2,390 research outputs found
The Macrame 1024 node switching network
The work reported involves the construction of a large modular testbed using IEEE 1355 DS link technology. A thousand nodes will be interconnected by a switching fabric based on the STC104 packet switch. The system has been designed and constructed in a modular way in order to allow a variety of different network topologies to be investigated. Network throughput and latency have been studied for different network topologies under various traffic conditions
The class of the locus of intermediate Jacobians of cubic threefolds
We study the locus of intermediate Jacobians of cubic threefolds within the
moduli space of complex principally polarized abelian fivefolds, and its
generalization to arbitrary genus - the locus of abelian varieties with a
singular odd two-torsion point on the theta divisor. Assuming that this locus
has expected codimension (which we show to be true for genus up to 5), we
compute the class of this locus, and of is closure in the perfect cone toroidal
compactification, in the Chow, homology, and the tautological ring.
We work out the cases of genus up to 5 in detail, obtaining explicit
expressions for the classes of the closures of the locus of products of an
elliptic curve and a hyperelliptic genus 3 curve, in moduli of principally
polarized abelian fourfolds, and of the locus of intermediate Jacobians in
genus 5. In the course of our computation we also deal with various
intersections of boundary divisors of a level toroidal compactification, which
is of independent interest in understanding the cohomology and Chow rings of
the moduli spaces.Comment: v2: new section 9 on the geometry of the boundary of the locus of
intermediate Jacobians of cubic threefolds. Final version to appear in
Invent. Mat
Homogeneous cosmologies with cosmological constant
Spatially homogeneous cosmological models with a positive cosmological
constant are investigated, using dynamical systems methods. We focus on the
future evolution of these models. In particular, we address the question
whether there are models within this class that are de Sitter-like in the
future, but are tilted.Comment: 10 pages, 13 eps-figures. Submitted to Phys. Rev.
Kinetic models for estimating occupancy from single-scan PET displacement studies
The traditional design of PET target engagement studies is based on a baseline scan and one or more scans after drug administration. We here evaluate an alternative design in which the drug is administered during an on-going scan (i.e., a displacement study). This approach results both in lower radiation exposure and lower costs. Existing kinetic models assume steady state. This condition is not present during a drug displacement and consequently, our aim here was to develop kinetic models for analysing PET displacement data. We modified existing compartment models to accommodate a time-variant increase in occupancy following the pharmacological in-scan intervention. Since this implies the use of differential equations that cannot be solved analytically, we developed instead one approximate and one numerical solution. Through simulations, we show that if the occupancy is relatively high, it can be estimated without bias and with good accuracy. The models were applied to PET data from six pigs where [11C]UCB-J was displaced by intravenous brivaracetam. The dose-occupancy relationship estimated from these scans showed good agreement with occupancies calculated with Lassen plot applied to baseline-block scans of two pigs. In summary, the proposed models provide a framework to determine target occupancy from a single displacement scan.</p
Associations of Plasma Nitrite, L-Arginine and Asymmetric Dimethylarginine With Morbidity and Mortality in Patients With Necrotizing Soft Tissue Infections
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