Age-Related Differences in Restricted Repetitive Behaviors in Autism Spectrum Disorders

Restricted repetitive behaviors (RRBs) were examined in a large group of children, adolescents and adults with ASD in order to describe age-related patterns of symptom change and association with specific contextual factors, and to examine if the patterns of change are different for the various types of RRBs. Over 700 individuals with ASD were rated on the Repetitive Behavior Scale – Revised. RRBs were less frequent and less severe among older than younger individuals, corroborating that autism symptoms abate with age. Our findings further suggest that repetitive behaviors are a heterogeneous group of behaviors, with the subtypes of RRBs having their own individual patterns across the lifespan, and in some cases, a differential association with age depending on intellectual functioning

The Symptoms of Autism Spectrum Disorders in Adolescence and Adulthood

This article describes the symptoms of autism spectrum disorders (ASD) manifested by 405 individuals between the ages of 10 and 53 years, all of whom had an ASD diagnosis. Data were collected using the Autism Diagnostic Interview–Revised (ADI-R) to assess the pattern of autism symptoms in adolescence and adulthood. Findings include that although virtually all sample members met the criteria for Autistic Disorder earlier in their childhood, just over half (54.8%) would have met autism criteria if current scores were used to complete the diagnostic algorithm; that adolescents were more likely to improve in the Reciprocal Social Interaction domain than the adults, whereas the adults were more likely to improve in the Restricted, Repetitive Behaviors and Interests domain, and there were no differences in severity of symptoms between cohorts in the Communication domain; and that individual symptoms showed unique trajectories, with greatest symptom abatement between lifetime and current ADI-R ratings for speaking in at least three-word phrases and the least symptom improvement for having friendships. Findings were interpreted in the context of life course development, reformulations of diagnostic criteria, and changing service contexts for individuals with autism spectrum disorders.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44621/1/10803_2004_Article_474978.pd

Objectum sexuality: a sexual orientation linked with autism and synaesthesia

Objectum-sexuality (OS) is a sexual orientation which has received little attention in the academic literature. Individuals who identify as OS experience emotional, romantic and/or sexual feelings towards inanimate objects (e.g. a bridge, a statue). We tested 34 OS individuals and 88 controls, and provide the first empirical evidence that OS is linked to two separate neurodevelopmental traits - autism and synaesthesia. We show that OS individuals possess significantly higher rates of diagnosed autism and significantly stronger autistic traits compared to controls, as well as a significantly higher prevalence of synaesthesia, and significant synaesthetic traits inherent in the nature of their attractions. Our results suggest that OS may encapsulate autism and synaesthesia within its phenomenology. Our data speak to debates concerning the biological underpinnings of sexuality, to models of autism and synaesthesia, and to psychological and philosophical models of romantic love

Associated features in females with an FMR1 premutation

Abstract Changes in the fragile X mental retardation 1 gene (FMR1) have been associated with specific phenotypes, most specifically those of fragile X syndrome (FXS), fragile X tremor/ataxia syndrome (FXTAS), and fragile X primary ovarian insufficiency (FXPOI). Evidence of increased risk for additional medical, psychiatric, and cognitive features and conditions is now known to exist for individuals with a premutation, although some features have been more thoroughly studied than others. This review highlights the literature on medical, reproductive, cognitive, and psychiatric features, primarily in females, that have been suggested to be associated with changes in the FMR1 gene. Based on this review, each feature is evaluated with regard to the strength of evidence of association with the premutation. Areas of need for additional focused research and possible intervention strategies are suggested

The Evolution of the Wisconsin Institutes for Discovery

In 2008, construction will begin on the Wisconsin Institutes for Discovery. These twin centers -- the private Morgridge Institute for Research (MIR) and the public Wisconsin Institute for Discovery (WID) -- will serve as a hub for interdisciplinary research on the UW-Madison campus. For instance, WID will facilitate research and learning in the biological sciences by engaging a diversity of researchers from across the campus in an interdisciplinary, collaborative environment. Ultimately, the institute will produce scientific advances that can be translated into biomedical and related applications. As WID Interim Director, Marsha Mailick Seltzer has been highly involved in the development of both WID and MIR. Join her for a discussion of the fundamental questions and issues that planners have encountered throughout this process. Topics will include public-private partnerships, public service and outreach, relationships with industrial and investment communities, undergraduate experiences, space and architecture, urban design, and others

Stability and Change in Health, Functional Abilities, and Behavior Problems Among Adults With and Without Down Syndrome

Changes in health, functional abilities, and behavior problems among 150 adults with Down syndrome and 240 adults with mental retardation due to other causes were examined with seven assessments over a 9-year period. Adults were primarily younger than 40, the age at which declines begin to be evident in individuals with Down syndrome. Adults with Down syndrome were advantaged in their functional abilities and lack of behavior prob-lems, comparable in health, and exhibited comparable rates of change on these measures as adults with mental retardation due to other causes. Placement out of the parental home and parental death were predictors of change in health, functional abilities, and behavior problems. The past 50 years have been a time of re-markable change for individuals with Down syn-drome, as medical breakthroughs and improve-ments in services have extended their life expec-tancy dramatically (Bittles & Glasson, 2004; Ey-man & Borthwick-Duffy, 1994; Glasson et al., 2002). Significant research attention has been fo-cused on the health and longevity of adults with Down syndrome in the modern era of antibiotics, easier access to health care and life-saving surger-ies, and community rather than institutional res

Change in depressive symptoms among daughter caregivers: An 18-month longitudinal study.

This longitudinal study investigates, over an 18-month period, the caregiving experience of a probability sample of 115 daughters who provided care to an aging parent. The levels of depressive symptoms manifested by these daughters were relatively low, with only 23.5% scoring in the clinical range during the study. Nevertheless, there was substantive change in depressive symptoms among the daughters during the 18 months. Daughters with higher levels of mastery were more likely to use problem-focused coping strategies, which led to reductions in depression, whereas daughters with lower levels of mastery were more likely to use emotion-focused coping, which led to increased levels of depression. Mastery was higher when the caregiving role was shared with a sibling; it was lower if the daughter had other caregiving responsibilities and if the parent care recipient had elevated levels of behavior problems. This longitudinal study investigates the caregiving experience of daughters who provide care to an aging parent, over an 18-month period. George (1990) and Miller (1997) have questioned whether there is a need for additional research on family caregiving, given the burgeoning literature of the 1980s an