Assessment of Independent Living Skills for Adults with Intellectual and Developmental Disabilities: The BrightStone Experience

Mission: ”To provide a comprehensive work, socialsupport, and residential community for adults withspecial needs, expanding their potential and helpingthem develop mentally, physically, socially, emotionally,and spiritually.- Vision: “Our vision is to provide whole life care,meeting the needs of job, home, recreation and social,physical, and health in a God-centered, caringenvironment.”- Background: BrightStone recently purchased 138 acres of land in Williamson County, which will be used toprovide job training, life skills classes, therapeuticactivities, and community living opportunities for adultswith intellectual and developmental disabilities (IDD)

Virtual Teams In Higher Education: The Light And Dark Side

Students and faculty are grappling with learning teams in the online environment - more than half of all higher education organizations offer online courses (Hoffman, 2006). As online course developers try to replicate the best practices of traditional classrooms, the asynchronous technology of the Internet has added great capability while also increasing the confusion that distance in space and time can add to the learning process. This study conducted a qualitative survey of online learning teams using content analysis by three researchers and grounded theory by the fourth researcher. Analysis of the rich text responses prompted the researchers to propose a model for online team development that reflected the functionality or dysfunctionality of teams. Key influences related to the internal or external locus of control of conscientious students. Key findings include strong connections between conscientiousness and attitude towards teamwork on the input side with satisfaction and trust for outcomes. Unlike other research, these online teams linked performance not to pedagogy, but conscientiousness, attitude towards teamwork, and trust. Technology did not hinder performance, suggesting that the new generation of learners is more comfortable with online interactions. The study detected a new factor, team leadership, as a core issue limiting learning and success within teams

From Zoom to the Clinic: Unique Student Challenges in Physical Therapy Clinical Education

While the abrupt shift in PT education (PTE) brought on by the pandemic created opportunities for educational innovation, it also brought relational separation and fragmented learning due to lockdowns, social distancing, face masks, and communication limited to virtual platforms. Academic programs increased use of virtual learning, rearranged curriculum, reduced lab and simulated learning time, and provided fewer, if any, opportunities for service learning and patient contact. Clinic sites paused clinic education experiences or hosted fewer students to maintain social distancing and limit disease exposure. As PTE returns to more typical curricular schedules and practices, it is important to be aware of the current challenges students may be facing. Common challenges include not only increased levels of anxiety and depression, but also problems with self-esteem and confidence, resilience, a growth mindset, and metacognition. This session will investigate the implications of the rise in prevalence of issues in internalizing professional identity and clinical competency for clinical education; the characteristics of unique mental health challenges, such as impostor phenomenon, compassion fatigue, and burnout; screening tools; and suggestions for successfully mentoring students who have low self-esteem, a lack of confidence, decreased resiliency, and imposter feelings

Building H.O.U.S.E (Healthy Outcomes Using a Supportive Environment): Exploring the Role of Affordable and Inclusive Housing for LGBTQIA+ Older Adults

Little is known about how permanent, inclusive, affordable, and supportive long‐term housing may affect the health of low‐income lesbian, gay, bisexual, transgender, queer, intersex, asexual and/or another identity (LGBTQIA+) older adults. Focus group interviews were conducted with 21 older adults to explore the lived experiences and potential health benefits of living in a new LGBTQIA+‐welcoming senior housing. Participants reported that moving into the housing was associated with benefits for health and well‐being, especially for psychological health. Community, social support, and in‐house services were particularly important. However, the combined nature of LGBTQIA+‐welcoming and older adult only housing evoked mixed feelings. Appropriate and accessible housing solutions are essential for LGBTQIA+ older adults and may help address health disparities for these populations

Tobacco Town: Computational Modeling of Policy Options to Reduce Tobacco Retailer Density

To identify the behavioral mechanisms and effects of tobacco control policies designed to reduce tobacco retailer density

