STRUCTURAL CHANGE IN U.S. CHICKEN AND TURKEY SLAUGHTER

Cost function analyses using data from the U.S. Bureau of the Census reveal substantial scale economies in chicken and turkey slaughter. These economies show no evidence of diminishing as plant size increases, are much greater than those realized in cattle and hog slaughter, and have resulted in a huge increase in plant size over the 1972-92 period. The findings also suggest that consolidation in the chicken and turkey slaughter industry is likely to continue, particularly if the growth in the demand for poultry diminishes.chicken slaughter, turkey slaughter, production costs, structural change, Livestock Production/Industries,

STRUCTURAL CHANGE IN THE U.S. MEAT AND POULTRY INDUSTRIES

Market structure, concentration, meat industry, poultry industry, Industrial Organization,

CONSOLIDATION IN U.S. MEATPACKING

Meatpacking consolidated rapidly in the last two decades: slaughter plants became much larger, and concentration increased as smaller firms left the industry. We use establishment-based data from the U.S. Census Bureau to describe consolidation and to identify the roles of scale economies and technological change in driving consolidation. Through the 1970's, larger plants paid higher wages, generating a pecuniary scale diseconomy that largely offset the cost advantages that technological scale economies offered large plants. The larger plants' wage premium disappeared in the 1980's, and technological change created larger and more extensive technological scale economies. As a result, large plants realized growing cost advantages over smaller plants, and production shifted to larger plants.Concentration, consolidation, meatpacking, scale economies, structural change, Industrial Organization, Livestock Production/Industries,

A W:B4C multilayer phase retarder for broadband polarization analysis of soft x-ray radiation \ud

A W:B4C multilayer phase retarder has been designed and characterized which shows a nearly constant phase retardance between 640 and 850 eV photon energies when operated near the Bragg condition. This freestanding transmission multilayer was used successfully to determine, for the first time, the full polarization vector at soft x-ray energies above 600 eV, which was not possible before due to the lack of suitable optical elements. Thus, quantitative polarimetry is now possible at the 2p edges of the magnetic substances Fe, Co, and Ni for the benefit of magnetic circular dichroism spectroscopy employing circularly polarized synchrotron radiatio

The Conditions of Malaria Transmission in Kuala Penyu District, Sabah and the Residual Effects of Sumithion, Ddt and Malathion

During 1976 - 1977, the Sabah Malaria Control Programme carried out an extended field trial com­paring the residual effects of Summithiona, DDT and Malathionb against the primary vector of Sabah, An. balabacensis balabacensis Baisas in Kuala Penyu district. In the courseof this work and continuiting into 1978, a study was made of the conditions of increased malaria transmission in 3 areas four month after residual applications of Sumithion, DDT and Malathion. Since the findings relate to the south­western part of Sabah which suffers annual anticipated seasonal outbreaks of malaria they are of parti­cular epidemiological interes

Recurrence formulas for Macdonald polynomials of type A

We consider products of two Macdonald polynomials of type A, indexed by dominant weights which are respectively a multiple of the first fundamental weight and a weight having zero component on the k-th fundamental weight. We give the explicit decomposition of any Macdonald polynomial of type A in terms of this basis.Comment: 18 pages, LaTeX, revised version, to appear in Journal of Algebraic Combinatoric

Mechanical Evidence of the Orbital Angular Momentum to Energy Ratio of Vortex Beams

We measure, in a single experiment, both the radiation pressure and the torque due to a wide variety of propagating acoustic vortex beams. The results validate, for the first time directly, the theoretically predicted ratio of the orbital angular momentum to linear momentum in a propagating beam. We experimentally determine this ratio using simultaneous measurements of both the levitation force and the torque on an acoustic absorber exerted by a broad range of helical ultrasonic beams produced by a 1000-element matrix transducer array. In general, beams with helical phase fronts have been shown to contain orbital angular momentum as the result of the azimuthal component of the Poynting vector around the propagation axis. Theory predicts that for both optical and acoustic helical beams the ratio of the angular momentum current of the beam to the power should be given by the ratio of the beam’s topological charge to its angular frequency. This direct experimental observation that the ratio of the torque to power does convincingly match the expected value (given by the topological charge to angular frequency ratio of the beam) is a fundamental result

