PAN AIR analysis of the NASA/MCAIR 279-3: An advanced supersonic V/STOL fighter/attack aircraft

PAN AIR is a computer program for predicting subsonic or supersonic linear potential flow about arbitrary configurations. The program was applied to a highly complex single-engine-cruise V/STOL fighter/attack aircraft. Complexities include a close-coupled canard/wing, large inlets, and four exhaust nozzles mounted directly under the wing and against the fuselage. Modeling uncertainties involving canard wake location and flow-through approximation through the inlet and the exhaust nozzles were investigated. The recently added streamline capability of the program was utilized to evaluate visually the predicted flow over the model. PAN AIR results for Mach numbers of 0.6, 0.9, and angles of attack of 0, 5, and 10 deg. were compared with data obtained in the Ames 11- by 11-Foot Transonic Wind tunnel, at a Reynolds number of 3.69 x 10 to the 6th power based on c bar

Sonic boom prediction for the Langley Mach 2 low-boom configuration

Sonic boom pressure signatures and aerodynamic force data for the Langley Mach 2 low sonic boom configuration were computed using the TranAir full-potential code. A solution-adaptive Cartesian grid scheme is utilized to compute off-body flow field data. Computations were performed with and without nacelles at several angles of attack. Force and moment data were computed to measure nacelle effects on the aerodynamic characteristics and sonic boom footprints of the model. Pressure signatures were computed both on and off ground-track. Near-field pressure signature computations on ground-track were in good agreement with experimental data. Computed off ground-track signatures showed that maximum pressure peaks were located off ground-track and were significantly higher than the signatures on ground-track. Bow shocks from the nacelle inlets increased lift and drag, and also increased the magnitude of the maximum pressure both on and off ground-track

TranAir: Recent advances and applications

TranAir is a computer code which solves the full-potential equation for transonic flow about very general and complex configurations. Piecewise flat surface panels are used to describe the surface geometry. This paneled definition is then embedded in an unstructured cartesian flow field grid. Finite elements are used in the discretization of the flow field grid in a manner which is fully conservative and second-order accurate. Since geometries may be defined with relative ease, and since the user is not involved in the generation of the flow field grid, computational results may be generated rather quickly for a wide range of geometries. For transonic cases in the cruise angle-of-attack range, TranAir has generated results which are in generally good agreement with both Euler results and wind tunnel data. A typical transonic case runs in 1 to 2 CPU hours on a Cray X-MP. For subcritical cases, the code runs in 15 to 30 CPU minutes, even for geometries in which several thousand surface panels are used in the definition. This ability to rapidly and accurately provide both subsonic and transonic predictions about very complex aircraft configurations gives TranAir the potential of being a very powerful and widely used design tool

Asfotase alfa therapy for children with hypophosphatasia

Background. Hypophosphatasia (HPP) is caused by loss-of-function mutation(s) of the gene that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). Consequently, cell-surface deficiency of TNSALP phosphohydrolase activity leads to extracellular accumulation of inorganic pyrophosphate, a natural substrate of TNSALP and inhibitor of mineralization. Children with HPP can manifest rickets, skeletal pain, deformity, fracture, muscle weakness, and premature deciduous tooth loss. Asfotase alfa is a recombinant, bone-targeted, human TNSALP injected s.c. to treat HPP. In 2012, we detailed the 1-year efficacy of asfotase alfa therapy for the life-threatening perinatal and infantile forms of HPP. Methods. Here, we evaluated the efficacy and safety of asfotase alfa treatment administered to children 6–12 years of age at baseline who were substantially impaired by HPP. Two radiographic scales quantitated HPP skeletal disease, including comparisons to serial radiographs from similarly affected historical control patients. Results. Twelve children receiving treatment were studied for 5 years. The 6-month primary endpoint was met, showing significant radiographic improvement. Additional significant improvements included patient growth, strength, motor function, agility, and quality of life, which for most patients meant achieving normal values for age- and sex-matched peers that were sustained at 5 years of treatment. For most, pain and disability resolved. Mild to moderate injection-site reactions were common and were sometimes associated with lipohypertrophy. Low anti–asfotase alfa antibody titers were noted in all patients. No evidence emerged for clinically important ectopic calcification or treatment resistance. Conclusions. Asfotase alfa enzyme replacement therapy has substantial and sustained efficacy with a good safety profile for children suffering from HPP. Trial Registration. ClinicalTrials.gov NCT00952484 (https://clinicaltrials.gov/ct2/show/NCT00952484) and NCT01203826 (https://clinicaltrials.gov/ct2/show/NCT01203826). Funding. Alexion Pharmaceuticals Inc. and Shriners Hospitals for Children

