Russian intervention in Syria : exploring the nexus between regime consolidation and energy transnationalisation

Interpretations of Russia’s military intervention in Syria overwhelmingly focus on Russia’s political motivations. An alternative view foregrounds Russia’s economic motivations, namely, the construction of a multi-billion-dollar gas pipeline traversing Iran, Iraq and Syria. This article examines the salience of Russia’s economic motivations and considers two related aspects: First, if Russian intervention aims to secure areas of strategic importance for the proposed pipeline. Second, if Russian intervention realises longer term political and commercial interests that include proposed future pipeline projects. The evidence suggests Russian military policies towards Syria are unlikely to be motivated primarily by the prospect of a proposed gas pipeline, but that regime consolidation is a more immediate policy goal. This article then posits that Russian intervention has a distinct ‘dual logic’ aimed at integrating the interests of key regional actors into a transnational energy network, while stabilising Russia’s regional dominance within this network

A precarious peace? The threat of paramilitary violence to the peace process in Colombia

This article provides an investigation into claims that paramilitary violence in Colombia can pose a threat to the peace agreement signed in 2016 between the Colombian government and the FARC rebels. These claims highlight the capacity for paramilitary groups to ‘spoil’ the peace deal. Hitherto, however, there is a lack of scholarly research to investigate the potential of paramilitary spoiling. Firstly, this article highlights the flaws in the government’s perspective that paramilitarism no longer exists in Colombia. Instead, the government argues that Colombia is plagued by criminal bands (known as BACRIMs). Secondly, through fieldwork interviews and questionnaires conducted in FARC demobilisation camps, together with descriptive data analysed through a uniquely coded dataset on violence in western Colombia, this article supports claims that successor paramilitary groups represent a key spoiler threat to the current government-FARC peace process. On the one hand, the paramilitaries can represent a direct spoiler threat by, for instance, violently targeting demobilising FARC guerrillas. On the other hand, successor paramilitary groups represent a key indirect spoiler threat, as paramilitary violence is exacerbating the root causes of the conflict that the peace deal seeks to address, with negative implications for the prospects for peace

Rooted in violence: civil war, international trade and the expansion of palm oil in Colombia

Internal armed conflict severely inhibits economic growth according to a prominent set of civil war literature. Similarly, emerging scholarship finds that civil war inhibits processes of economic globalisation which are argued to produce economic growth. A case in point is international trade, which is reportedly stymied by intra-state war. In contrast, this article employs a critical theoretical framework which acknowledges the often violent tendencies of globalised capitalism. By analysing Colombia’s palm oil industry, this article argues that civil war violence can facilitate international trade. In the case study which is presented, violence perpetrated by Colombia’s public armed forces and right-wing paramilitaries has enabled the palm oil sector to enter and compete in the globalised economy. This includes processes of forced displacement, which have acquired land for palm oil cultivation, and violence directed at civil groups deemed inimical to the interests of the palm oil sector. By employing a micro-level approach, this article attempts to isolate violent trends related to palm oil cultivation in Meta, the largest African palm growing region in Colombia. An attempt is therefore made to give an empirically informed account of how violence in Colombia’s civil war is facilitating palm oil exports

Investigating the “curious” case of civil war and foreign direct investment: evidence from Sudan

It is typically argued that civil war acutely inhibits inward flows of foreign direct investment (FDI). However, the evidence is inconsistent and does not support the assumed negative relationship between civil war and FDI. Some studies suggest that FDI enters countries with internal armed conflicts unabated; others show that civil war economies exhibit strong increases in FDI during conflict. Underpinned by a liberal interpretation of war, this scholarship finds these trends to be surprising, counter-intuitive and curious, arguing that FDI enters conflict zones in spite of violence. In contrast, critical perspectives can provide insights by acknowledging that violence can facilitate economic processes such as FDI, creating a particular form of security and stability that can be conducive to FDI inflows. This article examines the Second Sudanese Civil War (1983-2005), a country which exhibited strong increases in FDI during phases of the conflict. It is argued that particular types of violence perpetrated by the government’s armed forces and pro-government militias – groups which were sympathetic to the interests of key investors in the oil industry – facilitated FDI in Sudan’s oil sector during the 2000s to the detriment of large sections of the civilian population affected by the violence

COngenital heart disease and the Diagnostic yield with Exome sequencing (CODE Study): prospective cohort study and systematic review

OBJECTIVES: To determine the yield of antenatal exome sequencing (ES) over chromosome microarray (CMA) / conventional karyotyping in; (i) any prenatally diagnosed congenital heart disease (CHD); (ii) isolated CHD; (iii) multi‐system CHD and; (iv) CHD by phenotypic subgroup. / METHODS: A prospective cohort study of 197 trios undergoing ES following CMA/karyotype because CHD was identified prenatally and a systematic review of the literature was performed. MEDLINE, EMBASE and CINAHL (2000–Oct 2019) databases were searched electronically. Selected studies included those with; (i) >3 cases; (ii) initiation of testing based upon a prenatal phenotype only and; (iii) where CMA/karyotyping was negative. PROSPERO No. CRD42019140309. / RESULTS: In our cohort ES gave an additional diagnostic yield in; (i) all CHD; (ii) isolated CHD and; (iii) multi‐system CHD of 12.7% (n=25/197), 11.5% (n=14/122) and 14.7% (n=11/75) (p=0.81). The pooled incremental yields for the aforementioned categories from 18‐studies (n=636) were 21% (95% CI, 15‐27%), 11% (95% CI, 7‐15%) and 37% (95% CI, 18%‐56%) respectively. This did not differ significantly when sub‐analyses were limited to studies including >20 cases. In instances of multi‐system CHD in the primary analysis, the commonest extra‐cardiac anomalies associated with a pathogenic variant were those affecting the genitourinary system 44.2% (n=23/52). Cardiac shunt lesions had the greatest incremental yield, 41% (95% CI, 19‐63%), followed by right‐sided lesions 26% (95% CI, 9‐43%). In the majority of instances pathogenic variants occurred de novo and in autosomal dominant (monoallelic) disease genes (68/96; 70.8%). The commonest monogenic syndrome identified was Kabuki syndrome (n=19/96; 19.8%). / CONCLUSIONS: Despite the apparent incremental yield of prenatal exome sequencing in congenital heart disease, the routine application of such a policy would require the adoption of robust bioinformatic, clinical and ethical pathways. Whilst the greatest yield is with multi‐system anomalies, consideration may also be given to performing ES in the presence of isolated cardiac abnormalities

Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis

Fibroblasts derived from the lungs of patients with idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc) produce low levels of prostaglandin (PG) E(2), due to a limited capacity to up-regulate cyclooxygenase-2 (COX-2). This deficiency contributes functionally to the fibroproliferative state, however the mechanisms responsible are incompletely understood. In the present study, we examined whether the reduced level of COX-2 mRNA expression observed in fibrotic lung fibroblasts is regulated epigenetically. The DNA methylation inhibitor, 5-aza-2′-deoxycytidine (5AZA) restored COX-2 mRNA expression by fibrotic lung fibroblasts dose dependently. Functionally, this resulted in normalization of fibroblast phenotype in terms of PGE(2) production, collagen mRNA expression and sensitivity to apoptosis. COX-2 methylation assessed by bisulfite sequencing and methylation microarrays was not different in fibrotic fibroblasts compared with controls. However, further analysis of the methylation array data identified a transcriptional regulator, chromosome 8 open reading frame 4 (thyroid cancer protein 1, TC-1) (c8orf4), which is hypermethylated and down-regulated in fibrotic fibroblasts compared with controls. siRNA knockdown of c8orf4 in control fibroblasts down-regulated COX-2 and PGE(2) production generating a phenotype similar to that observed in fibrotic lung fibroblasts. Chromatin immunoprecipitation demonstrated that c8orf4 regulates COX-2 expression in lung fibroblasts through binding of the proximal promoter. We conclude that the decreased capacity of fibrotic lung fibroblasts to up-regulate COX-2 expression and COX-2-derived PGE(2) synthesis is due to an indirect epigenetic mechanism involving hypermethylation of the transcriptional regulator, c8orf4

24-h severe energy restriction impairs postprandial glycaemic control in young, lean males

Intermittent energy restriction (IER) involves short periods of severe energy restriction interspersed with periods of adequate energy intake, and can induce weight loss. Insulin sensitivity is impaired by short-term, complete energy restriction, but the effects of IER are not well known. In randomised order, fourteen lean men (age: 25 (sd 4) years; BMI: 24 (sd 2) kg/m2; body fat: 17 (4) %) consumed 24-h diets providing 100 % (10 441 (sd 812) kJ; energy balance (EB)) or 25 % (2622 (sd 204) kJ; energy restriction (ER)) of estimated energy requirements, followed by an oral glucose tolerance test (OGTT; 75 g of glucose drink) after fasting overnight. Plasma/serum glucose, insulin, NEFA, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP) and fibroblast growth factor 21 (FGF21) were assessed before and after (0 h) each 24-h dietary intervention, and throughout the 2-h OGTT. Homoeostatic model assessment of insulin resistance (HOMA2-IR) assessed the fasted response and incremental AUC (iAUC) or total AUC (tAUC) were calculated during the OGTT. At 0 h, HOMA2-IR was 23 % lower after ER compared with EB (P<0·05). During the OGTT, serum glucose iAUC (P<0·001), serum insulin iAUC (P<0·05) and plasma NEFA tAUC (P<0·01) were greater during ER, but GLP-1 (P=0·161), GIP (P=0·473) and FGF21 (P=0·497) tAUC were similar between trials. These results demonstrate that severe energy restriction acutely impairs postprandial glycaemic control in lean men, despite reducing HOMA2-IR. Chronic intervention studies are required to elucidate the long-term effects of IER on indices of insulin sensitivity, particularly in the absence of weight loss

Fetal exome sequencing for isolated increased nuchal translucency: should we be doing it?

Objective: To evaluate the utility of prenatal exome sequencing (ES) for isolated increased nuchal translucency (NT) and investigate factors which increase diagnostic yield. Design: Retrospective analysis of data from two prospective cohort studies. Setting: Fetal medicine centres in the UK and USA. Population: Fetuses with increased NT ≥3.5mm at 11-14 weeks’ gestation recruited to the Prenatal Assessment of Genomes and Exomes (PAGE) and Columbia fetal WES studies (n = 213). Methods: We grouped cases based on (i) the presence of additional structural abnormalities at presentation in the first trimester or later in pregnancy, and (ii) NT measurement at presentation. We compared diagnostic rates between groups using Fisher exact test. Main Outcome Measures: Detection of diagnostic genetic variants considered to have caused the observed fetal structural anomaly. Results: Diagnostic variants were detected in 12 (22.2%) of 54 fetuses presenting with non-isolated increased NT, 12 (32.4%) of 37 fetuses with isolated increased NT in the first trimester and additional abnormalities later in pregnancy, and 2 (1.8%) of 111 fetuses with isolated increased NT in the first trimester and no other abnormalities on subsequent scans. Diagnostic rate also increased with increasing size of NT. Conclusions: The diagnostic yield of prenatal ES is low for fetuses with isolated increased NT but significantly higher where there are additional structural anomalies. Prenatal ES may not be appropriate for truly isolated increased NT but timely, careful ultrasound scanning to identify other anomalies emerging later can direct testing to focus where there is a higher likelihood of diagnosis