2 research outputs found
Formulation of the extract of the stem bark of Alstonia boonei as tablet dosage form
Purpose: To formulate the extracts of the stem bark of Alstonia
boonei , an important antimalarial herb, into tablet dosage form.
Methods: Tablets were formulated using direct compression and wet
granulation methods. The mechanical properties of the tablets were
assessed using crushing strength and friability and the crushing
strength:friability ratio (CSFR) while drug release properties were
evaluated using disintegration and dissolution times. Results: There
were statistically significant (p<0.01) differences in the CSFR
values and drug release properties of A. boonei tablets prepared by
both methods. The differences depended on the type and concentration of
excipient and binder employed in the formulation. Conclusions: The
method of preparation of the A. boonei tablets needs to be carefully
selected to ensure the production of tablets with adequate bond
strength to withstand the rigours of handling and at the same time
release the active compound (s) for biological action