Neuroactive substances specifically modulate rhythmic body contractions in the nerveless metazoon Tethya wilhelma (Demospongiae, Porifera)

BACKGROUND: Sponges (Porifera) are nerve- and muscleless metazoa, but display coordinated motor reactions. Therefore, they represent a valuable phylum to investigate coordination systems, which evolved in a hypothetical Urmetazoon prior to the central nervous system (CNS) of later metazoa. We have chosen the contractile and locomotive species Tethya wilhelma (Demospongiae, Hadromerida) as a model system for our research, using quantitative analysis based on digital time lapse imaging. In order to evaluate candidate coordination pathways, we extracorporeally tested a number of chemical messengers, agonists and antagonists known from chemical signalling pathways in animals with CNS. RESULTS: Sponge body contraction of T. wilhelma was induced by caffeine, glycine, serotonine, nitric oxide (NO) and extracellular cyclic adenosine monophosphate (cAMP). The induction by glycine and cAMP followed patterns varying from other substances. Induction by cAMP was delayed, while glycine lead to a bi-phasic contraction response. The frequency of the endogenous contraction rhythm of T. wilhelma was significantly decreased by adrenaline and NO, with the same tendency for cAMP and acetylcholine. In contrast, caffeine and glycine increased the contraction frequency. The endogenous rhythm appeared irregular during application of caffeine, adrenaline, NO and cAMP. Caffeine, glycine and NO attenuated the contraction amplitude. All effects on the endogenous rhythm were neutralised by the washout of the substances from the experimental reactor system. CONCLUSION: Our study demonstrates that a number of chemical messengers, agonists and antagonists induce contraction and/or modulate the endogenous contraction rhythm and amplitude of our nerveless model metazoon T. wilhelma. We conclude that a relatively complex system of chemical messengers regulates the contraction behaviour through auto- and paracrine signalling, which is presented in a hypothetical model. We assume that adrenergic, adenosynergic and glycinergic pathways, as well as pathways based on NO and extracellular cAMP are candidates for the regulation and timing of the endogenous contraction rhythm within pacemaker cells, while GABA, glutamate and serotonine are candidates for the direct coordination of the contractile cells

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

SummaryWe describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs. Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers

Applying for the Predoctoral Internship: Training Program Strategies To Help Students Prepare

The predoctoral internship signifies the culmination of applied training in professional psychology. With the increasing supply and demand gap, securing an internship has become competitive and has resulted in many students employing a wide variety of steps in an attempt to ensure a successful internship application. However, little is known about how academic training programs assist students in applying for an internship. The purpose of this study was to describe what activities training programs engage in to prepare their students for the internship application process, and to better understand students\u27 perception of their preparedness to apply as well as to understand their experience applying. The results suggested that training programs prepared students well for general aspects of the process but did not adequately prepare them for the more specific tasks related to the application process. Results also suggested that while the students didn\u27t find the application process confusing or difficult they found it stressful and anxiety provoking. Suggestions for programs to inform and assist their students in preparing for applying are presented as well as recommendations for future research. (PsycINFO Database Record (c) 2017 APA, all rights reserved

The Supervision Genogram: A Tool for Preparing Supervisors-in-Training

The purpose of this article is to introduce the supervision genogram as a training tool that can be implemented in supervisor training. The supervision genogram is a unique training tool that may be used to enhance supervisors\u27-in-training self-awareness and understanding of the supervisory process. Psychological trainers who are responsible for training supervisors may also find that the supervision genogram can aid them in assessing the needs of supervisors-in-training and in creating corresponding supervisory environments and experiences. A detailed account of how to develop and process the supervision genogram is given. An overview of supervision genogram symbols and a completed supervision genogram are also provided. Implications for training, such as flexibility of application, ethical and professional issues, and developmental considerations for using this tool are discussed