Comparison of the Lunar Prodigy and Stratos DR dual-energy X-ray absorptiometers to assess regional bone mineral density

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The effect of excessive fat tissue on the measure of bone mineral density by dual‐X ray absorptiometry: the impact of substantial weight loss following sleeve gastrectomy

International audiencePurpose: Dual‐energy X‐ray absorptiometry (DXA ) is used in clinical routine to determine areal bone mineral density (aBMD ). However, it is not clear whether excessive fat mass or substantial weight loss modify the aBMD measurements. The aim of this study was to evaluate the effect of soft tissue composition on aBMD measured by DXA using a clinical model (i.e. sleeve gastrectomy: SG ) that induces substantial body weight loss.Methods: Areal bone mineral density and body composition (fat mass: FM and lean tissue mass: LTM ) were determined by DXA in 41 obese patients (33 women, 80.5%) just before SG and 1 month later.Results: One month after SG , mean weight loss was −9.8 ± 2.6 kg, with a significant decrease in LTM and FM (kg) ranging from −7.3% to −9.5%. The relative variation in aBMD was increased at the lumbar spine (2.45 ± 3.44%) and decreased at the hip (−1.47 ± 2.28%), whereas no variation was observed for the whole body and radius. The variation in aBMD at the lumbar spine was inversely correlated with variations in weight, whole‐body FM and trunk FM , but not LTM.Conclusion: This study shows evidence of a potential effect of body composition, particularly FM , on aBMD . However, given the modest change in aBMD , which was close to the precision error of aBMD measurements, it appears that significant weight loss does not have a clinically significant impact on the evaluation of aBMD using DXA

Despite a High Prevalence of Menstrual Disorders, Bone Health Is Improved at a Weight-Bearing Bone Site in World-Class Female Rhythmic Gymnasts

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Salivary adiponectin levels are associated with training intensity but not with bone mass or reproductive function in elite Rhythmic Gymnasts

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The quantitative ultrasound method for assessing low bone mass in women with anorexia nervosa

International audienceThis study investigated the potential role of quantitative ultrasound (QUS) to assess low bone mass in anorexia nervosa patients (AN). Bone parameters from QUS and DXA were positively correlated and significantly reduced in AN compared with controls, suggesting that QUS is a pertinent technique to assess low bone mass in these patients.Purpose: The aim of this study was to investigate the potential role of an alternative technique, quantitative ultrasound (QUS), to assess low bone mass in patients with anorexia nervosa (AN).Methods: Two hundred seven young women (134 patients with AN and 73 healthy controls) with ages ranging from 14.4 to 38.4 years participated in this observational cross-sectional study. Bone mass was concomitantly evaluated by DXA to determine areal bone mineral density (aBMD; g/cm2) at hip, lumbar spine, and radius and by QUS to determine broadband ultrasound attenuation (BUA; dB/MHz) at the heel.Results: BUA (66.5 ± 4.6 dB/MHz vs 61.0 ± 5.0 dB/MHz) and aBMD at the hip (0.916 ± 0.013 g/cm2 vs 0.806 ± 0.010 g/cm2), lumbar spine (0.966 ± 0.012 g/cm2 vs 0.886 ± 0.010 g/cm2), and radius (0.545 ± 0.005 g/cm2 vs 0.526 ± 0.04 g/cm2) were significantly decreased (p < 0.01) in patients with AN compared with controls. When patient and control data were pooled, BUA was significantly correlated with aBMD at the hip (r = 0.60, p < 0.001), lumbar spine (r = 0.48, p < 0.001), and radius (r = 0.40, p<0.001). In patients with AN, BUA and aBMD were mainly and positively correlated with weight, lean tissue mass, body mass index (BMI), and minimal BMI life and negatively with the duration of both disease and amenorrhea. Better concordance between the two techniques was obtained when absolute BUA and aBMD values were used according to the WHO T score classification.Conclusion: BUA measurement at the heel by QUS appears to be a pertinent nonionizing technique to assess low bone mass in patients with AN