1 research outputs found
H‑Gemcitabine: A New Gemcitabine Prodrug for Treating Cancer
In this report, we present a new strategy for targeting
chemotherapeutics
to tumors, based on targeting extracellular DNA. A gemcitabine prodrug
was synthesized, termed H-gemcitabine, which is composed of Hoechst
conjugated to gemcitabine. H-gemcitabine has low toxicity because
it is membrane-impermeable; however, it still has high tumor efficacy
because of its ability to target gemcitabine to E-DNA in tumors. We
demonstrate here that H-gemcitabine has a wider therapeutic window
than free gemcitabine