Energy Issues in Canada

During the Fall Semester, 1977 the Department of Geography and ContinuingStudies, Simon Fraser University presented a public lecture series, \u27EnergyIssues in Canada.\u27 The series was intended as a forum for public debate, with six lectures presented by experts playing significant roles in today\u27s energydecisions. The lectures addressed a range of topics, including energy supplyand demand forecasts, the problems and potential of fossil fuels, the opportunitiesoffered by renewable energy sources, and energy conservation. Thefinal lecture in the series focussed upon current federal energy policy.In response to the interest shown in the series, we decided to issue avolume of proceedings in order that the infonnation and viewpoints presentedin the lectures could reach a wider audience. The following papers arearranged in order of presentation. Unfortunately it has not been possible toinclude the discussion of renewable energy sources and technologies given inthe fifth lecture of the series. Most authors address the Canadian and provincial energy scene in thecontext of world trends: the price increases introduced by OPEC (Organisationof Petroleum Exporting Countries) in 1973, and the looming gap between worlddemand and supply of petroleum which will result in a deficit sometime duringthe 1980s. These trends have undermined our sense of energy security, forceda reexamination of present energy use patterns, and given support to theidea of energy conservation

On the prebiotic potential of reduced oxidation state phosphorus:The H-phosphinate-pyruvate system

H-Phosphinic acid and pyruvic acid, both plausible prebiotic chemicals, react selectively in water to build structural complexity including amide bond formation under remarkably mild conditions and oxidative coupling of P 1 compounds to condensed pyrophosphorus compounds.</p

On the Prebiotic Potential of Reduced Oxidation State Phosphorus: the H-phosphinate–pyruvate System

H-Phosphinic acid and pyruvic acid, both plausible prebiotic chemicals, react selectively in water to build structural complexity including amide bond formation under remarkably mild conditions and oxidative coupling of P1 compounds to condensed pyrophosphorus compounds

Evidence for a geochemical origin of the mysterious circles in the Pro-Namib desert

The origin of the so-called “fairy circles” has not yet been established. Carbon monoxide (as an indicator of a natural gas microseep) was monitored inside and outside of the selected fairy circles in the Namib, Namibia, Southern Africa. Hydrocarbons were extracted from the soil by a novel method for trapping analytes onto silicone rubber designed for thermal desorption into a gas chromatographemass spectrometer GCeMS). Unresolved complex mixtures with resolvable alkanes were detected in soil collected from two newly formed circles. Alkenes, the microbial degradation product of alkanes (microbial food source), were more abundant in the circles compared to the levels of alkenes detected in the matrix between circles. Results show a microseepage of gases and hydrocarbons which is expressed at the surface as a geobotanical anomaly of barren circles and circles of altered vegetation. In addition, this finding may suggest a new approach to the origin of the mima mounds (heuweltjies) of the Western Cape in South Africa

Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients

&lt;p&gt;Purpose: Cell-based approaches were used to identify genetic markers predictive of patients' risk for poor response prior to chemotherapy.&lt;/p&gt; &lt;p&gt;Experimental Design: We conducted genome-wide association studies (GWAS) to identify single-nucleotide polymorphisms (SNP) associated with cellular sensitivity to carboplatin through their effects on mRNA expression using International HapMap lymphoblastoid cell lines (LCL) and replicated them in additional LCLs. SNPs passing both stages of the cell-based study were tested for association with progression-free survival (PFS) in patients. Phase 1 validation was based on 377 ovarian cancer patients receiving at least four cycles of carboplatin and paclitaxel from the Australian Ovarian Cancer Study (AOCS). Positive associations were then assessed in phase 2 validation analysis of 1,326 patients from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas.&lt;/p&gt; &lt;p&gt;Results: In the initial GWAS, 342 SNPs were associated with carboplatin-induced cytotoxicity, of which 18 unique SNPs were retained after assessing their association with gene expression. One SNP (rs1649942) was replicated in an independent LCL set (Bonferroni adjusted P &lt; 0.05). It was found to be significantly associated with decreased PFS in phase 1 AOCS patients (P(per-allele) = 2 x 10(-2)), with a stronger effect in the subset of women with optimally debulked tumors (P(per-allele) = 4 x 10(-3)). rs1649942 was also associated with poorer overall survival in women with optimally debulked tumors (P(per-allele) = 9 x 10(-3)). However, this SNP was not significant in phase 2 validation analysis with patients from numerous cohorts.&lt;/p&gt; &lt;p&gt;Conclusion: This study shows the potential of cell-based, genome-wide approaches to identify germline predictors of treatment outcome and highlights the need for extensive validation in patients to assess their clinical effect.&lt;/p&gt

Changes in Care- A Systematic Scoping Review of Transitions for Children with Medical Complexities

Background: Children with medical complexity (CMC) and their parents are affected physically and mentally during transitions in care. Coordinated models of care show promise in improving health outcomes. Objective: The purpose of this scoping review was to examine research related to CMC and their parents and transitions in care. The aim was 3-fold: (1) to examine the extent, range, and nature of research activity related to the impact of transitions on physical and mental health for CMC and their parents; (2) to summarize and disseminate research findings for key knowledge users; and (3) to identify research gaps in the existing literature to inform future studies. Methods: Twenty-three sources were identified through database searches and five articles met the inclusion criteria of CMC (multi-organ involvement or technology-dependent) (or parents of CMC) transitioning from hospital to alternate levels of care where outcome measures were physical or mental health-related. Results: Numerical analysis revealed substantial variation in methodological approaches and outcome measures. Content analysis revealed two themes for parents of CMC during this transition: (1) emotional distress, and (2) high expectations; and three themes for CMC: (1) improved health, (2) changes in emotion, and (3) disrupted relationships. Conclusion: The findings from this scoping review reveal for parents, transitions in care are fraught with emotional distress and high expectations; and for CMC there are improvements in quality of life and emotional health post-hospital to home transitions when collaborative models of care are available. This review serves as an early attempt to summarize the literature and demonstrate a need for further research