54 research outputs found
Monitoring the impacts of trade agreements on food environments
The liberalization of international trade and foreign direct investment through
multilateral, regional and bilateral agreements has had profound implications
for the structure and nature of food systems, and therefore, for the availability,
nutritional quality, accessibility, price and promotion of foods in different
locations. Public health attention has only relatively recently turned to the links
between trade and investment agreements, diets and health, and there is currently
no systematic monitoring of this area. This paper reviews the available evidence on the links between trade agreements, food environments and diets from an obesity and non-communicable disease (NCD) perspective. Based on the key issues identified through the review, the paper outlines an approach for monitoring the potential impact of trade agreements on food environments and
obesity/NCD risks. The proposed monitoring approach encompasses a set of guiding principles, recommended procedures for data collection and analysis, and quantifiable ‘minimal’, ‘expanded’ and ‘optimal’ measurement indicators to be tailored to national priorities, capacity and resources. Formal risk assessment processes of existing and evolving trade and investment agreements,
which focus on their impacts on food environments will help inform the development of healthy trade policy, strengthen domestic nutrition and health
policy space and ultimately protect population nutrition.The following organizations provided funding support for the travel of participants
to Italy for this meeting and the preparation of background research papers: The Rockefeller Foundation, International Obesity Taskforce (IOTF), University of
Auckland, Deakin University, The George Institute, University of Sydney, Queensland University of Technology, University
of Oxford, University of Pennsylvania Perelman School of Medicine, World Cancer Research Fund International, University of Toronto, and The Australian National
University. The Faculty of Health at Deakin University kindly supported the costs for open access availability of this paper,
and the Australian National Health and Medical Research Council Centre for Research Excellence in Obesity Policy and Food Systems (APP1041020) supported the coordination and finalizing of INFORMAS manuscripts
A proposed approach to monitor private-sector policies and practices related to food environments, obesity and non-communicable disease prevention
Private-sector organizations play a critical role in shaping the food environments
of individuals and populations. However, there is currently
very limited independent monitoring of private-sector actions related to
food environments. This paper reviews previous efforts to monitor the
private sector in this area, and outlines a proposed approach to monitor
private-sector policies and practices related to food environments, and
their influence on obesity and non-communicable disease (NCD) prevention.
A step-wise approach to data collection is recommended, in which
the first (‘minimal’) step is the collation of publicly available food and
nutrition-related policies of selected private-sector organizations. The
second (‘expanded’) step assesses the nutritional composition of each
organization’s products, their promotions to children, their labelling
practices, and the accessibility, availability and affordability of their
products. The third (‘optimal’) step includes data on other commercial
activities that may influence food environments, such as political lobbying
and corporate philanthropy. The proposed approach will be further
developed and piloted in countries of varying size and income levels.
There is potential for this approach to enable national and international
benchmarking of private-sector policies and practices, and to inform
efforts to hold the private sector to account for their role in obesity and
NCD prevention
Balancing the benefits and risks of public–private partnerships to address the global double burden of malnutrition
Objective: Transnational food, beverage and restaurant companies, and their corporate foundations, may be potential collaborators to help address complex public health nutrition challenges. While UN system guidelines are available for private-sector engagement, non-governmental organizations (NGO) have limited guidelines to navigate diverse opportunities and challenges presented by partnering with these companies through public–private partnerships (PPP) to address the global double burden of malnutrition.Design: We conducted a search of electronic databases, UN system websites and grey literature to identify resources about partnerships used to address the global double burden of malnutrition. A narrative summary provides a synthesis of the interdisciplinary literature identified.Results: We describe partnership opportunities, benefits and challenges; and tools and approaches to help NGO engage with the private sector to address global public health nutrition challenges. PPP benefits include: raising the visibility of nutrition and health on policy agendas; mobilizing funds and advocating for research; strengthening food-system processes and delivery systems; facilitating technology transfer; and expanding access to medications, vaccines, healthy food and beverage products, and nutrition assistance during humanitarian crises. PPP challenges include: balancing private commercial interests with public health interests; managing conflicts of interest; ensuring that co-branded activities support healthy products and healthy eating environments; complying with ethical codes of conduct; assessing partnership compatibility; and evaluating partnership outcomes.Conclusions: NGO should adopt a systematic and transparent approach using available tools and processes to maximize benefits and minimize risks of partnering with transnational food, beverage and restaurant companies to effectively target the global double burden of malnutrition.<br /
Monitoring food and non-alcoholic beverage promotions to children
Food and non-alcoholic beverage marketing is recognized as an important factor influencing food choices related to non-communicable diseases. The monitoring of populations\u27 exposure to food and non-alcoholic beverage promotions, and the content of these promotions, is necessary to generate evidence to understand the extent of the problem, and to determine appropriate and effective policy responses. A review of studies measuring the nature and extent of exposure to food promotions was conducted to identify approaches to monitoring food promotions via dominant media platforms. A step-wise approach, comprising \u27minimal\u27, \u27expanded\u27 and \u27optimal\u27 monitoring activities, was designed. This approach can be used to assess the frequency and level of exposure of population groups (especially children) to food promotions, the persuasive power of techniques used in promotional communications (power of promotions) and the nutritional composition of promoted food products. Detailed procedures for data sampling, data collection and data analysis for a range of media types are presented, as well as quantifiable measurement indicators for assessing exposure to and power of food and non-alcoholic beverage promotions. The proposed framework supports the development of a consistent system for monitoring food and non-alcoholic beverage promotions for comparison between countries and over time
Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types
Background: Single-cell genomic methods now provide unprecedented resolution for characterizing the component cell types and states of tissues such as the epithelial subsets of the gastrointestinal tract. Nevertheless, functional studies of these subsets at scale require faithful in vitro models of identified in vivo biology. While intestinal organoids have been invaluable in providing mechanistic insights in vitro, the extent to which organoid-derived cell types recapitulate their in vivo counterparts remains formally untested, with no systematic approach for improving model fidelity. Results: Here, we present a generally applicable framework that utilizes massively parallel single-cell RNA-seq to compare cell types and states found in vivo to those of in vitro models such as organoids. Furthermore, we leverage identified discrepancies to improve model fidelity. Using the Paneth cell (PC), which supports the stem cell niche and produces the largest diversity of antimicrobials in the small intestine, as an exemplar, we uncover fundamental gene expression differences in lineage-defining genes between in vivo PCs and those of the current in vitro organoid model. With this information, we nominate a molecular intervention to rationally improve the physiological fidelity of our in vitro PCs. We then perform transcriptomic, cytometric, morphologic and proteomic characterization, and demonstrate functional (antimicrobial activity, niche support) improvements in PC physiology. Conclusions: Our systematic approach provides a simple workflow for identifying the limitations of in vitro models and enhancing their physiological fidelity. Using adult stem cell-derived PCs within intestinal organoids as a model system, we successfully benchmark organoid representation, relative to that in vivo, of a specialized cell type and use this comparison to generate a functionally improved in vitro PC population. We predict that the generation of rationally improved cellular models will facilitate mechanistic exploration of specific disease-associated genes in their respective cell types. Electronic supplementary material The online version of this article (10.1186/s12915-018-0527-2) contains supplementary material, which is available to authorized users
Developing a standardized approach for monitoring food marketing to children
Abstract presented at the 2013 Annual Meeting of the International Society for Behavioral Nutrition and Physical Activity, 22-25 May 2013, Ghent, Belgiu
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