2 research outputs found
Gold(I) Catalysis Applied to the Stereoselective Synthesis of Indeno[2,1-b]thiochromene Derivatives and Seleno Analogues
A gold(I)-catalyzed cascade reaction for the stereoselective
synthesis of sulfur- or selenium-containing indeno[1,2-b]chromene
derivatives from o-(alkynyl)styrenes substituted at the triple bond with a
thio- or seleno-aryl group is described. The reaction involves a double
cyclization process through a proposed key gold−cyclopropyl carbene
intermediate that evolves by the intramolecular addition of an aromatic to
the cyclopropane ring, affording polycyclic structures. The enantioselective
version was studied using gold(I) complexes bearing chiral ligands.We gratefully acknowledge MICINN (PID2020-115789GBC21), “NextGenerationEU/PRTR” (PDC2021-120825-C21), Junta de Castilla y León, and FEDER (BU049P20) for financial support. The project leading to these results also received funding from the “la Caixa” Foundation, under Agreement LCF/PR/PR18/51130007 (CAIXA-UBU001). C.V. and S.S.-P. thank Junta de Castilla y León (Consejería de Educación) and Fondo Social Europeo for postdoctoral contracts