Novelty and Diversity in Retrieval Evaluation

Queries submitted to search engines rarely provide a complete and precise description of a user's information need. Most queries are ambiguous to some extent, having multiple interpretations. For example, the seemingly unambiguous query ``tennis lessons'' might be submitted by a user interested in attending classes in her neighborhood, seeking lessons for her child, looking for online videos lessons, or planning to start a business teaching tennis. Search engines face the challenging task of satisfying different groups of users having diverse information needs associated with a given query. One solution is to optimize ranking functions to satisfy diverse sets of information needs. Unfortunately, existing evaluation frameworks do not support such optimization. Instead, ranking functions are rewarded for satisfying the most likely intent associated with a given query. In this thesis, we propose a framework and associated evaluation metrics that are capable of optimizing ranking functions to satisfy diverse information needs. Our proposed measures explicitly reward those ranking functions capable of presenting the user with information that is novel with respect to previously viewed documents. Our measures reflects quality of a ranking function by taking into account its ability to satisfy diverse users submitting a query. Moreover, the task of identifying and establishing test frameworks to compare ranking functions on a web-scale can be tedious. One reason for this problem is the dynamic nature of the web, where documents are constantly added and updated, making it necessary for search engine developers to seek additional human assessments. Along with issues of novelty and diversity, we explore one approximate approach to compare different ranking functions by overcoming the problem of lacking complete human assessments. We demonstrate that our approach is capable of accurately sorting ranking functions based on their capability of satisfying diverse users, even in the face of incomplete human assessments

Comparative Analysis of Image Enhancement Techniques for Ultrasound Liver Image

Liver cancer is the sixth most common malignant tumour in the world and the third most common cause of cancer-related deaths worldwide. To diagnose such liver diseases, In this paper comparison has been made for various image enhancement techniques that are applied to liver ultrasound image. Three types of liver ultrasound images used are normal, benign and malignant liver images. The techniques, which are compared on the basis of two evaluation parameters Peak Signal to Noise Ratio (PSNR) and Mean Square Error (MSE) including, Contrast Stretching, Shock Filter, Histogram Equalization, Contrast Limited Adaptive Histogram Equalization (CLAHE).Such a comparison would be helpful in determining the best suited method for clinical diagnosis. It also has been observed that the Shock filter gives the better performance than others for liver ultrasonic image analysis.DOI:http://dx.doi.org/10.11591/ijece.v2i6.151

Raman Spectroscopic Methods for Classification of Normal and Malignant Hypopharyngeal Tissues: An Exploratory Study

Laryngeal cancer is more common in males. The present study is aimed at exploration of potential of conventional Raman spectroscopy in classifying normal from a malignant laryngopharyngeal tissue. We have recorded Raman spectra of twenty tissues (aryepiglottic fold) using an in-house built Raman setup. The spectral features of mean malignant spectrum suggests abundance proteins whereas spectral features of mean normal spectrum indicate redundancy of lipids. PCA was employed as discriminating algorithm. Both, unsupervised and supervised modes of analysis as well as match/mismatch “limit test” methodology yielded clear classification among tissue types. The findings of this study demonstrate the efficacy of conventional Raman spectroscopy in classification of normal and malignant laryngopharyngeal tissues. A rigorous evaluation of the models with development of suitable fibreoptic probe may enable real-time Raman spectroscopic diagnosis of laryngopharyngeal cancers in future

Genetic diversity among Arachis species based on RAPDs

Thirty-two accessions of wild species of Arachis belonging to twenty-five species and grouped under six sections were used to study genetic relationship using RAPOs. Twenty-nine primers belonging to OPH 1–20 and and OPM 1–9 were used in the study. All the primers showed polymorphic bands and the number of bands varied from five to thirty-three. Similarity values (Sij) for 464 pairwise comparisons among 32 accessions ranged from a minimum of 0 to a maximum of 49%, with an average of 15%. The data obtained from cluster analysis matched that obtained from multidimensional scaling (MDS). Cultivated species A. hypogaea grouped with A. monticola, a tetraploid wild species and a probable progenator of A. hypogaea. A. stenosperma accessions grouped together. Wild species from section Arachis with B genome formed two clusters, with one cluster having A. batizocoi showing distant relationship than the other cluster with A. hoehnei showing closer relationship. A. glandulifera having the 0 genome remained apart. It was possible to explain the grouping of wild species grouped as per their relationship with each other. The exception was the two accessions of A. cardenasii (ICG 11558 and 11559) from section Arachis. They did not group with any of the A, B or the D genome species from section Arachis nor with each other

Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus

The association of WW domain-containing oxidoreductase WWOX gene loss of function with central nervous system (CNS) related pathologies is well documented. These include spinocerebellar ataxia, epilepsy and mental retardation (SCAR12, OMIM: 614322) and early infantile epileptic encephalopathy (EIEE28, OMIM: 616211) syndromes. However, there is complete lack of understanding of the pathophysiological mechanisms at play. In this study, using a Wwox knockout (Wwox KO) mouse model (2 weeks old, both sexes) and stereological studies we observe that Wwox deletion leads to a significant reduction in the number of hippocampal GABA-ergic (γ-aminobutyric acid) interneurons. Wwox KO mice displayed significantly reduced numbers of calcium-binding protein parvalbumin (PV) and neuropeptide Y (NPY) expressing interneurons in different subfields of the hippocampus in comparison to Wwox wild-type (WT) mice. We also detected decreased levels of Glutamic Acid Decarboxylase protein isoforms GAD65/67 expression in Wwox null hippocampi suggesting lower levels of GABA synthesis. In addition, Wwox deficiency was associated with signs of neuroinflammation such as evidence of activated microglia, astrogliosis, and overexpression of inflammatory cytokines Tnf-a and Il6. We also performed comparative transcriptome-wide expression analyses of neural stem cells grown as neurospheres from hippocampi of Wwox KO and WT mice thus identifying 283 genes significantly dysregulated in their expression. Functional annotation of transcriptome profiling differences identified ?neurological disease? and ?CNS development related functions? to be significantly enriched. Several epilepsy-related genes were found differentially expressed in Wwox KO neurospheres. This study provides the first genotype-phenotype observations as well as potential mechanistic clues associated with Wwox loss of function in the brain.Fil: Hussain, Tabish. University of Texas Health Science Center at Houston. University of Texas Md Anderson Cancer Center; Estados UnidosFil: Kil, Hyunsuk. University of Texas Health Science Center at Houston. University of Texas Md Anderson Cancer Center; Estados UnidosFil: Hattiangady, Bharathi. Texas A&M Health Science Center College of Medicine; Estados UnidosFil: Lee, Jaeho. University of Texas Health Science Center at Houston. University of Texas Md Anderson Cancer Center; Estados UnidosFil: Kodali, Maheedhar. Texas A&M Health Science Center College of Medicine; Estados UnidosFil: Shuai, Bing. Texas A&M Health Science Center College of Medicine; Estados UnidosFil: Attaluri, Sahithi. Texas A&M Health Science Center College of Medicine; Estados UnidosFil: Takata, Yoko. University of Texas Health Science Center at Houston. University of Texas Md Anderson Cancer Center; Estados UnidosFil: Shen, Jianjun. University of Texas Health Science Center at Houston. University of Texas Md Anderson Cancer Center; Estados UnidosFil: Abba, Martín Carlos. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Shetty, Ashok K.. Texas A&M Health Science Center College of Medicine; Estados UnidosFil: Aldaz, Claudio Marcelo. University of Texas Health Science Center at Houston. University of Texas Md Anderson Cancer Center; Estados Unido

Resveratrol Prevents Age-Related Memory and Mood Dysfunction with Increased Hippocampal Neurogenesis and Microvasculature, and Reduced Glial Activation

Greatly waned neurogenesis, diminished microvasculature, astrocyte hypertrophy and activated microglia are among the most conspicuous structural changes in the aged hippocampus. Because these alterations can contribute to age-related memory and mood impairments, strategies efficacious for mitigating these changes may preserve cognitive and mood function in old age. Resveratrol, a phytoalexin found in the skin of red grapes having angiogenic and antiinflammatory properties, appears ideal for easing these age-related changes. Hence, we examined the efficacy of resveratrol for counteracting age-related memory and mood impairments and the associated detrimental changes in the hippocampus. Two groups of male F344 rats in late middle-age having similar learning and memory abilities were chosen and treated with resveratrol or vehicle for four weeks. Analyses at ~25 months of age uncovered improved learning, memory and mood function in resveratrol-treated animals but impairments in vehicle-treated animals. Resveratrol-treated animals also displayed increased net neurogenesis and microvasculature, and diminished astrocyte hypertrophy and microglial activation in the hippocampus. These results provide novel evidence that resveratrol treatment in late middle age is efficacious for improving memory and mood function in old age. Modulation of the hippocampus plasticity and suppression of chronic low-level inflammation appear to underlie the functional benefits mediated by resveratrol

TMVis: Visualizing Webpage Changes Over Time

TMVis is a web service to provide visualizations of how individual webpages have changed over time. We leverage past research on summarizing collections of webpages with thumbnail-sized screenshots and on choosing a small number of representative archived webpages from a large collection. We offer four visualizations: Image Grid, Image Slider, Timeline, and Animated GIF. Embed codes for the Image Grid and Image Slider can be produced to include these visualizations on separate webpages. This tool can be used to allow scholars from various disciplines, as well as the general public, to explore the temporal nature of webpages

Detecting Agitation Onset in Individuals With Dementia Using Smart Phone Sensors

Individuals living with dementia (ILWD) often experience problematic agitated behaviors, this occurs in up to 80% of ILWD. These behaviors lead to stress for caregivers and increased frequency of institutionalization. There are many proven methods to intervene during agitated behavior outburst and the earlier these methods are used the better the results. Technology has been used successfully to monitor many aspects of health monitoring for older adults. Technology is now being investigated to evaluate the effectiveness of predicting the onset of problem behaviors, especially escalating agitation in ILWD. Off the shelf technology, smart watches and android phones, are being tested to measure limb movements, vocalizations, heart rate and location in facility, to evaluate their ability to provide data that is helpful in predicting agitated behaviors about to occur. This project is a collaboration between nursing and computer science in a major university setting. Currently, work has been completed on volunteers acting as patients to evaluate the ability of this technology to measure the desired parameters. Positive results have been obtained; the goal is to trial this technology on ILWD that have documented history of agitation in an assisted living environment