12 research outputs found
Ruthenium Hydride Complex Supported on Gold Nanoparticle Cored Triazine Dendrimers for C–C Coupling Reactions
In
this work, the unusual ability of a ruthenium hydride catalyst,
[RuHClÂ(PPh<sub>3</sub>)<sub>3</sub>CO], supported on gold nanoparticle
cored triazine dendrimers in the Suzuki–Miyaura cross-coupling
reaction and also in the synthesis of diaryl ketones is reported.
[Ru-H@AuNPs-TD] was characterized by Fourier transform infrared spectroscopy,
CHNS, TEM, SEM, ICP, and TGA analyses. The ruthenium hydride catalyst
was used as a heterogeneous catalyst for the C–C coupling reactions
of aryl halides with phenylboronic acids, and the biphenyl derivatives
were produced in good to excellent yields. On the other hand, this
catalytic system was applied for synthesis of diaryl ketones by the
reaction of phenylboronic acids with substituted benzaldehydes. Moreover,
this catalyst can be well-dispersed in the reaction medium, conveniently
separated from the reaction mixture, and reused several times without
significant loss of its activity
Copper Dithiol Complex Supported on Silica Nanoparticles: A Sustainable, Efficient, and Eco-friendly Catalyst for Multicomponent Click Reaction
Silica-nanoparticle-supported
copper-containing ionic liquid (SNIL-CuÂ(II))
provided a highly stable, active, reusable, spherical, and solid-phase
catalyst for click chemistry. The SNIL-CuÂ(II) catalyst was readily
prepared from 1,2-<i>bis</i>(4-pyridylthio)Âethane immobilized
on silica nanoparticles modified with 3-chloropropyltrimethoxysilane
and CuÂ(OTf)<sub>2</sub>, and the morphology, structure, and properties
of nanoparticles were investigated through different analytical tools.
This catalytic system showed high activity in a one-pot synthesis
of 1,4-disubstituted 1,2,3-triazoles by click reactions between a
variety of alkynes, organic halides, and sodium azide at room temperature
in aqueous polyethylene glycol as a green medium with a high turnover
frequency (up to 7920 h<sup>–1</sup>). Moreover, the SNIL-CuÂ(II)
was also used as an efficient catalyst for the preparation of a series
of multifold 1,4-disubstituted 1,2,3-triazoles. Also, this unique
catalyst was readily reused without any decrease in its catalytic
activity to give the corresponding triazoles quantitatively
Novel Multicomponent Synthesis of Pyridine–Pyrimidines and Their Bis-Derivatives Catalyzed by Triazine Diphosphonium Hydrogen Sulfate Ionic Liquid Supported on Functionalized Nanosilica
In this Research Article, we report
an efficient synthesis of 1,3-dimethyl-5-aryl-7-(pyridine-3(2)(4)-yl)Âpyrimidine-2,4Â(1<i>H</i>,3<i>H</i>)-diones via a three-component reaction
of aryl aldehydes, 1,3-dimethyl-6-aminouracil and carbonitriles in
the presences of triazine diphosphonium hydrogen sulfate ionic liquid
supported on functionalized nanosilica (APTADPHS-<i>n</i>SiO<sub>2</sub>) as a reusable catalyst under microwave irradiation
and solvent-free conditions. The bis-derivatives of pyridine–pyrimidines
were also efficiently prepared from dialdehydes and dinitriles. In
addition, 3-methyl-1<i>H</i>-pyrazole-5-amine was used successfully
instead of 1,3-dimethyl-6-aminouracil under the same conditions to
afford the corresponding products in high yields. The catalyst can
be reused at least five times without any significant loss of its
activity. The easy recovery, reusability and excellent activity of
the catalyst as well as easy workup are other noteworthy advantages
of this method
A Novel <i>pseudo</i>-Four-Component Domino Reaction for the Synthesis of Naphtho[2,1‑<i>b</i>]furan-2(1<i>H</i>)‑ones Using a Nanocatalyst
In
this article, an original one-pot method is utilized to synthesize
a variety of derivatives of naphthoÂ[2,1-<i>b</i>]Âfuran-2Â(1<i>H</i>)-one <i>via</i> a <i>pseudo</i>-four-component
domino reaction of aryl aldehydes, acetic anhydride, hippuric acids,
and 2-naphthols catalyzed by HSW@SPIONs. This reaction illustrates
an array of attractive features including, with particular interest
in this report, a convenient and unique process of creating and utilizing
a powerful recyclable nanocatalyst
A combined computational/experimental study on HSA binding of two water-soluble Schiff base ligands derived from pyridine derivative and ethylendiamine
A combined computational/experimental study on HSA binding of two water-soluble Schiff base ligands derived from pyridine derivative and ethylendiamin
Diphenhydramine Hydrochloride–CuCl as a New Catalyst for the Synthesis of Tetrahydrocinnolin-5(1<i>H</i>)‑ones
The current study
deals with the synthesis and characterization
of a novel catalyst made from diphenhydramine hydrochloride and CuCl
([HDPH]Cl–CuCl). The prepared catalyst was thoroughly characterized
using various techniques, such as 1H NMR, Fourier transform-infrared
spectroscopy, differential scanning calorimetry, and thermogravimetric
analysis and derivative thermogravimetry. More importantly, the observed
hydrogen bond between the components was proven experimentally. The
activity of this catalyst was checked in the preparation of some new
derivatives of tetrahydrocinnolin-5(1H)-ones via a multicomponent reaction between dimedone, aromatic
aldehydes, and aryl/alkyl hydrazines in ethanol as a green solvent.
