129 research outputs found

    Health and safety in the United Kingdom higher education libraries: a review of the literature

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    The focus of this article is to review the literature relating to health and safety in UK Higher Education libraries. This will include an overview of the literature on accident theories and also the human element. Various key findings emerge from this analysis. Personal safety is achieved through self-responsibility, following guidelines and having a working knowledge of reporting procedures. A safety culture in the work environment is developed through a proactive approach on the part of management, the provision of information, training, and carrying out safety inspections. These inspections are aimed at preventing the environment from creating a situation where an accident could occur. There can never be a work environment in which no accidents will occur and best practice can only minimize the risk of accidents

    The management of absence: why it matters : an analysis of absence management issues, with a case study based in a UK academic library

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    This paper seeks to give an overview of some ongoing research into absence management practices in a UK university library. The aim of the research in question is to evaluate the effectiveness of current management practices

    Human Uterine Biopsy: Research Value and Common Pitfalls.

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    The human uterus consists of the inner endometrium, the myometrium, and the outer serosa. Knowledge of the function of the uterus in health and disease is relevant to reproduction, fertility, embryology, gynaecology, endocrinology, and oncology. Research performed on uterine biopsies is essential to further the current understanding of human uterine biology. This brief review explores the value of the uterine biopsy in gynaecological and human fertility research and explores the common problems encountered when analysing data generated from different types of uterine biopsies, with the aim of improving the quality, reproducibility, and clinical translatability of future research

    Endometrial Stem Cell Markers: Current Concepts and Unresolved Questions

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    The human endometrium is a highly regenerative organ undergoing over 400 cycles of shedding and regeneration over a woman’s lifetime. Menstrual shedding and the subsequent repair of the functional layer of the endometrium is a process unique to humans and higher-order primates. This massive regenerative capacity is thought to have a stem cell basis, with human endometrial stromal stem cells having already been extensively studied. Studies on endometrial epithelial stem cells are sparse, and the current belief is that the endometrial epithelial stem cells reside in the terminal ends of the basalis glands at the endometrial/myometrial interface. Since almost all endometrial pathologies are thought to originate from aberrations in stem cells that regularly regenerate the functionalis layer, expansion of our current understanding of stem cells is necessary in order for curative treatment strategies to be developed. This review critically appraises the postulated markers in order to identify endometrial stem cells. It also examines the current evidence supporting the existence of epithelial stem cells in the human endometrium that are likely to be involved both in glandular regeneration and in the pathogenesis of endometrial proliferative diseases such as endometriosis and endometrial cancer

    Interagency adult support and protection practice of police and health and social care professionals: a realistic evaluation approach.

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    The purpose of this project was to investigate the interagency Adult Support and Protection practices of police, health and social care professionals in Scotland by means of a Realistic Evaluation Approach. The study comprised of two specific phases. The first phase sought to establish the 'state of play' for cross boundary working by: identifying the gaps in interagency practice; evaluating the education and training needs of professionals working in the area of adult support and protection, and identifying information sharing practices. Focus groups with members of the police and health and social care professionals were conducted in each of the three Police Scotland Command areas. Thirteen focus groups were conducted, with 101 professionals participating. Nine key themes were identified: Information sharing; relationships; people and processes; lessons from child protection; environment; implementation of the act; regional variations and training; rights of the service users. The second phase will inform the development and evaluation of future interprofessional training resources and identify key performance indicators (KPIs). These KPIs will enable subsequent evaluation and monitoring of practice for all professionals involved in adult support and protection

    Developing a Preoperative Algorithm for the Diagnosis of Uterine Leiomyosarcoma

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    Early diagnosis of the rare and life-threatening uterine leiomyosarcoma (LMS) is essential for prompt treatment, to improve survival. Preoperative distinction of LMS from benign leiomyoma remains a challenge, and thus LMS is often diagnosed post-operatively. This retrospective observational study evaluated the predictive diagnostic utility of 32 preoperative variables in 190 women who underwent a hysterectomy, with a postoperative diagnosis of leiomyoma (n = 159) or LMS (n = 31), at the Liverpool Women’s National Health Service (NHS) Foundation Trust, between 2010 and 2019. A total of 7 preoperative variables were associated with increased odds of LMS, including postmenopausal status (p < 0.001, OR 3.08), symptoms of pressure (p = 0.002, OR 2.7), postmenopausal bleeding (p = 0.001, OR 5.01), neutrophil count ≥7.5 × 109/L (p < 0.001, OR 5.72), haemoglobin level <118 g/L (p = 0.037, OR 2.22), endometrial biopsy results of cellular atypia or neoplasia (p = 0.001, OR 9.6), and a mass size of ≥10 cm on radiological imaging (p < 0.0001, OR 8.52). This study has identified readily available and easily identifiable preoperative clinical variables that can be implemented into clinical practice to discern those with high risk of LMS, for further specialist investigations in women presenting with symptoms of leiomyoma

    Endometriosis and the Fallopian Tubes: Theories of Origin and Clinical Implications

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    Endometriosis is a common, oestrogen driven chronic condition, where endometrium-like epithelial and stromal cells exist in ectopic sites. At present, no curative treatments are available and the existing evidence for disease progression is conflicting. The pathogenesis is still unknown and evidently complex, as mechanisms of initiation may depend on the anatomical distribution of endometriotic lesions. However, amongst the numerous theories and plethora of mechanisms, contributions of the fallopian tubes (FT) to endometriosis are rarely discussed. The FT are implicated in all endometriosis associated symptomatology and clinical consequences; they may contribute to the origin of endometriotic tissue, determine the sites for ectopic lesion establishment and act as conduits for the spread of proinflammatory media. Here, we examine the available evidence for the contribution of the human FT to the origin, pathogenesis and symptoms/clinical consequences of endometriosis. We also examine the broader topic linking endometriosis and the FT epithelium to the genesis of ovarian epithelial cancers. Further studies elucidating the distinct functional and phenotypical characteristics of FT mucosa may allow the development of novel treatment strategies for endometriosis that are potentially curative
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