3,099 research outputs found

    Multiple Λ\LambdaCDM cosmology with string landscape features and future singularities

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    Multiple Λ\LambdaCDM cosmology is studied in a way that is formally a classical analog of the Casimir effect. Such cosmology corresponds to a time-dependent dark fluid model or, alternatively, to its scalar field presentation, and it motivated by the string landscape picture. The future evolution of the several dark energy models constructed within the scheme is carefully investigated. It turns out to be almost always possible to choose the parameters in the models so that they match the most recent and accurate astronomical values. To this end, several universes are presented which mimick (multiple) Λ\LambdaCDM cosmology but exhibit Little Rip, asymptotically de Sitter, or Type I, II, III, and IV finite-time singularity behavior in the far future, with disintegration of all bound objects in the cases of Big Rip, Little Rip and Pseudo-Rip cosmologies.Comment: LaTeX 11 pages, 10 figure

    Pathomorphological changes in pulmonary vessels at different terms of lethal outcomes of patients with COVID-19

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    Objective: to study the pathomorphological changes in the vessels of the lungs at different times of death in patients with COVID-19. Material and methods: autopsy protocols of 40 deaths from COVID-19 with histological, histochemical examination, and photoregistration. To determine the degree of pulmonary vascular lesions, the authors developed and applied a semi-quantitative assessment scale for the sign based on counting the affected lung vessels in 10 fields of view, expressed as a percentage: no sign – (0%), weak sign + (1-25%), moderate sign ++ (26-50%), expressed sign +++ (51-75%), highly expressed sign ++++ (76-100%). Results: during the first 14 days of the disease, stasis and swelling of individual endotheliocytes were noted in the vessels of the microvasculature. After 15-21 days of the development of COVID-19, signs of alterations in endothelial cells and microthrombosis were observed in microvessels. After 22-28 days of the disease, the phenomena of repair and hyperplasia of endothelial cells were detected. At different times of the development of the disease in the lung tissue, the phenomena of acute respiratory distress syndrome, interstitial pneumonia, and focal pneumofibrosis were observed. Conclusions: the authors believe that COVID-19 is associated with a progressive microvascular endotheliopathy in the lungs which is characterized by swelling, alteration, and later, by hyperplasia, and regeneration of endothelial cells in combination with microthrombosis. Destructive changes in the walls of the microvessels of the lungs have superficial character without the destruction of the reticular frame and basal membranes. Endotheliopathy, microthrombus formation of microvessels of the lungs, and interstitial pneumonia create a vicious circle of severe respiratory failure, which must be taken into account in the clinic to correct the treatment of patients with COVID-19
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