Terrorism and Tourism in the Asia Pacific Region: Is Travel and Tourism in a New World After 9/11?

The paper reviews trends in travel and tourism in selected Asia Pacific countries before and after the terrorist attacks of September 11, 2001 (9/11) to consider the question of whether or not global tourism has fundamentally changed since 9/11. Tourism is an important economic sector in several Asia Pacific countries and is a "fragile" industry in that it is highly susceptible to external shocks such as wars, outbreaks of deadly contagious diseases, incidents of terrorism, and so on. The first part of the paper presents a stylized picture of industry response following terrorist incidents and other major negative shocks to tourism, and reviews international tourist arrivals at selected Asia Pacific destinations. A richer body of data available for Japan and the U.S. allows examination of the extent of substitution between domestic and international travel, and the impact of changed travel behavior on tourist spending. The paper finds that there has been significant substitution of domestic travel for overseas travel by nationals of both countries after 9/11, and that this has had a dramatic impact on the Hawaii tourism market. The paper explores some of the reasons for the differences observed in post-9/11 travel recoveries across Asia Pacific countries.

The Impact of 9/11 and Other Terrible Global Events on Tourism in the U.S. and Hawaii

This paper reviews recent trends in travel and tourism in the U.S. and Hawaii to ascertain how the terrorist attacks of 9/11 and subsequent terrible global events affected their tourism flows and the manner and pace of their recovery. We note that tourism in the U.S. has not fully recovered from 9/11 and other international shocks; indeed recovery of international travel to the U.S. may be a long way off. By contrast, Hawaii tourism is enjoying robust growth in the aftermath of 9/11 as growth in tourist arrivals from the U.S. mainland has more than offset declines in Japanese and other international visitors. We suggest that Hawaii's current tourism boom is in part explained by the diversion of U.S. travel from foreign travel. The paper demonstrates the usefulness of vector error correction models to generate dynamic visitor forecasts which we use to ascertain whether tourism in Hawaii has fully recovered from 9/11 and other terrible international events. The paper considers policy options for facilitating the recovery of international tourism to the U.S.

The Impact of 9/11 and Other Terrible Global Events on Tourism in the U.S. and Hawaii

This paper reviews recent trends in travel and tourism in the U.S. and Hawaii to ascertain how the terrorist attacks of 9/11 and subsequent terrible global events affected their tourism flows and the manner and pace of their recovery. We note that tourism in the U.S. has not fully recovered from 9/11 and other international shocks; indeed recovery of international travel to the U.S. may be a long way off. By contrast, Hawaii tourism is enjoying robust growth in the aftermath of 9/11 as growth in tourist arrivals from the U.S. mainland has more than offset declines in Japanese and other international visitors. We suggest that Hawaiis current tourism boom is in part explained by the diversion of U.S. travel from foreign travel. The paper demonstrates the usefulness of vector error correction models to generate dynamic visitor forecasts which we use to ascertain whether tourism in Hawaii has fully recovered from 9/11 and other terrible international events. The paper considers policy options for facilitating the recovery of international tourism to the U.S.Tourism, Terrorism, Impact, Recovery

The Impact of Approved Destination Status on Chinese Travel Abroad: An Economic Analysis

Since the early 1990s China’s government has negotiated Approved Destination Status (ADS) with 120 countries. The agreements allow government-approved travel agencies to market group tours and obtain visas in bulk to ADS destinations. We apply a gravity model framework to analyze how ADS has affected Chinese outbound tourist travel from China using Chinese visitor arrivals data from 61 main foreign destinations of mainland Chinese tourists (which account for vast majority of international departures from China) from 1995 to 2005. Fixed effects estimates indicate ADS resulted in significant increases in arrivals from China (averaging 52 percent over three years). We also find evidence of travel diversion as more countries received ADS.China Outbound Travel, Approved Destination Status, Gravity Model, Tourism, International Agreements, Travel Liberalization

Biomarkers in acute coronary syndromes and their role in diabetic patients

Diabetic patients with acute coronary syndromes are at high risk for cardiovascular complications but risk stratification in these patients remains challenging. Regularly, diabetic patients have a less typical clinical presentation, which could lead to delayed diagnosis and subsequent delayed initiation of treatment. Since diabetic patients derive particular benefit from aggressive anti-platelet therapy, early diagnostic and therapeutic risk stratification of these patients is of critical importance to improve their adverse outcome. Although the electrocardiogram remains a pivotal diagnostic tool in the evaluation of patients suspected of having an acute coronary syndrome, only significant STsegment changes provide reasonable prognostic information. Therefore, repeated assessment of circulating protein biomarkers represents a valuable diagnostic tool for improving efficacy and safety of decision-making in these patients. The combined use of biomarkers reflecting distinct pathophysiological aspects, such as myocardial necrosis, vascular inflammation, oxidative stress and neurohumoral activation, may significantly improve triage of patients with chest pain. These tools may identify those patients that are at particularly high risk for short-term and/or long-term cardiovascular events. Eventually, tailored medical and interventional treatment of diabetic patients should help to prevent these cardiac events in a cost-effective manner

Extremely Sub-wavelength Planar Magnetic Metamaterials

We present highly sub-wavelength magnetic metamaterials designed for operation at radio frequencies (RFs). A dual layer design consisting of independent planar spiral elements enables experimental demonstration of a unit cell size (a) that is ~ 700 times smaller than the resonant wavelength ({\lambda}0). Simulations indicate that utilization of a conductive via to connect spiral layers permits further optimization and we achieve a unit cell that is {\lambda}0/a ~ 2000. Magnetic metamaterials are characterized by a novel time domain method which permits determination of the complex magnetic response. Numerical simulations are performed to support experimental data and we find excellent agreement. These new designs make metamaterial low frequency experimental investigations practical and suggest their use for study of magneto-inductive waves, levitation, and further enable potential RF applications.Comment: 5 pages, 4 figure

