70 research outputs found
Vasorelaxant effect of a phenylethylamine analogue based on schwarzinicine A an alkaloid isolated from the leaves of Ficus schwarzii
N-Phenethyl-1-phenyl-pentan-3-amine (1) is a new compound synthesised as a simplified analogue of schwarzinicine A (2), a natural compound extracted from Ficus schwarzii. Compound 1 differs from compound 2 due to its structural simplification, featuring two phenyl rings without methoxy substitution, as opposed to compound 2, which possesses three 3,4-dimethoxy aromatic rings. Our previous research findings highlighted the calcium-inhibitory effects of compound 2, but the mechanism of action for compound 1 remains unexplored, serving as the primary focus of this study. Building upon our earlier research, this study aimed to elucidate compound 1's calcium-modulating potential by using rat-isolated aortae in an organ bath set-up and HEK cells expressing hTRPC channels with the fluorometric assay to measure calcium influx. Compound 1 elicited a vasorelaxation response (Emax 111.4%) similar to its parent compound 2 (Emax 123.1%), and inhibited hTRPC3-, hTRPC4-, hTRPC5-, and hTRPC6-mediated calcium influx into HEK cells with IC50 values of 6, 2, 2, 5 µM, respectively. Compound 1 has a similar pharmacological profile as its parent compound 2, whereby it exerts a vasorelaxant effect by attenuating calcium influx and inhibits multiple TRPC channels
Anaemia in National Service Registrants in Singapore.
Annals of the Academy of Medicine Singapore193359-36
Trends in mortality, incidence, hospitalisation, cardiac procedures and outcomes of care for coronary heart disease in Singapore, 1991-1996
Annals of the Academy of Medicine Singapore283395-401AAMS
Thermolysis of the osmium-antimony clusters Os3(CO) 11(SbMe2Ar): Higher nuclearity clusters and arrested ortho metalation
10.1021/om0508132Organometallics251250-259ORGN
Vertebral collapse in acute lymphoblastic leukaemia: Case reports
Journal of the Singapore Paediatric Society283-4257-261SPSJ
Simultaneous ST-segment elevation in lead V1 and depression in lead V2. A discordant ECG pattern indicating right ventricular infarction
Journal of Electrocardiology273203-207JECA
Topology supported finite element method analysis of catheter/guidewire navigation in reconstructed coronary arteries
Computers in Cardiology529-532COCA
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