General characteristics of the Portuguese discovery and replication datasets.

<p>IA: Intracranial aneurysm; ys: years; SAH: subarachnoid hemorrhage; SD: Standard deviation.</p><p>General characteristics of the Portuguese discovery and replication datasets.</p

IA association results for the SNPs associated in the discovery, replication and combined datasets.

<p>Odds ratios (OR) and 95% confidence intervals (CI) are relative to the allele on the forward strand of the human genome reference sequence and are only shown for those markers with nominally significant associations (<i>P</i>_<i>adj</i>≤5.00E-02). Significant associations are highlighted in bold.</p><p>SNP: Single nucleotide polymorphism; kb: Kilobase pairs; F_cases and F_controls: Allele frequency in cases and controls, respectively; <i>P</i>: Allelic qui-square P-value. <i>P</i>_<i>adj</i>: <i>P</i>-values from logistic regression using log-additive model are adjusted for hypertension in the discovery dataset, for hypertension and smoking habits in the replication and combined datasets; <i>UBR3</i>: ubiquitin protein ligase E3 component n-recognin 3 gene; <i>MYO3B</i>: myosin IIIB gene; <i>SCN11A</i>: sodium channel, voltage-gated, type XI, alpha subunit gene; <i>WDR48</i>: WD repeat domain 48 gene; <i>PRDM9</i>: PR domain containing 9 gene; <i>HTR1B</i>: 5-hydroxytryptamine (serotonin) receptor 1B gene.</p><p>IA association results for the SNPs associated in the discovery, replication and combined datasets.</p