Pedestrian Travel-Time Maps for Homer, Alaska: An anisotropic model to support tsunami evacuation planning

Tsunami-induced pedestrian evacuation for the community of Homer is evaluated using an anisotropic modeling approach developed by the U.S. Geological Survey. The method is based on path-distance algorithms and accounts for variations in land cover and directionality in the slope of terrain. We model evacuation of pedestrians to the tsunami hazard zone boundary and to predetermined assembly areas. The pedestrian travel-time maps are computed for two cases: for travel across all variable terrain or by roads only. Results presented here are intended to provide guidance to local emergency management agencies in tsunami inundation assessment, evacuation planning, and public education to mitigate future tsunami hazards. This report was funded by the National Tsunami Hazard Mitigation Program grant to the Alaska Division of Homeland Security and Emergency Management and University of Alaska Fairbanks from the Department of Commerce/National Oceanic at Atmospheric Administration (NOAA). This does not constitute an endorsement by Alaska Earthquake Center (AEC) or NOAA

Pedestrian Travel-Time Maps for Unalaska/Dutch Harbor, Alaska: An anisotropic model to support tsunami evacuation planning

Tsunami-induced pedestrian evacuation for the community of Unalaska/Dutch Harbor is evaluated using an anisotropic modeling approach developed by the U.S. Geological Survey. The method is based on pathdistance algorithms and accounts for variations in land cover and directionality in the slope of terrain. We model evacuation of pedestrians to the tsunami hazard zone boundary and to predetermined assembly areas. Pedestrian travel-time maps are computed for two cases: for travel across all viable terrain or by roads only. Results presented here are intended to provide guidance to local emergency management agencies for tsunami inundation assessment, evacuation planning, and public education to mitigate future tsunami hazards. This report was funded by the National Tsunami Hazard Mitigation Program grant to the Alaska Division of Homeland Security and Emergency Management and University of Alaska Fairbanks from the Department of Commerce/National Oceanic at Atmospheric Administration (NOAA). This does not constitute an endorsement by Alaska Earthquake Center (AEC) or NOAA

Pedestrian Travel-Time Maps for King Cove, Alaska: An anisotropic model to support tsunami evacuation planning

Tsunami-induced pedestrian evacuation for the community of King Cove is evaluated using an anisotropic modeling approach developed by the U.S. Geological Survey. The applied method is based on path-distance algorithms and accounts for variations in land cover and directionality in the slope of terrain. We model evacuation of pedestrians to the tsunami hazard zone boundary and to predetermined assembly areas. The pedestrian travel-time maps are computed for two cases: for travel across all viable terrain or by roads only. Results presented here are intended to provide guidance to local emergency management agencies for tsunami inundation assessment, evacuation planning, and public education to mitigate future tsunami hazards. This report was funded by the National Tsunami Hazard Mitigation Program grant to the Alaska Division of Homeland Security and Emergency Management and University of Alaska Fairbanks from the Department of Commerce/National Oceanic at Atmospheric Administration (NOAA). This does not constitute an endorsement by Alaska Earthquake Center (AEC) or NOAA

Management of lower limb ischaemia associated with the use of intra-aortic balloon pumps during cardiac surgery

Objective:To audit the lower limb vascular complications associated with the use of an intraaortic balloon pump (IABP) on a cardiothoracic unit over a 12 month period.Design:Retrospective analysis.Setting:Regional university cardiothoracic unit.Patients:Fifty four IABPs inserted into 51 patients.Results:Seventeen patients (33%) died from cardiogenic shock in the immediate postoperative period. Of the remaining 34 patients (37 IABPs), lower limb vascular complications occurred in nine patients (26%) who underwent 11 IABP insertions (30%). Vascular complications included groin haematomas (n = 2 insertions), compartment syndrome (n = 2 insertions), femoral artery trauma (n = 7 insertions).Conclusions:Prompt management by peripheral vascular surgeons resulted in limb salvage in 10 legs and only one death from a pulmonary embolus

Stability conditions and Stokes factors

Let A be the category of modules over a complex, finite-dimensional algebra. We show that the space of stability conditions on A parametrises an isomonodromic family of irregular connections on P^1 with values in the Hall algebra of A. The residues of these connections are given by the holomorphic generating function for counting invariants in A constructed by D. Joyce.Comment: Very minor changes. Final version. To appear in Inventione