Modeling and simulation of commercial aircraft electrical systems

In this thesis a modeling and simulation based methodology is proposed to study the general power flow and dynamics of commercial aircraft electrical systems. This was done by creating a toolset composed of the crucial elements to model an aircraft electrical system that consists of power sources, power conversion, power distribution, and electrical loads. The considerations for the component models were modularity, computation time, accuracy, ease of use, and an integration with other aircraft system components. The individual components were modeled to be interchangeable and interface with the other components. Several techniques were used to simplify each component model and reduce the computational resources while still maintaining the component dynamic behavior and interactions. A MATLAB/Simulink platform was used to build the components because it is a resource available to others. An average model approach was used for some of the components because the "fast" dynamics will appear as transients to the other aircraft systems like the thermal system. The component models were used to model and simulate the electrical system in faster than real time for a real mission. The sample aircraft architecture that was modeled was that of the Boeing 737, a typical twin-engine aircraft. Aside from the components that were modeled, the various simulations were performed using a sample flight profile of an aircraft, which details parameters of flight over time, and an engine model developed in Numerical Propulsion System Simulation (NPSS). The following scenarios were simulated: no fault or failure, temporary disconnection between generator and load, and single-generator failure. All of the simulations were conducted using a similar flight profile with small adjustments for the single-generator failure scenario

Meta-Analysis of Adipose Tissue Derived Cell-Based Therapy for the Treatment of Knee Osteoarthritis.

Osteoarthritis (OA) is a degenerative disorder associated with cartilage loss and is a leading cause of disability around the world. In old age, the capacity of cartilage to regenerate is diminished. With an aging population, the burden of OA is set to rise. Currently, there is no definitive treatment for OA. However, cell-based therapies derived from adipose tissue are promising. A PRISMA systematic review was conducted employing four databases (MEDLINE, EMBASE, Cochrane, Web of Science) to identify all clinical studies that utilized adipose tissue derived mesenchymal stem cells (AMSCs) or stromal vascular fraction (SVF) for the treatment of knee OA. Eighteen studies were included, which met the inclusion criteria. Meta-analyses were conducted on fourteen of these studies, which all documented WOMAC scores after the administration of AMSCs. Pooled analysis revealed that cell-based treatments definitively improve WOMAC scores, post treatment. These improvements increased with time. The studies in this meta-analysis have established the safety and efficacy of both AMSC therapy and SVF therapy for knee OA in old adults and show that they reduce pain and improve knee function in symptomatic knee OA suggesting that they may be effective therapies to improve mobility in an aging population

Synovium-Derived Mesenchymal Stem Cell Transplantation in Cartilage Regeneration: A PRISMA Review of in vivo Studies.

Articular cartilage damaged through trauma or disease has a limited ability to repair. Untreated, focal lesions progress to generalized changes including osteoarthritis. Musculoskeletal disorders including osteoarthritis are the most significant contributor to disability globally. There is increasing interest in the use of mesenchymal stem cells (MSCs) for the treatment of focal chondral lesions. There is some evidence to suggest that the tissue type from which MSCs are harvested play a role in determining their ability to regenerate cartilage in vitro and in vivo. In humans, MSCs derived from synovial tissue may have superior chondrogenic potential. We carried out a systematic literature review on the effectiveness of synovium-derived MSCs (sMSCs) in cartilage regeneration in in vivo studies in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. Twenty studies were included in our review; four examined the use of human sMSCs and 16 were conducted using sMSCs harvested from animals. Most studies reported successful cartilage repair with sMSC transplantation despite the variability of animals, cell harvesting techniques, methods of delivery, and outcome measures. We conclude that sMSC transplantation holds promise as a treatment option for focal cartilage defects. We believe that defining the cell population being used, establishing standardized methods for MSC delivery, and the use of objective outcome measures should enable future high quality studies such as randomized controlled clinical trials to provide the evidence needed to manage chondral lesions optimally

Infrapatellar fat pad adipose-derived stem cells co-cultured with articular chondrocytes from osteoarthritis patients exhibit increased chondrogenic gene expression.

AIM: The variable results in clinical trials of adipose tissue-derived stem cells (ASCs) for chondral defects may be due to the different ex vivo culture conditions of the ASCs which are implanted to treat the lesions. We sought to determine the optimal in vitro chondrocyte co-culture condition that promotes infrapatellar fat pad-derived (IFPD) ASC chondrogenic gene expression in a novel co-culture combination. METHODS: In our study, we utilized an in vitro autologous co-culture of IFPD ASCs and articular chondrocytes derived from Kellgren-Lawrence Grade III/IV osteoarthritic human knee joints at ASC-to-chondrocyte seeding log ratios of 1:1, 10:1, and 100:1. Gene expression following in vitro co-culture was quantified by RT-qPCR with a panel comprising COL1A1, COL2A1, COL10A1, L-SOX5, SOX6, SOX9, ACAN, HSPG2, and COMP for chondrogenic gene expression. RESULTS: The chondrogenic gene expression profiles from co-cultures were greater than would be expected from an expression profile modeled from chondrocyte and ASC-only monocultures. Additionally, chondrogenic gene expression decreased with increasing ASC-to-chondrocyte seeding ratios. CONCLUSIONS: These findings provide insight into the mechanisms underlying clinical ASC therapies and signifies that IFPD ASCs pre-conditioned by chondrocyte co-culture may have improved chondrogenic potential for cartilage repair. This model can help further understand IFPD ASCs in chondral and osteochondral repair and the chondrogenic pathways involved. Video Abstract