Orthogonal symmetries and Clifford algebras

Involutions of the Clifford algebra of a quadratic space induced by orthogonal symmetries are investigated.Comment: 22 page

On split products of quaternion algebras with involution in characteristic two

The question of whether a split tensor product of quaternion algebras with involution over a field of characteristic two can be expressed as a tensor product of split quaternion algebras with involution, is shown to have an affirmative answer

QCD Corrections in two-Higgs-doublet extensions of the Standard Model with Minimal Flavor Violation

We present the QCD corrections to R_b and to the Delta B=1 effective Hamiltonian in models with a second Higgs field that couples to the quarks respecting the criterion of Minimal Flavor Violation, thus belonging either to the (1,2)_1/2 or to the (8,2)_1/2 representation of SU(3)xSU(2)xU(1). After the inclusion of the QCD corrections, the prediction for R_b becomes practically insensitive to the choice of renormalization scheme for the top mass, which for the type-I and type-II models translates in a more robust lower bound on tan(beta). The QCD-corrected determinations of Rb and BR(B->Xs gamma) are used to discuss the constraints on the couplings of a (colored) charged Higgs boson to top and bottom quarks.Comment: 19 pages, 7 figures. v2: version published in Phys. Rev. D, with additional reference and not

Nanoparticles-cell association predicted by protein corona fingerprints

In a physiological environment (e.g., blood and interstitial fluids) nanoparticles (NPs) will bind proteins shaping a "protein corona" layer. The long-lived protein layer tightly bound to the NP surface is referred to as the hard corona (HC) and encodes information that controls NP bioactivity (e.g. cellular association, cellular signaling pathways, biodistribution, and toxicity). Decrypting this complex code has become a priority to predict the NP biological outcomes. Here, we use a library of 16 lipid NPs of varying size (Ø ≈ 100-250 nm) and surface chemistry (unmodified and PEGylated) to investigate the relationships between NP physicochemical properties (nanoparticle size, aggregation state and surface charge), protein corona fingerprints (PCFs), and NP-cell association. We found out that none of the NPs' physicochemical properties alone was exclusively able to account for association with human cervical cancer cell line (HeLa). For the entire library of NPs, a total of 436 distinct serum proteins were detected. We developed a predictive-validation modeling that provides a means of assessing the relative significance of the identified corona proteins. Interestingly, a minor fraction of the HC, which consists of only 8 PCFs were identified as main promoters of NP association with HeLa cells. Remarkably, identified PCFs have several receptors with high level of expression on the plasma membrane of HeLa cells

Nanoparticles-cell association predicted by protein corona fingerprints

In a physiological environment (e.g., blood and interstitial fluids) nanoparticles (NPs) will bind proteins shaping a "protein corona" layer. The long-lived protein layer tightly bound to the NP surface is referred to as the hard corona (HC) and encodes information that controls NP bioactivity (e.g. cellular association, cellular signaling pathways, biodistribution, and toxicity). Decrypting this complex code has become a priority to predict the NP biological outcomes. Here, we use a library of 16 lipid NPs of varying size (Ø ≈ 100-250 nm) and surface chemistry (unmodified and PEGylated) to investigate the relationships between NP physicochemical properties (nanoparticle size, aggregation state and surface charge), protein corona fingerprints (PCFs), and NP-cell association. We found out that none of the NPs' physicochemical properties alone was exclusively able to account for association with human cervical cancer cell line (HeLa). For the entire library of NPs, a total of 436 distinct serum proteins were detected. We developed a predictive-validation modeling that provides a means of assessing the relative significance of the identified corona proteins. Interestingly, a minor fraction of the HC, which consists of only 8 PCFs were identified as main promoters of NP association with HeLa cells. Remarkably, identified PCFs have several receptors with high level of expression on the plasma membrane of HeLa cells

A compact representation of the 2 photon 3 gluon amplitude

A compact representation of the loop amplitude gamma gamma ggg -> 0 is presented. The result has been obtained by using helicity methods and sorting with respect to an irreducible function basis. We show how to convert spinor representations into a field strength representation of the amplitude. The amplitude defines a background contribution for Higgs boson searches at the LHC in the channel H -> gamma gamma + jet which was earlier extracted indirectly from the one-loop representation of the 5-gluon amplitude.Comment: 15 pages Latex, 6 eps files included, revised versio