Evaluation of Cannabidiol (CBD) effects on positive symptoms of patients with Schizophrenia in 22 Bahman hospital of Qazvin city in 1399

چکیده زمینه و هدف: اسکیزوفرنی یک اختلال روانپزشکی با دوره های مداوم یا عودکننده روان پریشی میباشد . دارو های آنتی سایکوتیک خط اول درمان اسکیزوفرنی, از طریق آنتاگونیست گیرنده های مرکزی دوپامین هستند. مطالعه ای با هدف بررسی تاثیر کانابیدیول به عنوان داروی کمکی در بیماران اسکیزوفرنی تحت درمان با ریسپریدون بر اساس پرسشنامه ی PANSS و مقایسه با گروه دریافت کننده ی ریسپریدون و پلاسبو در بیمارستان 22 بهمن قزوین سال 1401 انجام دادیم. مواد و روش ها: این مطالعه کارآزمایی بالینی سه سوکور, بر روی 30 بیمار اسکیزوفرنی مراجعه کننده به بیمارستان 22 بهمن قزوین در سال 1401انجام شد. بیماران به دو گروه مداخله با رسپریدون و 150 میلی گرم CBD لیپوزومال در روز یا رسپریدون و دارونما تقسیم شدند. قبل از شروع درمان, دو هفته , 4 هفته و6 هفته بعد از شروع درمان پرسشنامه ی PANSS (positive and negative syndrome score) برای بیماران تکمیل گردید و تغییرات بررسی شد. داده ها با استفاده از نرم افزار SPSS وارد کامپیوتر شد و سطح معنی دار کمتر از 0.05 در نظر گرفته شد. یافته ها: فاکتورهای میانگین نمره ی کل پرسشنامه ی PANSS ، میانگین نمره ی علائم مثبت و میانگین نمره ی علائم جنرال بین دو گروه کانابیدیول و پلاسبو درهفته های 2,4و6 بعد از مداخله تفاوت معناداری وجود دارد و بین میانگین نمره علائم منفی طی روند درمان 6 هفته ای بین 2 گروه تفاوت معناداری وجود ندارد. هم چنین در دو گروه مورد مطالعه تفاوت معناداری از نظر بروز عوارض وجود نداشت. نتیجه گیری: طبق این مطالعه میتوان از کانابیدیول در کنار داروی ریسپریدون به عنوان دارو ی کمکی جهت درمان بیماران اسکیزوفرنی استفاده کرد. بهبود بهتر و سریع تردر گروه دریافت کننده ی کانابیدیول به نفع استفاده از این دارو است. کلمات کلیدی: اسکیزوفرنی_ کانابیدیول_کانابینوئید_ PANSS_سایکوز_CB

Coenzyme Q10 and Its Therapeutic Potencies Against COVID-19 and Other Similar Infections: A Molecular Review

Purpose: New lethal coronavirus disease 2019 (COVID-19), currently, has been converted to a disastrous pandemic worldwide. As there has been found no definitive treatment for the infection in this review we focused on molecular aspects of coenzyme Q10 (CoQ10) and possible therapeutic potencies of CoQ10 against COVID-19 and similar infections. Methods: This is a narrative review in which we used some authentic resources including PubMed, ISI, Scopus, Science Direct, Cochrane, and some preprint databases, the molecular aspects of CoQ10 effects, regarding to the COVID-19 pathogenesis, have been analyzed and discussed. Results: CoQ10 is an essential cofactor in the electron transport chain of the phosphorylative oxidation system. It is a powerful lipophilic antioxidant, anti-apoptotic, immunomodulatory and anti-inflammatory supplement which has been tested for the management and prevention of a variety of diseases particularly diseases with inflammatory pathogenesis. CoQ10 is a strong anti-inflammatory agent which can reduce tumor necrosis factor-α (TNF-α), interleukin (IL)- 6, C-reactive protein (CRP), and other inflammatory cytokines. The cardio-protective role of CoQ10 in improving viral myocarditis and drug induced cardiotoxicity has been determined in different studies. CoQ10 could also improve the interference in the RAS system caused by COVID-19 through exerting anti-Angiotensin II effects and decreasing oxidative stress. CoQ10 passes easily through blood–brain barrier (BBB). As a neuroprotective agent CoQ10 can reduce oxidative stress and modulate the immunologic reactions. These properties may help to reduce CNS inflammation and prevent BBB damage and neuronal apoptosis in COVID-19 patients. Conclusion: CoQ10 supplementation may prevent the COVID-19-induced morbidities with a potential protective role against the deleterious consequences of the disease, further clinical evaluations are encouraged