"This isn't what war is like" : an ethnographic account of ArmA3

This thesis examines the social practices of the Armed Assault 3 (ArmA 3) gaming community and their attempts to recreate a realistic combat experience online. Using an ethnographic approach, I explore the numerous military simulation (milsim) gaming practices employed by the community, many of which relied heavily on modeling and simulations processes. I contend that these practices were a response to the ‘gaps’ between the ‘real’ and the ‘virtual,’ which disrupted the gaming community’s ability to achieve the desired combat experience. An analysis of these practices makes evident what was deemed necessary for a meaningful and realistic online experience by a diverse community, as well as the new layers of gaps produced by the gamers themselves.Social Science and Humanities Research Counci

Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis

Age-related decreases in autophagy contribute to the progression of age-related macular degeneration (AMD). We have now studied the interaction between autophagy impaired in retinal pigment epithelium (RPE) and the responses of macrophages. We find that dying RPE cells can activate the macrophage inflammasome and promote angiogenesis. In vitro, inhibiting rotenone-induced autophagy in RPE cells elicits caspase-3 mediated cell death. Co-culture of damaged RPE with macrophages leads to the secretion of IL-1β, IL-6 and nitrite oxide. Exogenous IL-6 protects the dysfunctional RPE but IL-1β causes enhanced cell death. Furthermore, IL-1β toxicity is more pronounced in dysfunctional RPE cells showing reduced IRAK3 gene expression. Co-culture of macrophages with damaged RPE also elicits elevated levels of pro-angiogenic proteins that promote ex vivo choroidal vessel sprouting. In vivo, impaired autophagy in the eye promotes photoreceptor and RPE degeneration and recruitment of inflammasome-activated macrophages. The degenerative tissue environment drives an enhanced pro-angiogenic response, demonstrated by increased size of laser-induced choroidal neovascularization (CNV) lesions. The contribution of macrophages was confirmed by depletion of CCR2 + monocytes, which attenuates CNV in the presence of RPE degeneration. Our results suggest that the interplay between perturbed RPE homeostasis and activated macrophages influences key features of AMD development

Asfotase alfa therapy for children with hypophosphatasia

Background. Hypophosphatasia (HPP) is caused by loss-of-function mutation(s) of the gene that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). Consequently, cell-surface deficiency of TNSALP phosphohydrolase activity leads to extracellular accumulation of inorganic pyrophosphate, a natural substrate of TNSALP and inhibitor of mineralization. Children with HPP can manifest rickets, skeletal pain, deformity, fracture, muscle weakness, and premature deciduous tooth loss. Asfotase alfa is a recombinant, bone-targeted, human TNSALP injected s.c. to treat HPP. In 2012, we detailed the 1-year efficacy of asfotase alfa therapy for the life-threatening perinatal and infantile forms of HPP. Methods. Here, we evaluated the efficacy and safety of asfotase alfa treatment administered to children 6–12 years of age at baseline who were substantially impaired by HPP. Two radiographic scales quantitated HPP skeletal disease, including comparisons to serial radiographs from similarly affected historical control patients. Results. Twelve children receiving treatment were studied for 5 years. The 6-month primary endpoint was met, showing significant radiographic improvement. Additional significant improvements included patient growth, strength, motor function, agility, and quality of life, which for most patients meant achieving normal values for age- and sex-matched peers that were sustained at 5 years of treatment. For most, pain and disability resolved. Mild to moderate injection-site reactions were common and were sometimes associated with lipohypertrophy. Low anti–asfotase alfa antibody titers were noted in all patients. No evidence emerged for clinically important ectopic calcification or treatment resistance. Conclusions. Asfotase alfa enzyme replacement therapy has substantial and sustained efficacy with a good safety profile for children suffering from HPP. Trial Registration. ClinicalTrials.gov NCT00952484 (https://clinicaltrials.gov/ct2/show/NCT00952484) and NCT01203826 (https://clinicaltrials.gov/ct2/show/NCT01203826). Funding. Alexion Pharmaceuticals Inc. and Shriners Hospitals for Children

Measuring cervical cancer risk: development and validation of the CARE Risky Sexual Behavior Index

To develop and validate a risky sexual behavior index specific to cervical cancer research