232 research outputs found
Junior Recital: Kevin Maclean, Tenor
Kemp Recital Hall Saturday Afternoon April 27, 1996 4:30p.m
Political ideology and the discursive construction of the multinational hotel industry
How might political ideology help to shape an organizational field? We explore the discursive construction of the multinational hotel industry through analysis of one of its leading actors, Hilton International (HI), conceived by Conrad Hilton as a means of combatting communism by facilitating world peace through international trade and travel. While the politicized rhetoric employed at hotel openings reflected institutional diversity, it resonated in parallel with a strong anti-communist discourse. We show that through astute political sensemaking and sensegiving, macro-political discourse that is ideological and universalizing may be allied to micro-political practices in strategic action fields. Our study illuminates the processes of early-stage post-war globalization and its accompanying discourses, demonstrating that the foundation of a global industry may be ideologically inspired. Our primary contribution to theory is specific acknowledgement of the importance of political ideology as a particular ‘social skill’, helping to determine how international business has been ‘won’.</jats:p
Quantum optical signal processing in diamond
Controlling the properties of single photons is essential for a wide array of
emerging optical quantum technologies spanning quantum sensing, quantum
computing, and quantum communications. Essential components for these
technologies include single photon sources, quantum memories, waveguides, and
detectors. The ideal spectral operating parameters (wavelength and bandwidth)
of these components are rarely similar; thus, frequency conversion and spectral
control are key enabling steps for component hybridization. Here we perform
signal processing of single photons by coherently manipulating their spectra
via a modified quantum memory. We store 723.5 nm photons, with 4.1 nm
bandwidth, in a room-temperature diamond crystal; upon retrieval we demonstrate
centre frequency tunability over 4.2 times the input bandwidth, and bandwidth
modulation between 0.5 to 1.9 times the input bandwidth. Our results
demonstrate the potential for diamond, and Raman memories in general, to be an
integrated platform for photon storage and spectral conversion.Comment: 6 pages, 4 figure
Storage and retrieval of ultrafast single photons using a room-temperature diamond quantum memory
We report the storage and retrieval of single photons, via a quantum memory,
in the optical phonons of room-temperature bulk diamond. The THz-bandwidth
heralded photons are generated by spontaneous parametric downconversion and
mapped to phonons via a Raman transition, stored for a variable delay, and
released on demand. The second-order correlation of the memory output is
, demonstrating preservation of non-classical
photon statistics throughout storage and retrieval. The memory is low-noise,
high-speed and broadly tunable; it therefore promises to be a versatile
light-matter interface for local quantum processing applications.Comment: 6 pages, 4 figure
Storage of polarization-entangled THz-bandwidth photons in a diamond quantum memory
Bulk diamond phonons have been shown to be a versatile platform for the
generation, storage, and manipulation of high-bandwidth quantum states of
light. Here we demonstrate a diamond quantum memory that stores, and releases
on demand, an arbitrarily polarized 250 fs duration photonic qubit. The
single-mode nature of the memory is overcome by mapping the two degrees of
polarization of the qubit, via Raman transitions, onto two spatially distinct
optical phonon modes located in the same diamond crystal. The two modes are
coherently recombined upon retrieval and quantum process tomography confirms
that the memory faithfully reproduces the input state with average fidelity
with a total memory efficiency of . In an
additional demonstration, one photon of a polarization-entangled pair is stored
in the memory. We report that entanglement persists in the retrieved state for
up to 1.3 ps of storage time. These results demonstrate that the diamond phonon
platform can be used in concert with polarization qubits, a key requirement for
polarization-encoded photonic processing
The Impact of Increased Cost-Sharing on Utilization of Low Value Services: Evidence from the State of Oregon
In this study we examine the impact of a value-based insurance design (V-BID) program implemented between 2010 and 2013 at a large public employer in the state of Oregon. The program substantially increased cost-sharing, specifically copayments and coinsurance, for several healthcare services believed to be of low value and overused (sleep studies, endoscopies, advanced imaging, and surgeries). Using a differences-in-differences design coupled with granular, administrative health insurance claims data, we estimate the change in low value healthcare service utilization among beneficiaries before and after program implementation relative to a comparison group of beneficiaries who were not exposed to the V-BID. Our findings suggest that the V-BID significantly reduced utilization of targeted services. These findings have important implications for both public and private healthcare policies as V-BID principles are rapidly proliferating in healthcare markets
The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1 pulmonary circulation
Pulmonary arterial hypertension (PAH) is a devastating vasculopathy that predominates in women and has been associated with
dysregulated estrogen and serotonin signaling. Overexpression of the serotonin transporter (SERT+) in mice results in an estrogen-dependent
development of pulmonary hypertension (PH). Estrogen metabolism by cytochrome P450 1B1 (CYP1B1) contributes to the pathogenesis of
PAH, and serotonin can increase CYP1B1 expression in human pulmonary arterial smooth muscle cells (hPASMCs). We hypothesized that
an increase in intracellular serotonin via increased SERT expression may dysregulate estrogen metabolism via CYP1B1 to facilitate PAH.
Consistent with this hypothesis, we found elevated lung CYP1B1 protein expression in female SERT+ mice accompanied by PH, which was
attenuated by the CYP1B1 inhibitor 2,3',4,5'-tetramethoxystilbene (TMS). Lungs from female SERT+ mice demonstrated an increase in oxidative
stress that was marked by the expression of 8-hydroxyguanosine; however, this was unaffected by CYP1B1 inhibition. SERT expression
was increased in monocrotaline-induced PH in female rats; however, TMS did not reverse PH in monocrotaline-treated rats but prolonged
survival. Stimulation of hPASMCs with the CYP1B1 metabolite 16α-hydroxyestrone increased cellular proliferation, which was attenuated by
an inhibitor (MPP) of estrogen receptor alpha (ERα) and a specific ERα antibody. Thus, increased intracellular serotonin caused by increased
SERT expression may contribute to PAH pathobiology by dysregulation of estrogen metabolic pathways via increased CYP1B1 activity. This
promotes PASMC proliferation by the formation of pathogenic metabolites of estrogen that mediate their effects via ERα. Our studies indicate
that targeting this pathway in PAH may provide a promising antiproliferative therapeutic strategy
- …