Also, for the first time, this new homogeneous catalytic system was
effectively used for the preparation of unsymmetric tetrahydrocinnolin-5(1H)-one derivatives as well as mono- and bis-tetrahydrocinnolin-5(1H)-ones from
two different aryl aldehydes and dialdehydes, respectively. The effectiveness
of this catalyst was further confirmed by the preparation of compounds
containing both tetrahydrocinnolin-5(1H)-one and
benzimidazole moieties from dialdehydes. The one-pot operation, mild
conditions, rapid reaction, and high atom economy, along with the
recyclability and reusability of the catalyst, are other notable features
of this approach
Diastereoselective Synthesis of Symmetrical and Unsymmetrical Tetrahydropyridines Catalyzed by Bi(III) Immobilized on Triazine Dendrimer Stabilized Magnetic Nanoparticles
Unsymmetrical
1,2,5,6-tetrahydropyridine-3-carboxylates were obtained for the first
time from a five-component Fe<sub>3</sub>O<sub>4</sub>@TDSN-BiÂ(III)-catalyzed
reaction of aryl aldehydes, aryl amines, and ethyl acetoacetate. This
magnetically separable catalyst enabled the selective incorporation
of two different aryl amines or two different aryl aldehydes into
the product, and provided excellent yields, short reaction times,
mild reaction conditions, satisfactory catalyst recyclability, and
low catalyst loading
Diastereoselective Synthesis of Symmetrical and Unsymmetrical Tetrahydropyridines Catalyzed by Bi(III) Immobilized on Triazine Dendrimer Stabilized Magnetic Nanoparticles
Unsymmetrical
1,2,5,6-tetrahydropyridine-3-carboxylates were obtained for the first
time from a five-component Fe<sub>3</sub>O<sub>4</sub>@TDSN-BiÂ(III)-catalyzed
reaction of aryl aldehydes, aryl amines, and ethyl acetoacetate. This
magnetically separable catalyst enabled the selective incorporation
of two different aryl amines or two different aryl aldehydes into
the product, and provided excellent yields, short reaction times,
mild reaction conditions, satisfactory catalyst recyclability, and
low catalyst loading
One-Pot Three-Component Synthesis of Pyrano [3,2‑<i>b</i>]pyrazolo[4,3‑<i>e</i>]pyridin-8(1<i>H</i>)‑ones
An efficient one-pot synthesis of
novel pyranoÂ[3,2-<i>b</i>]ÂpyrazoloÂ[4,3-<i>e</i>]Âpyridin-8Â(1<i>H</i>)-ones
via three-component condensation of kojic acid, 1-<i>H</i>-pyrazol-5-amines and aldehydes in the presence of a catalytic amount
of ZnÂ(OTf)<sub>2</sub> followed by H<sub>2</sub>O<sub>2</sub>-mediated
oxidation is reported. Furthermore, the synthesis of 1′<i>H</i>-spiroÂ[indoline-3,4′-pyranoÂ[2,3-<i>b</i>]ÂpyrazoloÂ[3,4-<i>e</i>]Âpyridine]-2,8′(9′<i>H</i>)-diones were chosen for the library validation
Copper Immobilized on Nanosilica Triazine Dendrimer (Cu(II)-TD@nSiO<sub>2</sub>)‑Catalyzed Regioselective Synthesis of 1,4-Disubstituted 1,2,3-Triazoles and Bis- and Tris-Triazoles via a One-Pot Multicomponent Click Reaction
An efficient, atom-economical,
and regioselective synthesis of
a wide range of 1,4-disubstituted 1,2,3-triazoles in excellent yields
has been achieved via a one-pot three-component reaction of alkynes
and sodium azide with organic halides or α-bromo ketones catalyzed
by CuÂ(II)-TD@nSiO<sub>2</sub>/sodium ascorbate at room temperature.
This catalytic system also showed excellent activity in the synthesis
of bis- and tris-1,4-substituted 1,2,3-triazoles. Moreover, the catalyst
could be recycled and reused for seven cycles without any loss in
its catalytic activity