Reduced gonadotrophin receptor expression is associated with a more aggressive ovarian cancer phenotype

Follicle-stimulating hormone (FSH) and luteinising hormone (LH) play important roles in regulating cell growth and proliferation in the ovary. However, few studies have explored the expression of FSH and LH receptors (FSHR and LHCGR) in ovarian cancer, and their functional roles in cancer progression remain inconclusive. This study investigated the potential impact of both mRNA (FSHR, LHCGR) and protein (FSHR, LHCGR) expression on ovarian cancer progression using publicly available online databases, qRT-PCR (high grade serous ovarian cancers, HGSOC, n = 29 and benign ovarian tumors, n = 17) and immunohistochemistry (HGSOC, n = 144). In addition, we investigated the effect of FSHR and LHCGR siRNA knockdown on the pro-metastatic behavior of serous ovarian cancer cells in vitro. High FSHR or high LHCGR expression in patients with all subtypes of high-grade ovarian cancer was significantly associated with longer progression-free survival (PFS) and overall survival (OS). High FSHR protein expression was associated with increased PFS (p = 0.050) and OS (p = 0.025). HGSOC patients with both high FSHR and high LHCGR protein levels had the best survival outcome, whilst both low FSHR and low LHCGR expression was associated with poorest survival (p = 0.019). Knockdown of FSHR significantly increased the invasion of serous ovarian cancer cells (OVCAR3 and COV362) in vitro. LHCGR knockdown also promoted invasion of COV362 cells. This study highlights that lower FSHR and LHCGR expression is associated with a more aggressive epithelial ovarian cancer phenotype and promotes pro-metastatic behaviour.Janelle Cheung, Noor A. Lokman, Riya D. Abraham, Anne M. Macpherson, Eunice Lee , Frank Grutzner, Nicolae Ghinea, Martin K. Oehler and Carmela Ricciardell

Democracy and governance networks: compatible or not?

The relationship between representative democracy and governance networks is investigated at a theoretical level. Four conjectures about the relationship are defined. The incompatibility conjectures rests on the primacy of politics and sees governance networks as a threat. The complementarity conjecture presents governance networks as a means of enabling greater participation in the policy process and sensitivity in programme implementation. The transitional conjecture posits a wider evolution of governance forms towards network relationships. The instrumental conjecture views governance networks as a powerful means through which dominant interests can achieve their goals. Illustrative implications for theory and practice are identified, in relation to power in the policy process, the public interest, and the role of public managers. The heuristic potential of the conjectures is demonstrated through the identification of an outline research agenda

Search for R-Parity Violating Decays of Scalar Fermions at LEP

A search for pair-produced scalar fermions under the assumption that R-parity is not conserved has been performed using data collected with the OPAL detector at LEP. The data samples analysed correspond to an integrated luminosity of about 610 pb-1 collected at centre-of-mass energies of sqrt(s) 189-209 GeV. An important consequence of R-parity violation is that the lightest supersymmetric particle is expected to be unstable. Searches of R-parity violating decays of charged sleptons, sneutrinos and squarks have been performed under the assumptions that the lightest supersymmetric particle decays promptly and that only one of the R-parity violating couplings is dominant for each of the decay modes considered. Such processes would yield final states consisting of leptons, jets, or both with or without missing energy. No significant single-like excess of events has been observed with respect to the Standard Model expectations. Limits on the production cross- section of scalar fermions in R-parity violating scenarios are obtained. Constraints on the supersymmetric particle masses are also presented in an R-parity violating framework analogous to the Constrained Minimal Supersymmetric Standard Model.Comment: 51 pages, 24 figures, Submitted to Eur. Phys. J.

Measurement of the Hadronic Photon Structure Function F_2^gamma at LEP2

The hadronic structure function of the photon F_2^gamma is measured as a function of Bjorken x and of the factorisation scale Q^2 using data taken by the OPAL detector at LEP. Previous OPAL measurements of the x dependence of F_2^gamma are extended to an average Q^2 of 767 GeV^2. The Q^2 evolution of F_2^gamma is studied for average Q^2 between 11.9 and 1051 GeV^2. As predicted by QCD, the data show positive scaling violations in F_2^gamma. Several parameterisations of F_2^gamma are in agreement with the measurements whereas the quark-parton model prediction fails to describe the data.Comment: 4 pages, 2 figures, to appear in the proceedings of Photon 2001, Ascona, Switzerlan