LSS, a problem solving skill for graduates and SMEs: Case Study of investigation in a UK Business School curriculum

Purpose - This research aims to investigate the feasibility of a systematic Lean Six Sigma (LSS) education through the curriculum of business schools to respond to the existing gap between the graduate’s expectation of employability and skill requirements by the Small and Medium Sized Enterprises (SMEs). Design/approach/methodology - One UK business school has been used as a case study to conduct an extensive module and programme review followed by a semi-structured interview with the potentially suitable core and programme-specific module leaders and also the comparative Analysis between content of these modules and the existing LSS high-street training themes. Findings – The result revealed a high potential of the existing modules in the business schools equivalent to the private sector training providers to increase the level of LSS problem solving knowledge and skill for all graduates and improve their employability and productivity for the SMEs. Practical implications/limitations – This research has been carried out in a single UK–based Business School through a qualitative approach. A further in-depth analysis in a broader scale is required to investigate the practical implications in a better way. Originality/Value – The result of this study highlights the role of LSS to reduce the knowledge and skill gap between the business schools as the source of the explicit knowledge, graduates as the knowledge and skill bearer, and SMEs as the knowledge and skill users

The UV filtering potential of drop-casted layers of frustules of three diatom species

Abstract Diatoms are in focus as biological materials for a range of photonic applications. Many of these applications would require embedding a multitude of diatoms in a matrix (e.g. paint, crème or lacquer); however, most studies on the photonic and spectral properties of diatoms frustules (silica walls) have been carried out on single cells. In this study, for the first time, we test the spectral properties of layers of frustules of three diatom species (Coscinodiscus granii, Thalassiosira punctifera and Thalassiosira pseudonana), with special focus on transmission and reflectance in the UV range. The transmittance efficiency in the UV A and B range was: T. pseudonana (56–59%) >C. granii (53–54%) >T. punctifera (18–21%) for the rinsed frustules. To investigate the underlying cause of these differences, we performed X-ray scattering analysis, measurement of layer thickness and microscopic determination of frustule nanostructures. We further tested dried intact cells in the same experimental setup. Based on these data we discuss the relative importance of crystal structure properties, nanostructure and quantity of material on the spectral properties of diatom layers. Characterization of the UV protection performance of layers of diatom frustules is of central relevance for their potential use as innovative bio-based UV filters

3D Polymer Architectures for the Identification of Optimal Dimensions for Cellular Growth of 3D Cellular Models

Organ-on-chips and scaffolds for tissue engineering are vital assay tools for pre-clinical testing and prediction of human response to drugs and toxins, while providing an ethical sound replacement for animal testing. A success criterion for these models is the ability to have structural parameters for optimized performance. Here we show that two-photon polymerization fabrication can create 3D test platforms, where scaffold parameters can be directly analyzed by their effects on cell growth and movement. We design and fabricate a 3D grid structure, consisting of wall structures with niches of various dimensions for probing cell attachment and movement, while providing easy access for fluorescence imaging. The 3D structures are fabricated from bio-compatible polymer SZ2080 and subsequently seeded with A549 lung epithelia cells. The seeded structures are imaged with confocal microscopy, where spectral imaging with linear unmixing is used to separate auto-fluorescence scaffold contribution from the cell fluorescence. The volume of cellular material present in different sections of the structures is analyzed, to study the influence of structural parameters on cell distribution. Furthermore, time-lapse studies are performed to map the relation between scaffold parameters and cell movement. In the future, this kind of differentiated 3D growth platform, could be applied for optimized culture growth, cell differentiation, and advanced cell therapies