Fourth-Order Perturbation Theory for the Half-Filled Hubbard Model in Infinite Dimensions

We calculate the zero-temperature self-energy to fourth-order perturbation theory in the Hubbard interaction $U$ for the half-filled Hubbard model in infinite dimensions. For the Bethe lattice with bare bandwidth $W$, we compare our perturbative results for the self-energy, the single-particle density of states, and the momentum distribution to those from approximate analytical and numerical studies of the model. Results for the density of states from perturbation theory at $U/W=0.4$ agree very well with those from the Dynamical Mean-Field Theory treated with the Fixed-Energy Exact Diagonalization and with the Dynamical Density-Matrix Renormalization Group. In contrast, our results reveal the limited resolution of the Numerical Renormalization Group approach in treating the Hubbard bands. The momentum distributions from all approximate studies of the model are very similar in the regime where perturbation theory is applicable, $U/W \le 0.6$. Iterated Perturbation Theory overestimates the quasiparticle weight above such moderate interaction strengths.Comment: 19 pages, 17 figures, submitted to EPJ

Stoerungstheorie in vierter Ordnung fuer das halbgefuellte Hubbard-Modell im Limes hoher Dimensionen

Wir haben die T=0 Selbstenergie stoerungstheoretisch bis einschliesslich vierte Ordnung in der Hubbard-Wechselwirkung U fuer das halbgefuellte Hubbard-Modell im Limes hoher Dimensionen berechnet. Unsere Ergebnisse fuer die Selbstenergie, die Zustandsdichte und die Impulsverteilung werden mit den Ergebnissen diverser Naeherungsmethoden (FE-ED, DDMRG, NRG, IPT, RDA) fuer das Hubbard-Modell verglichen

Stoerungstheorie in vierter Ordnung fuer das halbgefuellte Hubbard-Modell im Limes hoher Dimensionen

Wir haben die T=0 Selbstenergie stoerungstheoretisch bis einschliesslich vierte Ordnung in der Hubbard-Wechselwirkung U fuer das halbgefuellte Hubbard-Modell im Limes hoher Dimensionen berechnet. Unsere Ergebnisse fuer die Selbstenergie, die Zustandsdichte und die Impulsverteilung werden mit den Ergebnissen diverser Naeherungsmethoden (FE-ED, DDMRG, NRG, IPT, RDA) fuer das Hubbard-Modell verglichen

IL3RA-Targeting Antibody–Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies

IL3RA (CD123) is the alpha subunit of the interleukin 3 (IL-3) receptor, which regulates the proliferation, survival, and differentiation of hematopoietic cells. IL3RA is frequently expressed in acute myeloid leukemia (AML) and classical Hodgkin lymphoma (HL), presenting an opportunity to treat AML and HL with an IL3RA-directed antibody–drug conjugate (ADC). Here, we describe BAY-943 (IL3RA-ADC), a novel IL3RA-targeting ADC consisting of a humanized anti-IL3RA antibody conjugated to a potent proprietary kinesin spindle protein inhibitor (KSPi). In vitro, IL3RA-ADC showed potent and selective antiproliferative efficacy in a panel of IL3RA-expressing AML and HL cell lines. In vivo, IL3RA-ADC improved survival and reduced tumor burden in IL3RA-positive human AML cell line-derived (MOLM-13 and MV-4-11) as well as in patient-derived xenograft (PDX) models (AM7577 and AML11655) in mice. Furthermore, IL3RA-ADC induced complete tumor remission in 12 out of 13 mice in an IL3RA-positive HL cell line-derived xenograft model (HDLM-2). IL3RA-ADC was well-tolerated and showed no signs of thrombocytopenia, neutropenia, or liver toxicity in rats, or in cynomolgus monkeys when dosed up to 20 mg/kg. Overall, the preclinical results support the further development of BAY-943 as an innovative approach for the treatment of IL3RA-positive hematologic malignancies