Association of chronophysiological and psychological risk factors among patients with acute coronary syndromes

Introduction. Coronary risk factors (CRF) and acute coronary syndromes are decreasing in developed countries but have become a major health problem in most middle-income countries. The increased risk of acute coronary syndromes (ACS) in South Asians is not accounted for by conventional risk factors alone. This study examines the association of chronobehavioral risk factors with ACS. Subjects and Methods. We used a case-control study design including 435 patients with ACS who were compared with 495 age- and gender-matched control subjects. Clinical, electrocardiographic, radiological and laboratory data were obtained in all the patients for confirmation of diagnosis by WHO and AHA criteria. Chronobiological and psychological risk factors were assessed by validated questionnaires. Psychological risk factors, such as psychosocial stress, was assessed by stress at work and at home, financial stress, and major life events in the past year. Other questions assessed locus of control and presence of depression. Multivariate logistic regression analysis was conducted after adjustment of age, gender, and body mass index (BMI) to determine the association of risk factors with ACS. Results. Risk factors: all psychological risk factors (40.0% vs. 12.7%, n = 174 vs. 63, P 40°C) (males: 1.14 [1.05-1.23]; females: 1.11 [1.02-1.19]) with ACS was also found. Conclusions. This study shows that psychological risk factors, sleep deprivation, and chronobiological risk factors (late-night eating, large meals, hot and cold weather) were significant risk factors of ACS. © 2017 Nova Science Publishers, Inc

Association of chronophysiological and psychological risk factors among patients with acute coronary syndromes

Introduction. Coronary risk factors (CRF) and acute coronary syndromes are decreasing in developed countries but have become a major health problem in most middle-income countries. The increased risk of acute coronary syndromes (ACS) in South Asians is not accounted for by conventional risk factors alone. This study examines the association of chronobehavioral risk factors with ACS. Subjects and Methods. We used a case-control study design including 435 patients with ACS who were compared with 495 age- and gender-matched control subjects. Clinical, electrocardiographic, radiological and laboratory data were obtained in all the patients for confirmation of diagnosis by WHO and AHA criteria. Chronobiological and psychological risk factors were assessed by validated questionnaires. Psychological risk factors, such as psychosocial stress, was assessed by stress at work and at home, financial stress, and major life events in the past year. Other questions assessed locus of control and presence of depression. Multivariate logistic regression analysis was conducted after adjustment of age, gender, and body mass index (BMI) to determine the association of risk factors with ACS. Results. Risk factors: all psychological risk factors (40.0% vs. 12.7%, n = 174 vs. 63, P 40°C) (males: 1.14 [1.05-1.23]; females: 1.11 [1.02-1.19]) with ACS was also found. Conclusions. This study shows that psychological risk factors, sleep deprivation, and chronobiological risk factors (late-night eating, large meals, hot and cold weather) were significant risk factors of ACS. © 2017 Nova Science Publishers, Inc