on cross-border transfers of excess profits and/or capital between a parent bank and its subsidiaries located in different jurisdictions) on cross-border banks. Using a sample of 25 large European banking groups with subsidiaries in Central, Eastern and Southern Europe (CESE), we analyze the impact of a CESE credit shock on the capital buffers needed by the sample banking groups under different forms of ring-fencing. Our simulations show that under stricter forms of ring-fencing, sample banking groups have substantially larger needs for capital buffers at the parent and/or subsidiary level than under less strict (or in the absence of any) ring-fencing.Eastern Europe;Banks;Capital;Credit risk;International banking;Regional shocks;subsidiaries, banking, capital needs, capital adequacy, banking system, capital market, banking statistics, bank reports, capital markets, recapitalization, national bank, capital requirement, bank structures, bank capital, minimum capital requirement, banking sector, capital adequacy ratios, credit policy, tier 1 capital, banking activities, banking sector assets, bank solvency, bank loans, banks ? balance sheets, banking system assets, bank subsidiaries, subordinated debt, return on assets, bank regulators, bankers, bank data, banking regulation, banking sectors, loan loss reserve, government bonds, external capital, bank groups, bank losses, bank exposures, capital control, joint stock

Simulation of Magnetodielectric Effect in Magnetorheological Elastomers

We present the results of numerical simulation of magnetodielectric effect (MDE) in magnetorheological elastomers (MRE)&#8212;the change of effective permittivity of elastomer placed under the external magnetic field. The computer model of effect is based on an assumption about the displacement of magnetic particles inside the elastic matrix under the external magnetic field and the formation of chain-like structures. Such displacement of metallic particles between the planes of capacitor leads to the change of capacity, which can be considered as a change of effective permittivity of elastomer caused by magnetic field (magnetodielectric effect). In the literature, mainly the 2D approach is used to model similar effects. In this paper, we present a new approach of magnetorheological elastomers simulation&#8212;a 3D-model of the magnetodielectric effect with ability to simulate systems of 10 5 particles. Within the framework of the model, three types of particle size distributions were simulated, which gives an advantage over previously reported approaches. Lognormal size distribution was shown to give better qualitative match of the modeling and experimental results than monosized type. The developed model resulted in a good qualitative agreement with all experimental data obtained earlier for Fe-based elastomers. The proposed model is useful to study these novel functional materials, analyze the features of magnetodielectric effect and predict the optimal composition of magnetorheological elastomers for further profound experimental study

A small forward-looking inter-country model (Belarus, Russia and Ukraine)

The paper describes an inter-country model developed on the New Keynesian Phillips curve principle for the economies of Belarus, Russia and Ukraine. Technically the modelling idea has been grounded within the concept of the infinite dimensional vector autoregressive models by Chudik and Pesaran [Chudik A., Pesara M.H., 2007. Infinite-dimensional VAR's and factor models. IZA; DP No. 3206]. The main developments are such that the model is 1) interdependent rather than vector autoregressive, 2) estimated by the generalised method of moments and 3) forward-looking. The primary linkage of the country models is provided through the real effective exchange rates of particular countries, while the secondary linkages are through the Chudik and Pesaran cross-sectional augmentations. A series of Monte Carlo experiments confirms that the small cross-dimension of the model and a possible dominance of one country in the panel (Russia) should not distort the results in a significant way. A series of stochastic simulation experiments made with and without the assumption of observational equivalence principle shows a possible spread of the Dutch Disease from Russia to other countries in the model.Modelling transition economies Inter-country model Forward-looking expectations Dutch Disease

Molecular Determinants of Ethionamide Resistance in Clinical Isolates of <i>Mycobacterium tuberculosis</i>

Background: Ethionamide and prothionamide are now included in group C of the WHO recommended drugs for the treatment of tuberculosis resistant to rifampicin and multidrug-resistant tuberculosis. The clinical relevance of ethionamide and prothionamide has increased with the wide spread of resistant tuberculosis. Methods: We retrospectively analyzed 349 clinical isolates obtained between 2016 and 2020. The susceptibility to ethionamide was tested using both the BactecTM MGITTM 960 system and the SensititreTM MYCOTB plate. Results: The MIC of ethionamide increases with the total resistance of the isolates in a row from susceptible to XDR strains. A significant part of the isolates have a MIC below the breakpoint: 25%, 36%, and 50% for XDR, pre-XDR, and MDR strains. Sensitivity and specificity of detection of mutations were 96% and 86% using MGIT resistance as a reference. Conclusions: Phenotypic methods for testing ethionamide are imperfectly correlated, and the isolates with MIC of 5 mg/L have the intermediate resistance. A significant proportion of resistant TB cases are susceptible and eligible for ethionamide treatment. Resistance could be explained using only analysis of loci ethA, PfabG1, and inhA for most isolates in the Moscow region. The promoter mutation PfabG1 c(-15)t predicts resistance to ethionamide with high specificity but low sensitivity

PROFESSIONALLY ORIENTED DIGITAL TEXTS: ANALYSIS OF GENRES

The purpose of this article is to present the texts of a new nature, i.e. professionally oriented digital texts that are usually read by students of the current generation who use their mobiles and tablets while studying at the universities or institutes. These texts usually contain hyperlinks, audio or video contents that clarify and supplement the additional information of the main source text. The analysis shows that these texts have their special features. The professionally oriented digital texts may be considered as a form of Internet communication in a professional environment that contains different genres. These genres may be different. To identify them, a survey was conducted. It resulted in the following list: mobile applications, articles, online-consulting, professional websites, and professional blogs. The results obtained from the analysis of professionally oriented digital texts can be used by linguists for studying various special discourse genres in other areas

Assessment of Natural Resource Potential of a Territory for Planning of Investment Development and Construction in Suburban Areas

The paper describes the types of assessment and assessment process of the natural environment. A review of judgments about the ecological and geo-ecological assessment of the environment by known academics, environmentalists, physical geographers, geobotanists is made here. In this paper the method of the environmental assessment of natural resource potential within the North-West region of Russia is proposed. Authors divide this method into blocks, which are described in the paper. A produced method for evaluating territory used to calculate the cadastral value of land