3,052 research outputs found
Assessment of some variables affecting the blanching activity of betamethasone 17-valerate cream
The effect of concentration and occlusion time on the ability of Betnovate ® cream (betamethasone 17-valerate 0.1%) to produce skin blanching was assessed. Generally, increased concentration or occlusion time produce and increase in the degree of blanching observed, however, a plateau stage is eventually reached where no further increase of blanching occurs
Taming the Yukawa potential singularity: improved evaluation of bound states and resonance energies
Using the tools of the J-matrix method, we absorb the 1/r singularity of the
Yukawa potential in the reference Hamiltonian, which is handled analytically.
The remaining part, which is bound and regular everywhere, is treated by an
efficient numerical scheme in a suitable basis using Gauss quadrature
approximation. Analysis of resonance energies and bound states spectrum is
performed using the complex scaling method, where we show their trajectories in
the complex energy plane and demonstrate the remarkable fact that bound states
cross over into resonance states by varying the potential parameters.Comment: 8 pages, 2 tables, 1 figure. 2 mpg videos and 1 pdf table file are
available upon request from the corresponding Autho
Lagrange-mesh calculations in momentum space
The Lagrange-mesh method is a powerful method to solve eigenequations written
in configuration space. It is very easy to implement and very accurate. Using a
Gauss quadrature rule, the method requires only the evaluation of the potential
at some mesh points. The eigenfunctions are expanded in terms of regularized
Lagrange functions which vanish at all mesh points except one. It is shown that
this method can be adapted to solve eigenequations written in momentum space,
keeping the convenience and the accuracy of the original technique. In
particular, the kinetic operator is a diagonal matrix. Observables in both
configuration space and momentum space can also be easily computed with a good
accuracy using only eigenfunctions computed in the momentum space. The method
is tested with Gaussian and Yukawa potentials, requiring respectively a small
or a great mesh to reach convergence.Comment: Extended versio
Instability of coherent states of a real scalar field
We investigate stability of both localized time-periodic coherent states
(pulsons) and uniformly distributed coherent states (oscillating condensate) of
a real scalar field satisfying the Klein-Gordon equation with a logarithmic
nonlinearity. The linear analysis of time-dependent parts of perturbations
leads to the Hill equation with a singular coefficient. To evaluate the
characteristic exponent we extend the Lindemann-Stieltjes method, usually
applied to the Mathieu and Lame equations, to the case that the periodic
coefficient in the general Hill equation is an unbounded function of time. As a
result, we derive the formula for the characteristic exponent and calculate the
stability-instability chart. Then we analyze the spatial structure of the
perturbations. Using these results we show that the pulsons of any amplitudes,
remaining well-localized objects, lose their coherence with time. This means
that, strictly speaking, all pulsons of the model considered are unstable.
Nevertheless, for the nodeless pulsons the rate of the coherence breaking in
narrow ranges of amplitudes is found to be very small, so that such pulsons can
be long-lived. Further, we use the obtaned stability-instability chart to
examine the Affleck-Dine type condensate. We conclude the oscillating
condensate can decay into an ensemble of the nodeless pulsons.Comment: 11 pages, 8 figures, submitted to Physical Review
Dynamical Casimir effect in oscillating media
We show that oscillations of a homogeneous medium with constant material
coefficients produce pairs of photons. Classical analysis of an oscillating
medium reveals regions of parametric resonance where the electromagnetic waves
are exponentially amplified. The quantum counterpart of parametric resonance is
an exponentially growing number of photons in the same parameter regions. This
process may be viewed as another manifestation of the dynamical Casimir effect.
