Geomagnetically induced current model validation from New Zealand's South Island

Geomagnetically induced currents (GICs) during a space weather event have previously caused transformer damage in New Zealand. During the 2015 St. Patrick's Day Storm, Transpower NZ Ltd has reliable GIC measurements at 23 different transformers across New Zealand's South Island. These observed GICs show large variability, spatially and within a substation. We compare these GICs with those calculated from a modeled geolectric field using a network model of the transmission network with industry‐provided line, earthing, and transformer resistances. We calculate the modeled geoelectric field from the spectra of magnetic field variations interpolated from measurements during this storm and ground conductance using a thin‐sheet model. Modeled and observed GIC spectra are similar, and coherence exceeds the 95% confidence threshold, for most valid frequencies at 18 of the 23 transformers. Sensitivity analysis shows that modeled GICs are most sensitive to variation in magnetic field input, followed by the variation in land conductivity. The assumption that transmission lines follow straight lines or getting the network resistances exactly right is less significant. Comparing modeled and measured GIC time series highlights that this modeling approach is useful for reconstructing the timing, duration, and relative magnitude of GIC peaks during sudden commencement and substorms. However, the model significantly underestimates the magnitude of these peaks, even for a transformer with good spectral match. This is because of the limited range of frequencies for which the thin‐sheet model is valid and severely limits the usefulness of this modeling approach for accurate prediction of peak GICs

Symptomatic retrochiasmal lesions in multiple sclerosis: Clinical features, visual evoked potentials, and magnetic resonance imaging

We have studied 18 patients with relapsing-remitting multiple sclerosis (MS) who had symptomatic visual field defects due to retrochiasmal lesions. In 17, the lesion responsible was identified by magnetic resonance imaging (MRI), computed x-ray tomography (CT), or both. The lesion responsible involved the posterior optic radiations in eight cases, the optic tract and lateral geniculate nucleus in six, and the posterior limb of the internal capsule in three. The prognosis for recovery of the field defect was good; complete recovery occurred in 14 patients, and only two showed no recovery at all. The striking characteristic of the lesions was that most were unusually large; indeed, many were detectable on CT as well as MRI. Half-field asymmetries of either amplitude or latency of the visual evoked potentials (VEPs), consistent with a postchiasmal lesion, were present in only five out of 13 patients acutely. In only three of these did the abnormality persist at follow-up. We conclude that only large postchiasmal lesions are likely to cause symptomatic homonymous field defects in MS, usually characterized by rapid recovery. Hemifield VEPs have a low sensitivity for the detection of postchiasmal as compared with prechiasmal abnormalities

Quantitative magnetic resonance imaging in multiple sclerosis: the effect of high dose intravenous methylprednisolone.

Magnetic resonance imaging was performed on 50 patients with clinically definite or probable multiple sclerosis before and 15 days after starting treatment with intravenous methylprednisolone (0.5 g daily for 5 days). Scans were abnormal in 49 patients. New lesions had appeared on the second scan in nine individuals and in seven a single pre-existing lesion appeared to have become smaller but in no case were lesions seen to disappear. Two patients showed both reduction in the size of an abnormal area and development of a single new lesion indicating that corticosteroids do not appear rapidly to alter the process underlying plaque formation. Measurements of relaxation times were performed in 12 randomly selected patients. All showed elevated values in normal appearing white matter but not cortex before treatment compared with 18 healthy controls. After treatment a significant decrease of T1 and T2 was observed in cortex, and of T1 alone in normal appearing white matter. No significant change could be detected within lesions, a finding attributed to the wide range of relaxation values observed at these sites before treatment. Since brain water content is increased in normal appearing white matter of multiple sclerosis patients, and is significantly reduced by high-dose methylprednisolone, resolution of oedema may contribute to the rapid spontaneous or corticosteroid induced symptomatic recovery that characterises the disease in its early stages

Advances in imaging to support the development of novel therapies for multiple sclerosis.

Multiple sclerosis (MS) is a common neurological disease in North America and Europe. Although most patients develop major locomotor disability over the course of 15-20 years, in approximately one-third of patients the long-term course is favorable, with minimal disability. Although current disease-modifying treatments reduce the relapse rate, their long-term effects are uncertain. MS treatment trials are challenging because of the variable clinical course and typically slow evolution of the disease. Magnetic resonance imaging (MRI) is sensitive in monitoring MS pathology and facilitates evaluation of potential new treatments. MRI measurements of lesion activity have identified new immunomodulatory treatments for preventing relapse. Quantitative measurements of tissue volume and structural integrity, capable of detecting neuroprotection and repair, should facilitate new treatments designed to prevent irreversible disability. Higher-field MR scanners and new positron emission tomography (PET) radioligands are providing new insights into cellular and pathophysiological abnormalities, and should be valuable in future therapeutic trials. Retinal axonal loss measured using optical coherence tomography (OCT) can assess acute neuroprotection in optic neuritis