Comparative study of albumin 5% solution with Ringer's lactate for substitute blood loss of intra-operation on the integrity of the patient's coagulation system, renal function and electrolytes after surgery; a double-blind clinical trial study

Introduction: The type of fluid replace sufficient volume loss during surgery is crucial for normal renal functioning. Objectives: The aim of this study was to compare the effect of albumin 5% infusion versus Ringer's lactate solution on substitution of intraoperative bleeding on the status of the patient's hemodynamic and coagulation system after surgery. Patients and Methods: This clinical trial study was performed on 80 patients with non-emergency surgery with the possibility of intraoperative bleeding. Bleeding replacement was performed in the control group with Ringer's lactate serum and in the case group was replaced with 5% albumin. Patients' coagulation status (prothrombin time [PT] and relative thromboplastin time and international normalized ratio; INR), electrolyte concentrations (sodium, potassium, and calcium), renal activity tests (serum urea and creatinine) were performed before and at 6, 12, and 24 hours after anesthesia. Results: The results of the study showed no significant difference between the two groups regarding renal parameters, electrolytes (sodium, potassium and calcium) in all stages of the study. Additionally, PT and partial thromboplastin time (PPT) at 6, 12, and 24 hours post-operation in albumin receiving group was less than that of the Ringer's lactate group (P < 0.01). Additionally, 12 and 24 hours after operation, the INR was significantly less in the albumin group compared to Ringer's lactate serum receiver (P < 0.05). Conclusion: This study showed that the administration of albumin solution in comparison with Ringer's lactate for replacement of intraoperative bleeding reduces the risk of bleeding after surgery due to less coagulation disorder. Keywords:Albumin; Ringer's lactate; Prothrombin time (PT); Partial thromboplastin time; International normalized rati