Tidal influence on self-potential measurements

DJM was supported by NERC CASE studentship NE/I018417/1. The authors would also like to thank Southern Water for access to the borehole at Saltdean. Atkins Global and Southern Water are thanked for funding installation of the equipment and for additional funding under the NERC studentship. The laboratory components of this work were carried out in the TOTAL Reservoir Physics Laboratory at Imperial College London and their support is gratefully acknowledged. Jackson acknowledges partial support from TOTAL under the TOTAL Chairs programme. The data supporting the conclusions of this work are available through the corresponding author.Peer reviewedPublisher PD

Clinical Applications of Remote Ischemic Preconditioning

Ischemia-reperfusion injury is a composite of damage accumulated during reduced perfusion of an organ or tissue and the additional insult sustained during reperfusion. Such injury occurs in a wide variety of clinically important syndromes, such as ischemic heart disease and stroke, which are responsible for a high degree of morbidity and mortality worldwide. Basic research has identified a number of interventions that stimulate innate resistance of tissues to ischemia-reperfusion injury. Here, we summarise the experimental and clinical trial data underpinning one of these “conditioning” strategies, the phenomenon of remote ischemic preconditioning

Characterizing the Self‐Potential Response to Concentration Gradients in Heterogeneous Subsurface Environments

DJM was supported by NERC CASE studentship NE/I018417/1. Additional support was provided by NERC to MG under the Science and Solutions for a Changing Planet Doctoral Training Partnership, run by the Grantham Institute for Climate Change at Imperial College London. Two anonymous reviewers are thanked for their comments, which greatly helped to improve the manuscript. The authors would also like to thank Southern Water for access to the borehole at Saltdean. Atkins Global and Southern Water are thanked for some additional funding under the NERC CASE studentship. The laboratory components of this work were carried out with support from TOTAL who we gratefully acknowledged. All data supporting the conclusions of this work are available in the supporting information.Peer reviewedPublisher PD

Physical factors contributing to rural water supply functionality performance in Uganda

This report communicates the findings generated from one of the project surveys – deconstruction and forensic analysis of 50 individual water points in Uganda. The report presents the new data generated to Uganda’s groundwater resource potential; the nature and condition of hand-pump borehole installations; and the significance of both of these factors to service performance. Based on the evidence collected, the main physical factors affecting functionality performance within Uganda are the poor condition of handpump components, and the complex aquifer resource. The impact of these factors can be mitigated through appropriate material choice for handpump components (non GI), increased investment in borehole siting and testing, and adequate accessibility to repairs and maintenance capacity with breakdowns. These factors should not be considered to be the only driving forces of functionality outcomes in these regions of Uganda, however, and the results of this survey need to be examined alongside the wider project findings. Wider institutional arrangements, resources and dynamics, are likely to play a significant role in the implementation of appropriate borehole construction, siting and design; procurement processes; and the management capacity available for water points at national to local levels

Endothelial C-type natriuretic peptide maintains vascular homeostasis

PMCID: PMC4151218Wellcome Trust (084449/Z/07/Z and 078496/Z/05/Z

The CRESST Dark Matter Search

The current status of CRESST (Cryogenic Rare Event Search using Superconducting Thermometers) and new results concerning the detector development are presented. The basic technique of CRESST is to search for particle Dark Matter (WIMPS, Weakly Interacting Massive particles) by the measurement of non-thermal phonons as created by WIMP-induced nuclear recoils. Combined with the newly developed method of simultaneous measurement of scintillation light, strong background discrimination is possible, resulting in a substantial increase in WIMP detection sensitivity. The short and long term perspectives of CRESST are discussed.Comment: 12 pages, 6 figure

Permeability of the crystalline basement in Uganda : evidence from 665 pumping tests and implications for solar pumping

Crystalline basement rocks of Precambrian age underlie nearly three quarters of Uganda, providing groundwater supplies to meet ever increasing demand from rural areas and urban growth centres. Development of groundwater sources is commonly based on several factors including physical and socio-economic considerations that have a bearing on their functionality and long term reliability. Here we present new transmissivity data from 665 boreholes across basement aquifers in Uganda calculated from previously unanalyzed pumping test data. Other data are available to help interpret the transmissvity values, including borehole lithological logs, weathering thickness, well design and depth to groundwater. Spatial and depth comparisons are made to relate aquifer permeability to lithology and weathering, and also to relate borehole yields to well design. The data provide an improved understanding of the physical permeability of weathered crystalline basement rock aquifers across Uganda, complimenting earlier studies of vertical permeability profiles in focused areas. The analysis helps inform the physical capacity of the aquifer to supply the borehole yields to meet increasing demands, and application the potential for higher abstraction technologies, such as solar pumps