Migrant Common Eider, Somateria mollissima, Collisions with Power Transmission Lines and Shortwave Communication Towers on the Tantramar Marsh in Southeastern New Brunswick

Between 1971 and 2009, 85 dead, injured, or grounded Common Eiders, Somateria mollissima, were recorded on the Tantramar Marsh in southeastern New Brunswick, apparently the result of collisions with power transmission lines and shortwave communication towers. Of 82 location observations, 53 (65%) were near a series of power transmission lines and 21 (26%) were in the vicinity of shortwave communication towers. Of the 85 birds observed, 43 (51%) were found dead, 18 (21%) were found alive on the ground with undetermined injuries, 5 (6%) were found alive with broken wings, and 9 birds (11%) were found alive with no obvious external injuries and were released in water. A further 10 live birds (12%) were observed on small bodies of water and appeared unable to fly. Occurrences appear to be predominantly during fall migration, with most sightings recorded between 9 October and 21 December (99%, n = 73). The effects of cumulative mortality on Common Eiders should be considered if further infrastructure within the Tantramar Marsh or infrastructure involving other known overland routes used by Common Eiders during migration is proposed

Details of Eastern Coyote, Canis latrans, Predation on Great Black-backed Gull, Larus marinus, Eggs on Boot Island National Wildlife Area, Nova Scotia

We detail field observations of Eastern Coyote eating Great Black-backed Gull eggs for the first time in the literature. Photographic evidence of the remaining egg shells allowed us to identify the Coyote as the predator

Cliff Roosting by Migrant Semipalmated Sandpipers, Calidris pusilla, at Farrier's Cove, Shepody Bay, New Brunswick

An observation of Semipalmated Sandpipers roosting on a cliff face in Shepody Bay, New Brunswick, suggests changes from “traditional” roosting sites. Sandpipers may be altering their roosting patterns due to pressures from avian predators such as the recent, and successful, re-introduction of the Peregrine Falcon

Details of Eastern Coyote, Canis latrans, Predation on Great Black-backed Gull, Larus marinus, Eggs on Boot Island National Wildlife Area, Nova Scotia

We detail field observations of Eastern Coyote eating Great Black-backed Gull eggs for the first time in the literature. Photographic evidence of the remaining egg shells allowed us to identify the Coyote as the predator

Resolving the paradox of shame: differentiating among specific appraisal-feeling combinations explains pro-social and self-defensive motivation

Research has shown that people can respond both self-defensively and pro-socially when they experience shame. We address this paradox by differentiating among specific appraisals (of specific self-defect and concern for condemnation) and feelings (of shame, inferiority, and rejection) often reported as part of shame. In two Experiments (Study 1: N = 85; Study 2: N = 112), manipulations that put participants’ social-image at risk increased their appraisal of concern for condemnation. In Study 2, a manipulation of moral failure increased participants’ appraisal that they suffered a specific self-defect. In both studies, mediation analyses showed that effects of the social-image at risk manipulation on self-defensive motivation were explained by appraisal of concern for condemnation and felt rejection. In contrast, the effect of the moral failure manipulation on pro-social motivation in Study 2 was explained by appraisal of a specific self-defect and felt shame. Thus, distinguishing among the appraisals and feelings tied to shame enabled clearer prediction of pro-social and self-defensive responses to moral failure with and without risk to social-image

Lack of Association of Interferon Regulatory Factor 1 with Severe Malaria in Affected Child-Parental Trio Studies across Three African Populations

Interferon Regulatory Factor 1 (IRF-1) is a member of the IRF family of transcription factors, which have key and diverse roles in the gene-regulatory networks of the immune system. IRF-1 has been described as a critical mediator of IFN-gamma signalling and as the major player in driving TH1 type responses. It is therefore likely to be crucial in both innate and adaptive responses against intracellular pathogens such as Plasmodium falciparum. Polymorphisms at the human IRF1 locus have been previously found to be associated with the ability to control P. falciparum infection in populations naturally exposed to malaria. In order to test whether genetic variation at the IRF1 locus also affects the risk of developing severe malaria, we performed a family-based test of association for 18 Single Nucleotide Polymorphisms (SNPs) across the gene in three African populations, using genotype data from 961 trios consisting of one affected child and his/her two parents (555 from The Gambia, 204 from Kenya and 202 from Malawi). No significant association with severe malaria or severe malaria subphenotypes (cerebral malaria and severe malaria anaemia) was observed for any of the SNPs/haplotypes tested in any of the study populations. Our results offer no evidence that the molecular pathways regulated by the transcription factor IRF-1 are involved in the immune-based pathogenesis of severe malaria

Bringing the Tiger Back from the Brink—The Six Percent Solution

This article does not have an abstract

The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility

Pathological classifications in current use for the assessment of glomerular disease have been typically opinion-based and built on the expert assumptions of renal pathologists about lesions historically thought to be relevant to prognosis. Here we develop a unique approach for the pathological classification of a glomerular disease, IgA nephropathy, in which renal pathologists first undertook extensive iterative work to define pathologic variables with acceptable inter-observer reproducibility. Where groups of such features closely correlated, variables were further selected on the basis of least susceptibility to sampling error and ease of scoring in routine practice. This process identified six pathologic variables that could then be used to interrogate prognostic significance independent of the clinical data in IgA nephropathy (described in the accompanying article). These variables were (1) mesangial cellularity score; percentage of glomeruli showing (2) segmental sclerosis, (3) endocapillary hypercellularity, or (4) cellular/ fibrocellular crescents; (5) percentage of interstitial fibrosis/ tubular atrophy; and finally (6) arteriosclerosis score. Results for interobserver reproducibility of individual pathological features are likely applicable to other glomerulonephritides, but it is not known if the correlations between variables depend on the specific type of glomerular pathobiology. Variables identified in this study withstood rigorous pathology review and statistical testing and we recommend that they become a necessary part of pathology reports for IgA nephropathy. Our methodology, translating a strong evidence-based dataset into a working format, is a model for developing classifications of other types of renal disease