A family presenting with multiple endocrine neoplasia type 2B: A case report

<p>Abstract</p> <p>Introduction</p> <p>Multiple endocrine neoplasia 2B, a rare autosomal dominant syndrome, is characterized by early onset of medullary thyroid carcinoma, pheochromocytoma, marfanoid habitus and mucosal neuromas of the tongue, lips, inner cheeks and inner eyelids. Gangliomatosis of the gastrointestinal tract and its complications may also occur in patients with this disease.</p> <p>Case presentation</p> <p>We present the case of a 16-year-old Persian man diagnosed as having a non-invasive form of multiple endocrine neoplasia 2B (medullary thyroid cancer, mucosal neuroma of the tongue, lips and inner eyelids). Our patient, who had a positive family history of medullary thyroid cancer, was of normal height with no signs of marfanoid habitus.</p> <p>Conclusions</p> <p>Ophthalmological and oral manifestations of multiple endocrine neoplasia 2B, as in the case of our patient, are rare presentations of the disease; unfortunately in the case of our patient his condition had not been noted and acted upon until he presented to our department. The diagnosis in our patient's case was made only after his mother presented with the same condition. As a result, we emphasize that physicians should pay more attention to the oral and ocular signs of multiple endocrine neoplasia 2B in order to diagnose this fatal syndrome at an earlier phase.</p

knowledge, attitude and practice among mothers of 6-36 months infants in Khoramabad health centers on proper feeding (in 2015)

Background : The most important factors affecting nutritional status of infants and its improvement is mothers&rsquo; knowledge, attitude and practice regarding proper nutrition of their children. This study aimed to assess knowledge, attitude and behavior practice of mothers having children of 6-36 months in health centers of Khorramabad on proper feeding of their children. Materials and Methods: In this cross- sectional descriptive-analytic study , information of 302 mothers of 6-36 months children referred to health centers in Khorramabad were collected thorough maternal health records and interview records , and data were analyzed using&nbsp; SPSS 21 software, chi-square test, Spearman and Pearson correlation coefficient. Results: Based on the findings and obtained scores by mothers, 69.9% of &nbsp;the women had good knowledge,69.9% had good attitude and 64.6% had good practice on proper nutrition for their children. There was a significant relationship between mothers&rsquo; attitude and education, fathers&rsquo; education and mothers&rsquo; occupation. There was a significant relationship between fathers&rsquo; level of practice, job, number of children, and birth order. There was no significant relationship between the attention level to mass media and attitude and knowledge score, but there was a significant correlation with practice. There was no significant relationship between mothers&rsquo; knowledge and education, fathers&rsquo; education, mothers&rsquo; job, fathers&rsquo; job, income, number of children and birth order. Conclusion: According to the results, the level of knowledge, attitude and practice in mothers is in a good level, but due to the potentional role of father in mother,s practice, it seems that a family based educational programs in health centers, hospitals and mass media is necessary

Penetration of Different Liquids in Wood-Based Composites: The Effect of Adsorption Energy

The penetration properties of three different liquids on the surface of medium-density fiberboard (MDF) and particleboard panels were studied. Water, as a polar liquid, was compared to two other less polar liquids (namely, ethanol and kerosene) with significantly larger molecules. Measurement of penetration time and wetted area demonstrated significantly higher values for water in comparison with the other two liquids, in both composite types. Calculation of adsorption energies, as well as adsorption distances, of the three liquid molecules on hemicellulose showed higher potentiality of water molecules in forming bonds on hemicellulose. However, comparison of the adsorption energies of cellulose with hemicellulose indicated a higher impact of the formation of bonds between hydroxyl groups in water and cellulose in hindering the penetration of water molecules into the composite textures. It was concluded that the formation of strong and stable bonds between the hydroxyl groups in water and cellulose resulted in a significant increase in penetration time and wetted area