4 research outputs found
Fourth-Order Perturbation Theory for the Half-Filled Hubbard Model in Infinite Dimensions
We calculate the zero-temperature self-energy to fourth-order perturbation
theory in the Hubbard interaction for the half-filled Hubbard model in
infinite dimensions. For the Bethe lattice with bare bandwidth , we compare
our perturbative results for the self-energy, the single-particle density of
states, and the momentum distribution to those from approximate analytical and
numerical studies of the model. Results for the density of states from
perturbation theory at agree very well with those from the Dynamical
Mean-Field Theory treated with the Fixed-Energy Exact Diagonalization and with
the Dynamical Density-Matrix Renormalization Group. In contrast, our results
reveal the limited resolution of the Numerical Renormalization Group approach
in treating the Hubbard bands. The momentum distributions from all approximate
studies of the model are very similar in the regime where perturbation theory
is applicable, . Iterated Perturbation Theory overestimates the
quasiparticle weight above such moderate interaction strengths.Comment: 19 pages, 17 figures, submitted to EPJ
Stoerungstheorie in vierter Ordnung fuer das halbgefuellte Hubbard-Modell im Limes hoher Dimensionen
Wir haben die T=0 Selbstenergie stoerungstheoretisch bis einschliesslich vierte Ordnung in der Hubbard-Wechselwirkung U fuer das halbgefuellte Hubbard-Modell im Limes hoher Dimensionen berechnet.
Unsere Ergebnisse fuer die Selbstenergie, die Zustandsdichte und die Impulsverteilung werden mit den Ergebnissen diverser Naeherungsmethoden (FE-ED, DDMRG, NRG, IPT, RDA) fuer das Hubbard-Modell verglichen
Stoerungstheorie in vierter Ordnung fuer das halbgefuellte Hubbard-Modell im Limes hoher Dimensionen
Wir haben die T=0 Selbstenergie stoerungstheoretisch bis einschliesslich vierte Ordnung in der Hubbard-Wechselwirkung U fuer das halbgefuellte Hubbard-Modell im Limes hoher Dimensionen berechnet.
Unsere Ergebnisse fuer die Selbstenergie, die Zustandsdichte und die Impulsverteilung werden mit den Ergebnissen diverser Naeherungsmethoden (FE-ED, DDMRG, NRG, IPT, RDA) fuer das Hubbard-Modell verglichen
IL3RA-Targeting Antibody–Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies
IL3RA (CD123) is the alpha subunit of the interleukin 3 (IL-3) receptor, which regulates the proliferation, survival, and differentiation of hematopoietic cells. IL3RA is frequently expressed in acute myeloid leukemia (AML) and classical Hodgkin lymphoma (HL), presenting an opportunity to treat AML and HL with an IL3RA-directed antibody–drug conjugate (ADC). Here, we describe BAY-943 (IL3RA-ADC), a novel IL3RA-targeting ADC consisting of a humanized anti-IL3RA antibody conjugated to a potent proprietary kinesin spindle protein inhibitor (KSPi). In vitro, IL3RA-ADC showed potent and selective antiproliferative efficacy in a panel of IL3RA-expressing AML and HL cell lines. In vivo, IL3RA-ADC improved survival and reduced tumor burden in IL3RA-positive human AML cell line-derived (MOLM-13 and MV-4-11) as well as in patient-derived xenograft (PDX) models (AM7577 and AML11655) in mice. Furthermore, IL3RA-ADC induced complete tumor remission in 12 out of 13 mice in an IL3RA-positive HL cell line-derived xenograft model (HDLM-2). IL3RA-ADC was well-tolerated and showed no signs of thrombocytopenia, neutropenia, or liver toxicity in rats, or in cynomolgus monkeys when dosed up to 20 mg/kg. Overall, the preclinical results support the further development of BAY-943 as an innovative approach for the treatment of IL3RA-positive hematologic malignancies