‘Real-life’ reduction in cholesterol with statins, 1993 to 2002

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: * Statins reduce cholesterol concentrations and cardiovascular events in randomized clinical trials. * Much less is known about their impact in the setting of normal care. WHAT THIS STUDY ADDS: * This is the first study to assess the effectiveness of lipid-lowering treatment in the general population. * We have also estimated the resultant impact on major vascular events. * We have examined the actual and potential impact of lipid-lowering treatment. AIMS: To evaluate the impact of lipid-lowering treatment on cholesterol concentrations in the setting of normal care. METHODS: This was a retrospective review of all cholesterol measurements made in Tayside, Scotland, between 1993 and 2002, linked to dispensed prescribing data for lipid-lowering drugs. It was conducted in the setting of normal care and included all patients who underwent cholesterol measurement. The main outcome measure was cholesterol concentration. RESULTS: A total of 401,489 cholesterol measurements were made on 128,240 patients over the study period. Measurements were categorized as treated and untreated according to whether patients were exposed to lipid-lowering treatment at the time the total cholesterol concentration was measured. Those categorized as untreated fell by 0.86 mmol l(-1) (13.9%) and those categorized as treated by 1.45 mmol l(-1) (23.5%). The difference between baseline and follow-up cholesterol concentrations in intention-to-treat patients was 1.53 mmol l(-1) (24%) in 2002. In the same year, mean cholesterol concentration was 4.71 mmol l(-1) (a fall of 1.65 mmol l(-1) or 25.9%) in patients judged to be taking their lipid-lowering medication, compared with 5.20 mmol l(-1) (a fall of 1.16 mmol l(-1) or 18.2%) in those judged not to be taking treatment. Cholesterol fell by 0.38 mmol l(-1) (6.3%) in a cohort of never treated patients (n = 33,679) between 1993 and 2002. CONCLUSIONS: The impact of lipid-lowering drugs on population cholesterol concentrations in the setting of normal care was significant and comparable with the cholesterol reductions seen in the setting of major statin trials, despite a significant proportion of the population receiving low dose treatment. In those subjects judged to be taking their medication, the benefits achieved were substantial. The impact of nondrug factors is indicated by the fall in population cholesterol seen in the absence of lipid-lowering treatment

Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients

Background: 8000 cases of renal cancer are diagnosed each year in the UK, with a five-year survival rate of 50 %. Treatment options are limited; a potential therapeutic target is the Src family kinases (SFKs). SFKs have roles in multiple oncogenic processes and promote metastases in solid tumours. The aim of this study was to investigate SFKs as potential therapeutic targets for clear cell renal cell carcinoma (ccRCC). Methods: SFKs expression was assessed in a tissue microarray consisting of 192 ccRCC patients with full clinical follow-up. SFK inhibitors, dasatinib and saracatinib, were assessed in early ccRCC cell lines, 786-O and 769-P and a metastatic ccRCC cell line, ACHN (± Src) for effects on protein expression, apoptosis, proliferation and wound healing. Results: High nuclear expression of Lyn and the downstream marker of activation, paxillin, were associated with decreased patient survival. Conversely, high cytoplasmic expression of other SFK members and downstream marker of activation, focal adhesion kinase (FAK) were associated with increased patient survival. Treatment of non-metastatic 786-O and 769-P cells with dasatinib, dose dependently reduced SFK activation, shown via SFK (Y419) and FAK (Y861) phosphorylation, with no effect in metastatic ACHN cells. Dasatinib also increased apoptosis, while decreasing proliferation and migration in 786-O and 769-P cell lines, both in the presence and absence of Src protein. Conclusions: Our data suggests that nuclear Lyn is a potential therapeutic target for ccRCC and dasatinib affects cellular functions associated with cancer progression via a Src kinase independent mechanism

Post-polymerization functionalization of poly(ethylene oxide)–poly(β-6-heptenolactone) diblock copolymers to tune properties and self-assembly

Copolymers were synthesized and functionalized with a variety of moieties to tune self-assembly and install drugs or fluorescent dyes. , Polyester-based amphiphilic block copolymers and their nanoassemblies are of significant interest for a wide range of applications due to the degradability of the polyester block. However, the commonly used polyesters lack functional groups on their backbones, limiting the possibilities to chemically modify these polymers. Described here are new poly(ethylene oxide) (PEO)–poly(β-6-heptenolactone) (PHEL) block copolymers having pendant alkenes at each repeat unit on the PHEL block. First, the self-assembly of these block copolymers in aqueous solution was studied and it was found that they formed solid nanoparticles and vesicles depending on the relative block lengths. Next the alkene moieties of the block copolymer were modified with either hydrophilic or hydrophobic pendant groups using thiol–ene reactions, allowing the hydrophilic mass fractions and consequently the self-assembled morphologies to be tuned, accessing both smaller nanoparticles and cylindrical assemblies. It was also demonstrated that the anti-cancer drug paclitaxel or a fluorescent rhodamine dye could be easily conjugated to the block copolymers and the self-assembly of these conjugates was explored. Overall, the results of this study demonstrate that PEO-PHEL block copolymers can serve as versatile backbones for the preparation of functional, polyester-based materials