However, in contrast to the standard dynamical Casimir effect, photon
production here takes place in the entire volume and is not due to time
dependence of the boundary conditions or material constants
Turns in transmembrane helices – determination of the minimal length of a “helical hairpin” and derivation of a fine-grained turn propensity scale
We have recently reported a first experimental turn propensity scale for transmembrane helices. This scale was derived from measurements of how efficiently a given residue placed in the middle of a 40 residue poly(Leu) stretch induces the formation of a "helical hairpin" with two rather than one transmembrane segment. We have now extended these studies, and have determined the minimum length of a poly(Leu) stretch compatible with the formation of a helical hairpin. We have also derived a more fine-grained turn propensity scale by (i) introducing each of the 20 amino acid residues into the middle of the shortest poly(Leu) stretch compatible with helical hairpin formation, and (ii) introducing pairs of residues in the middle of the 40 residue poly(Leu) stretch. The new turn propensities are consistent with the amino acid frequencies found in short hairpin loops in membrane proteins of known 3D structure
Radiative Phase Transitions and Casmir Effect Instabilities
Molecular quantum electrodynamics leads to photon frequency shifts and thus
to changes in condensed matter free energies often called the Casimir effect.
Strong quantum electrodynamic coupling between radiation and molecular motions
can lead to an instability beyond which one or more photon oscillators undergo
a displacement phase transition. The phase boundary of the transition can be
located by a Casimir free energy instability.Comment: ReVTeX4 format 1 *.eps figur
A study on the interaction between metformin and constituents of a commercial herbal product
Purpose: To investigate the interactions between metformin and Yoyo Bitters® including some of its constituents in the management of diabetes mellitus.Method: Using the generic form of metformin (Glucophage®) tablets, tests such as disintegration time, dissolution profile, Fourier transform infrared (FTIR) spectroscopy and in vivo hypoglycaemia tests using Wistar albino rat were performed for metformin to investigate its behaviour in the presence and absence of Yoyo Bitters and some plant extracts used in its formulation.Results: Metformin tablets used met BP specification in terms of pharmaceutical properties. There was no significant change in the disintegration properties of the metformin tablets in the presence of Yoyo Bitters (p > 0.05) while a significant change occurred in the dissolution profile (p < 0.05). The FTIR spectra showed some level of interactions due to disappearance of some spectral peaks. In vivo result showed a significant reduction (p < 0.05) in the duration of action of metformin.Conclusion: Concomitant administration of metformin and Yoyo Bitters showed interaction that appeared antagonistic to the hypoglycaemic effect of metformin both in vitro and in rat modelsKeywords: Metformin, In vitro interactions, Yoyo Bitters, Diabete
Properties of finite Gaussians and the discrete-continuous transition
Weyl's formulation of quantum mechanics opened the possibility of studying
the dynamics of quantum systems both in infinite-dimensional and
finite-dimensional systems. Based on Weyl's approach, generalized by Schwinger,
a self-consistent theoretical framework describing physical systems
characterised by a finite-dimensional space of states has been created. The
used mathematical formalism is further developed by adding finite-dimensional
versions of some notions and results from the continuous case. Discrete
versions of the continuous Gaussian functions have been defined by using the
Jacobi theta functions. We continue the investigation of the properties of
these finite Gaussians by following the analogy with the continuous case. We
study the uncertainty relation of finite Gaussian states, the form of the
associated Wigner quasi-distribution and the evolution under free-particle and
quantum harmonic oscillator Hamiltonians. In all cases, a particular emphasis
is put on the recovery of the known continuous-limit results when the dimension
of the system increases.Comment: 21 pages, 4 figure
Classical and quantum radiation from a moving charge in an expanding universe
We investigate photon emission from a moving particle in an expanding
universe. This process is analogous to the radiation from an accelerated charge
in the classical electromagnetic theory. Using the framework of quantum field
theory in curved spacetime, we demonstrate that the Wentzel-Kramers-Brillouin
(WKB) approximation leads to the Larmor formula for the rate of the radiation
energy from a moving charge in an expanding universe. Using exactly solvable
models in a radiation-dominated universe and in a Milne universe, we examine
the validity of the WKB formula. It is shown that the quantum effect suppresses
the radiation energy in comparison with the WKB formula.Comment: 16 pages, JCAP in pres
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